Zobrazeno 1 - 10
of 36
pro vyhledávání: '"and Masako Kuno"'
Autor:
Zenichi Ikeda, Taku Kamei, Yusuke Sasaki, Matthew Reynolds, Nozomu Sakai, Masato Yoshikawa, Michiko Tawada, Nao Morishita, Douglas R. Dougan, Chien-Hung Chen, Irena Levin, Hua Zou, Masako Kuno, Naoto Arimura, Yusuke Kikukawa, Mitsuyo Kondo, Kimio Tohyama, Kenjiro Sato
Publikováno v:
Journal of Medicinal Chemistry. 66:6354-6371
Autor:
Misato Ito, Shunji Yamazaki, Kaoru Yamagami, Masako Kuno, Yoshiaki Morita, Kenji Okuma, Koji Nakamura, Noboru Chida, Masamichi Inami, Takayuki Inoue, Shohei Shirakami, Yasuyuki Higashi
Publikováno v:
Journal of Pharmacological Sciences, Vol 133, Iss 1, Pp 25-33 (2017)
The Janus kinase (JAK) family of tyrosine kinases is associated with various cytokine receptors. JAK1 and JAK3 play particularly important roles in the immune response, and their inhibition is expected to provide targeted immune modulation. Several o
Externí odkaz:
https://doaj.org/article/f4e9fbfdb61f4dfcbfd9963e6911a4cf
Autor:
Masako Kuno, Yuya Nishiyama, Akio Imanishi, Hiroshi Nagata, Takuya Kato, Izumi Kamo, Satoshi Okanishi, Kyoko Yoshikawa, Gale O'Connell
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 378:60-68
Under healthy condition, more than one urethra-closing reflex, including both bladder afferent-independent and -dependent actions function during momentary elevation of intravesical (bladder) pressure to prevent urinary incontinence. In the current s
Autor:
Akira Shibata, Masako Kuno, Ryutaro Adachi, Yosuke Sato, Harumi Hattori, Atsushi Matsuda, Yuumi Okuzono, Keiko Igaki, Yusuke Tominari, Terufumi Takagi, Masato Yabuki, Masanori Okaniwa
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0186587 (2017)
Scleroderma has clinical characteristics including skin and other tissue fibrosis, but there is an unmet need for anti-fibrotic therapy. Halofuginone (HF) is a well-known anti-fibrosis agent in preclinical and clinical studies which exerts its effect
Externí odkaz:
https://doaj.org/article/26bb6e9330de404c81a6ad28a8612483
Autor:
Shohei Shirakami, Kenji Okuma, Yoshiaki Morita, Takayuki Inoue, Misato Ito, Masako Kuno, Shunji Yamazaki, Masamichi Inami, Yasuyuki Higashi, Kaoru Yamagami, Noboru Chida, Koji Nakamura
Publikováno v:
Journal of Pharmacological Sciences, Vol 133, Iss 1, Pp 25-33 (2017)
The Janus kinase (JAK) family of tyrosine kinases is associated with various cytokine receptors. JAK1 and JAK3 play particularly important roles in the immune response, and their inhibition is expected to provide targeted immune modulation. Several o
Autor:
Maiko Takiguchi, Hiroyuki Ueno, Yoshihisa Nakada, Masami Yamada, Tomoya Yukawa, Tetsuya Tsukamoto, Hideyuki Nakagawa, Nobuki Sakauchi, Kamei Taku, Ikuo Fujimori, Tomoko Igari, Masako Kuno, Yasushi Fujioka, Izumi Kamo, Yuji Ishichi, Yusuke Ohba
Publikováno v:
Bioorganic & Medicinal Chemistry. 24:3716-3726
Peripheral-selective inhibition of noradrenaline reuptake is a novel mechanism for the treatment of stress urinary incontinence to overcome adverse effects associated with central action. Here, we describe our medicinal chemistry approach to discover
Autor:
Harumi Hattori, Morihisa Saitoh, Yoshihisa Nakada, Kumar Singh Saikatendu, Yuji Shimizu, Masako Kuno, Hua Zou, Taisuke Katoh, Masato Yoshikawa, Seki Tomohiro, Masanori Nakakariya, Etsuro Watanabe, Takuro Okai, Takayuki Tatamiya, Takatoshi Yogo, Tsuyoshi Ishii, Simone V. Bigi
Publikováno v:
Journal of medicinal chemistry. 61(6)
We report the discovery of 7-oxo-2,4,5,7-tetrahydro-6 H-pyrazolo[3,4- c]pyridine derivatives as a novel class of receptor interacting protein 1 (RIP1) kinase inhibitors. On the basis of the overlay study between HTS hit 10 and GSK2982772 (6) in RIP1
Autor:
Tsuyoshi Ishii, Masako Kuno, Masato Yoshikawa, Manabu Mochizuki, Tomohiro Kawamoto, Takuro Okai, Sachio Shibata, Takatoshi Yogo, Masanori Nakakariya, Misa Iwatani-Yoshihara, Satoko Unno
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Scientific Reports
Scientific Reports
The proof of target engagement (TE) is a key element for evaluating potential investment in drug development. The cellular thermal shift assay (CETSA) is expected to facilitate direct measurement of intracellular TE at all stages of drug development.
Autor:
Tomoya Yukawa, Ikuo Fujimori, Taku Kamei, Yoshihisa Nakada, Nobuki Sakauchi, Masami Yamada, Yusuke Ohba, Hiroyuki Ueno, Maiko Takiguchi, Masako Kuno, Izumi Kamo, Hideyuki Nakagawa, Yasushi Fujioka, Tomoko Igari, Yuji Ishichi, Tetsuya Tsukamoto
Publikováno v:
Bioorganicmedicinal chemistry. 24(14)
Peripherally selective inhibition of noradrenaline reuptake is a novel mechanism for the treatment of stress urinary incontinence to overcome adverse effects associated with central action. Herein, we describe our medicinal chemistry approach to disc
Autor:
Masako Kuno, Huang Shih-Chung, Gil Nam Lee, Syunsuke Yamamoto, Suk Young Cho, Kazuyoshi Aso, Masato Yoshida, Shogo Marui, Norihito Tokunaga, Yusuke Ohba, Takatoshi Yogo, Hideyuki Nakagawa, Satoshi Sasaki, Masaki Seto, Atsutoshi Okabe, Takahiro Miyazaki, Chul Yun Rhim, Yousuke Satou, Robert J. Skene, Cheol Hwan Yoon, Hiroyuki Nagamiya
Publikováno v:
Journal of medicinal chemistry. 59(2)
We report herein the discovery and optimization of 3-amino-1,5-dihydro-4H-pyrazolopyridin-4-one TYK2 inhibitors. High-throughput screening against TYK2 and JAK1-3 provided aminoindazole derivative 1 as a hit compound. Scaffold hopping of the aminoind