Zobrazeno 1 - 10
of 50
pro vyhledávání: '"and Marvin M. Hansen"'
Autor:
Hao Sun, Michael O. Frederick, Roger Ryan Rothhaar, Amy C. DeBaillie, Brian Morgan Watson, Carlos Mateos, Leonard L. Winneroski, Carlos Jaramillo, Talbi Kaoudi, Matthew Johnson, Pablo Garcia-Losada, Srinivas Gangula, Peter J. Lindsay-Scott, Steven James Green, Dustin J. Mergott, Dajiang Jing, Marvin M. Hansen, José Eugenio de Diego, Juan A. Rincón, Kevin D. Seibert, Lei Zhang, Jiuyuan Li
Publikováno v:
Organic Process Research & Development. 24:306-314
Herein we report a summary of the synthetic development of LY3202626 from the initial discovery route to a final route that was scaled to make 150 kg. Key developments include the use of a [3 + 2] ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd409beaf54c99668ae6510bc63b7fdb
https://doi.org/10.1021/acs.oprd.9b00471
https://doi.org/10.1021/acs.oprd.9b00471
Autor:
Tony Y. Zhang, Hannah Yu, John R. Rizzo, Jeffrey A. Ward, Thomas M. Koenig, Rachel N. Richey, David Mitchell, Marvin M. Hansen, Neil J. Kallman, Ryan J. Linder
Publikováno v:
Organic Process Research & Development. 21:208-217
A practical pilot plant convergent synthesis of MR antagonist LY2623091 was established. For synthesis convergence, a vinyl bromide geometric isomer and chiral alaninol derivative were required building blocks. Key to the synthesis route development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2ee0fb900112e1b3496fccfb18c02c0
https://doi.org/10.1021/acs.oprd.6b00368
https://doi.org/10.1021/acs.oprd.6b00368
Autor:
David L. McKinzie, Bin Liu, Christian C. Felder, G. Stuart Gregory, Marla L. Watt, Robert E. Stratford, Carrie H. Croy, Hoogestraat Paul J, Jennifer R. Allen, James Andrew Jamison, Zhigang Rao, David A. Evans, William W. Turner, Frank P. Bymaster, Stephen Hitchcock, Mark G. Bures, Marvin M. Hansen, Fese M. Okha-Mokube
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:4158-4163
The observation that cholinergic deafferentation of circuits projecting from forebrain basal nuclei to frontal and hippocampal circuits occurs in Alzheimer's disease has led to drug-targeting of muscarinic M1 receptors to alleviate cognitive symptoms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::460bbb7f85712e78446c74ee34c30d7f
https://doi.org/10.1016/j.bmcl.2015.08.011
https://doi.org/10.1016/j.bmcl.2015.08.011
Autor:
Marvin M. Hansen, Jennifer Kuehne-Willmore, Amy C. DeBaillie, Molly Harding, Joseph R. Martinelli, Daniel J. Jarmer, Michael J. McCulley, Dominique Huber, Michael E. Laurila, Thomas J. Martin, David W. Hoard, Theo Zweifel, Ryan J. Linder, Stanley P. Kolis, Nikolay Zaborenko, Enver Arslantas, Rachel N. Richey, Derek R. Starkey, Thomas Kull, Adrienne Hollister, Jeffrey A. Ward, Andrea L. Frederick
Publikováno v:
Organic Process Research & Development. 19:1214-1230
An efficient synthesis of LY2886721 (1) in five steps and 46% overall yield from the chiral nitrone cycloadduct 2 is presented. Minimizing formation of a des-fluoro impurity during hydrogenolysis to cleave the isoxazolidine ring and remove the benzyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1db94ba09df24b6c834b9f697582e3e8
https://doi.org/10.1021/op500327t
https://doi.org/10.1021/op500327t
Autor:
Nikolay Zaborenko, Marvin M. Hansen, Bradley M. Campbell, Ryan J. Linder, Martin D. Johnson, Timothy M. Braden
Publikováno v:
Organic Process Research & Development. 19:1231-1243
The design, development, and implementation of a pilot-scale continuous hydrogenolysis in a catalytic packed bed to generate a starting material is described. Control of a critical defluorination impurity under the reaction conditions has been achiev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18b8acbae940115dbb1ce43fa3cf4315
https://doi.org/10.1021/op5003177
https://doi.org/10.1021/op5003177
Publikováno v:
Organic Process Research & Development. 19:1507-1516
Despite a recent publication describing boronic acids as a “novel class of bacterial mutagen,” process and analytical chemists may not be aware of the potential worker exposure hazards, or of the need to assess boron compounds as potential genoto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb227b72b7d595dc6214784764f82b0d
https://doi.org/10.1021/acs.oprd.5b00150
https://doi.org/10.1021/acs.oprd.5b00150
Autor:
Patrick M. Pollock, Marvin M. Hansen, Michael Miller, Nikolay Zaborenko, Michael R. Heller, Bradley M. Campbell, Joseph L. Phillips, Molly Harding, Christopher L. Burcham, Christopher S. Polster, Kevin P. Cole, Andrea L. Frederick
Publikováno v:
Organic Process Research & Development. 18:1295-1309
The design, development, and implementation of a pilot-scale continuous Schotten–Baumann amide bond formation and reactive crystallization to afford LY2886721 is described. The material met all API quality attributes and was comparable to material
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7efe8757dfcfae7dca64b2c1bd136d48
https://doi.org/10.1021/op500204z
https://doi.org/10.1021/op500204z
Autor:
Eugene F. Kogut, Neil J. Kallman, Dana L. T. Laird, Marvin M. Hansen, J. Craig Ruble, Chin Liu, Lawrence Edward Patterson, Matthew H. Yates, Ryan J. Linder
Publikováno v:
Organic Process Research & Development. 18:501-510
The synthesis of a MET kinase inhibitor in an overall yield of 22% was achieved over eight steps starting with 3-hydroxybenzaldehyde, an improvement from the initial 12-step process with a 5.4% yield. Highlights of the process chemistry design and de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4ae30531806f0a8ac97541e471ca6e4
https://doi.org/10.1021/op400317z
https://doi.org/10.1021/op400317z
Autor:
Michael E. Laurila, Aurpon W. Mitra, Joseph R. Martinelli, Stanley P. Kolis, Marvin M. Hansen
Publikováno v:
Tetrahedron Letters. 54:6580-6583
α-Aminoamides are shown to be useful as ligands in Goldberg amidations. A number of α-aminoamides are examined and the importance of substitution on the α-aminoamides is explored. Acetamide is focused on as the nucleophilic coupling partner due to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::584783b713df41d9a100f9f6e54f443e
https://doi.org/10.1016/j.tetlet.2013.09.099
https://doi.org/10.1016/j.tetlet.2013.09.099
Autor:
Fabrice Lefevre, Beat Wirz, Marvin M. Hansen, Manuela Avi, Van Martin, David Mangan, Antonio Osorio-Lozada, Steven P. Hanlon, Stephan Luetz, John W. Wong, Hans-Peter Meyer, Matthias Kittelmann, Radka Snajdrova, Hans Iding, Thomas Michael Eckrich, Cecilia Branneby, Joseph P. Adams, Kurt Laumen, Thomas S. Moody, Ian Fotheringham, Karen Robins, Karen E. Holt-Tiffin, Andrew J. Collis, Roger M. Howard, Rob ter Halle, Andrew S. Wells, Peter W. Sutton, Daniel Auriol, Gjalt W. Huisman, Ian Archer, Bruno Dumas, Ernst Kupfer, Kurt Kiewel, Matthew D. Truppo
Publikováno v:
Practical Methods for Biocatalysis and Biotransformations 2
Peter W. Sutton, Joseph P. Adams, Ian Archer, Daniel Auriol, Manuela Avi, Cecilia Branneby, Andrew J. Collis, Bruno Dumas, Thomas Eckrich, Ian Fotheringham, Rob ter Halle, Steven Hanlon, Marvin Hansen, K. E. Holt-Tiffin, Roger M. Howard, Gjalt W. Hui
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77fafea9a76d66d13099ed7279022ae8
https://doi.org/10.1002/9781119943426.ch1
https://doi.org/10.1002/9781119943426.ch1