The Changing Face of Research: The Use of Chemical Information Skills to Identify Novel Research Areas

Autor: Madeleine M. Joullié, Judith N. Currano

Publikováno v: Journal of Chemical Education. 98:3110-3117

An experiment in teaching students to use the literature to devise and defend a plan for novel research is presented as part of a graduate-level course in heterocyclic chemistry. Students in three successive iterations of the course completed an assi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5e041292204c7abe957d8c886b4a9b91
https://doi.org/10.1021/acs.jchemed.1c00677

Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space

Autor: Rajarshi Guha, Anton Simeonov, Jesus Moreno, Min Shen, Yi Tang, James Inglese, Jared T. Shaw, Jimmy Ming-Tai Wu, Samir A. Ross, Tobie D. Lee, Surendra Karavadhi, Dorian M. Cheff, Susruta Majumdar, Adam Yasgar, Richard E. Taylor, Sam Michael, Zhengren Xu, Wei Sun, Lucas A. Morrill, David A. Vosburg, Wei Zheng, Corey R. J. Stephenson, Noah Z. Burns, Michael J. Iannotti, Carleen Klumpp-Thomas, Richard T. Eastman, Ohyun Kwon, Armen Zakarian, Yufeng Zhang, Matthew D. Hall, Sara E. Kearney, Ya Qin Zhang, Tongan Zhao, Ken Cheng, Indrajeet Sharma, Nathan P. Coussens, Ruili Huang, Derek S. Tan, Paul Shinn, Michael J. Krische, Caitlin Lynch, Jon Clardy, Larry E. Overman, Kanny K. Wan, Chambers C. Hughes, Madeleine M. Joullié, Thomas J. Maimone, Matthew B. Boxer, Jason A. Clement, A. Douglas Kinghorn, Peter A. Crooks, Brian C. Goess, Robert B. Susick, Gergely Zahoránszky-Kőhalmi, Alyssa L. Verano, Danielle Bougie, Jacob S. Roth, Ben Shen, Dorjbal Dorjsuren, Elias Picazo, Jinghua Zhao, John K. Snyder, Rodrigo B. Andrade, Wei Shi, Jin K. Cha, Brian T. Murphy, Fatima Rivas, William M. Wuest, Jake Ganor, Robert B. Grossman, Pavel Nagorny, Emily Mevers, Enas I. Mohamed, David E. Olson, John A. Porco, Neil K. Garg, Srilatha Sakamuru, Jason M. Rohde, M. Kevin Brown, Menghang Xia, Tianjing Ren, Steve Titus, Christopher Dillon, Mark J. Henderson, Zhong Zuo, Regan J. Thomson, David G. I. Kingston, Lauren E. Brown, Jeffrey N. Johnston, Katherine N. Maloney, Richmond Sarpong, Zina Itkin, Gregory D. Cuny, Ajit Jadhav, Kyle R. Brimacombe

Publikováno v: ACS Central Science
ACS Central Science, Vol 4, Iss 12, Pp 1727-1741 (2018)

Natural products and their derivatives continue to be wellsprings of nascent therapeutic potential. However, many laboratories have limited resources for biological evaluation, leaving their previously isolated or synthesized compounds largely or com

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04c15680292ccf77cdc7f1e4318e2861
http://europepmc.org/articles/PMC6311695

A Transannular Rearrangement Reaction of a Pyrroloindoline Diketopiperazine

Autor: Qiao Yan, Jeffrey D. Winkler, Madeleine M. Joullié, Michael R. Gau, Patrick J. Carroll

Publikováno v: Organic letters. 21(17)

Oxaline, glandicoline, and meleagrin contain a unique triazaspirocyclic structure. Attracted by their biological activities, we attempted a novel strategy, mimicking a proposed biosynthetic pathway for glandicoline B in Penicillium chrysogenum and Pe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::450a5c298cdf2208bfcb00a30ddedcb5
https://pubmed.ncbi.nlm.nih.gov/31414824

Joining Forces: Fermentation and Organic Synthesis for the Production of Complex Heterocycles

Autor: Claire M. Gober, Madeleine M. Joullié

Publikováno v: The Journal of Organic Chemistry. 81:10136-10144

Commercial application of many promising heterocyclic natural products is limited by their natural abundance. While organic synthesis provides access to many natural products, total synthesis of numerous complex molecules is not economically feasible

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f176806be6ff3210048f9d070c30056
https://doi.org/10.1021/acs.joc.6b01308

Total synthesis of the reported structure of ceanothine D

Autor: Jisun, Lee, Madeleine M, Joullié

Publikováno v: Chemical Science

A novel regio- and stereocontrolled macrocyclization strategy was developed for the first synthesis of ceanothine D.
The first total synthesis of the reported structure of ceanothine D, a cyclopeptide alkaloid found in red root, was achieved usi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8a9def183491f3deed2024b511032757
https://pubmed.ncbi.nlm.nih.gov/29732118