Výsledky vyhledávání - "and Mary K. Danks"

Akademický článek

Development of a tumor-selective approach to treat metastatic cancer.

Autor: Karen S Aboody, Rebecca A Bush, Elizabeth Garcia, Marianne Z Metz, Joseph Najbauer, Kristine A Justus, Doris A Phelps, Joanna S Remack, Karina Jin Yoon, Shanna Gillespie, Seung U Kim, Carlotta A Glackin, Philip M Potter, Mary K Danks

Publikováno v: PLoS ONE, Vol 1, p e23 (2006)

Patients diagnosed with metastatic cancer have almost uniformly poor prognoses. The treatments available for patients with disseminated disease are usually not curative and have side effects that limit the therapy that can be given. A treatment that

Externí odkaz: https://doaj.org/article/fbdc182300744ae18ba3c46343dfa818

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Cell adhesion molecules as targets for therapy of neuroblastoma

Autor: Karina J. Yoon, Mary K. Danks

Publikováno v: Cancer Biology & Therapy. 8:306-311

Cell adhesion molecules (CAMs) are glycoproteins expressed on the surface of cell membranes. In normal cells, CAMs participate in a variety of biological processes including cell proliferation, migration and differentiation. In tumor cells, CAMs have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d6fe2215331720a766b0b9b848e72e5
https://doi.org/10.4161/cbt.8.4.7446

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Planarity and Constraint of the Carbonyl Groups in 1,2-Diones Are Determinants for Selective Inhibition of Human Carboxylesterase 1

Autor: Janice L. Hyatt, Lyudmila Tsurkan, Charles R. Ross, Guy Crundwell, R. Kip Guy, Philip M. Potter, M. Jason Hatfield, Randy M. Wadkins, Stephanie A. Cantalupo, Mary K. Danks, Latorya D. Hicks, Carol C. Edwards

Publikováno v: Journal of Medicinal Chemistry. 50:5727-5734

Carboxylesterases (CE) are ubiquitous enzymes responsible for the detoxification of xenobiotics, including numerous clinically used drugs. Therefore, the selective inhibition of these proteins may prove useful in modulating drug half-life and bioavai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c08d60bf36bac6e900c1f9c6557cfee
https://doi.org/10.1021/jm0706867

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Targeting Methylguanine-DNA Methyltransferase in the Treatment of Neuroblastoma

Autor: Lars M. Wagner, Roger E. McLendon, Catherine A. Billups, K. Jin Yoon, Brian Weiss, Mary K. Danks

Publikováno v: Clinical Cancer Research. 13:5418-5425

Purpose: The combination of temozolomide and irinotecan has preclinical schedule-dependent synergy against neuroblastoma but is not curative for relapsed high-risk patients. We hypothesized that the DNA repair protein methylguanine-DNA methyltransfer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54f1bb7000cb625a88f4937b86c239eb
https://doi.org/10.1158/1078-0432.ccr-07-0418

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Intravascular administration of tumor tropic neural progenitor cells permits targeted delivery of interferon-β and restricts tumor growth in a murine model of disseminated neuroblastoma

Autor: Andrew M. Davidoff, Annastasia A. Ouma, Catherine Y.C. Ng, John T. Gray, Paxton V. Dickson, Seung U. Kim, John B. Hamner, Rebecca A. Burger, Mary K. Danks, Karen S. Aboody, Elizabeth Garcia

Publikováno v: Journal of Pediatric Surgery. 42:48-53

Background Interferon- β (IFN- β ) has potent antitumor activity; however, systemic toxicity has limited its clinical use. We investigated the potential of targeted delivery using tumor-tropic neural progenitor cells (NPCs) transduced to express hu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d22c97aeb7d792b2b736022b45ea824d
https://doi.org/10.1016/j.jpedsurg.2006.09.050

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Tumor-Targeted Enzyme/Prodrug Therapy Mediates Long-term Disease-Free Survival of Mice Bearing Disseminated Neuroblastoma

Autor: Joseph Najbauer, Monika Wierdl, Seung U. Kim, Mary K. Danks, Marianne Z. Metz, Rebecca A. Bush, Joanna S. Remack, Lyudmila Tsurkan, Karen S. Aboody, K. Jin Yoon, Elizabeth Garcia, Philip M. Potter

Publikováno v: Cancer Research. 67:22-25

Neural stem cells and progenitor cells migrate selectively to tumor loci in vivo. We exploited the tumor-tropic properties of HB1.F3.C1 cells, an immortalized cell line derived from human fetal telencephalon, to deliver the cDNA encoding a secreted f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::737d80e7ac4b175efe95c9a935dc97d2
https://doi.org/10.1158/0008-5472.can-06-3607

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Intracellular inhibition of carboxylesterases by benzil: modulation of CPT-11 cytotoxicity

Autor: Janice L. Hyatt, Carol C. Edwards, Monika Wierdl, Philip M. Potter, Lyudmila Tsurkan, Mary K. Danks

Publikováno v: Molecular Cancer Therapeutics. 5:2281-2288

Carboxylesterases are ubiquitous proteins responsible for the detoxification of xenobiotics. However, these enzymes also activate prodrugs, such as the anticancer agents capecitabine and CPT-11. As a consequence, overexpression of carboxylesterases w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07b59729292d6a7d7ecaf3dbeb297d14
https://doi.org/10.1158/1535-7163.mct-06-0160

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Phase II study of oxaliplatin in children with recurrent or refractory medulloblastoma, supratentorial primitive neuroectodermal tumors, and atypical teratoid rhabdoid tumors

Autor: James M. Boyett, Clinton F. Stewart, Amar Gajjar, Adekunle M. Adesina, Roger E. McLendon, Michael L. Hancock, Maryam Fouladi, Mary K. Danks, Burgess B. Freeman, Tina Young Poussaint, Susan M. Blaney, Christine E. Fuller

Publikováno v: Cancer. 107:2291-2297

BACKGROUND. An open-label Phase II study of oxaliplatin was conducted to evaluate its safety and efficacy in children with recurrent or refractory medulloblastoma (MB), supratentorial primitive neuroectodermal tumors (SPNET), and atypical teratoid rh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::197e5177d5550b9a0cac9cec101d8e2b
https://doi.org/10.1002/cncr.22241

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Inhibition of Carboxylesterases by Benzil (Diphenylethane-1,2-dione) and Heterocyclic Analogues Is Dependent upon the Aromaticity of the Ring and the Flexibility of the Dione Moiety

Autor: Allen D Hunter, Randy M. Wadkins, Vanessa Stacy, Kyoung Jin P. Yoon, Janice L. Hyatt, Mary K. Danks, Monika Wierdl, Guy Crundwell, Carol C. Edwards, Matthias Zeller, Philip M. Potter

Publikováno v: Journal of Medicinal Chemistry. 48:5543-5550

Benzil has been identified as a potent selective inhibitor of carboxylesterases (CEs). Essential components of the molecule required for inhibitory activity include the dione moiety and the benzene rings, and substitution within the rings affords inc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d895f8fc22ffd2c229c5c60c208cfb2e
https://doi.org/10.1021/jm0504196

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Activation and antitumor activity of CPT-11 in plasma esterase-deficient mice

Autor: Janice L. Hyatt, Peter J. Houghton, Clinton F. Stewart, Kody R. Taylor, Pamela J. Cheshire, Lisa C. Iacono, Christopher L. Morton, Mary K. Danks, Philip M. Potter

Publikováno v: Cancer Chemotherapy and Pharmacology. 56:629-636

Purpose: To examine the antitumor activity and the pharmacokinetics of CPT-11 (irinotecan, 7-ethyl-10-[4-(1-piperidino)-1-piperidino] carbonyloxycamptothecin) in a plasma esterase-deficient scid mouse model, bearing human tumor xenografts. Experiment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b22bddf2f64c4b8500069d5ae936928a
https://doi.org/10.1007/s00280-005-1027-y

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