Zobrazeno 1 - 10
of 1 378
pro vyhledávání: '"and K. Kaneko"'
Publikováno v:
Biochemistry and Biophysics Reports, Vol 40, Iss , Pp 101824- (2024)
Leukocyte migration is an essential function of innate and adaptive immune responses. Chemokines and their receptors control the migration system. The abundance of chemokines is controlled by atypical chemokine receptors (ACKRs), chemokine receptor-l
Externí odkaz:
https://doaj.org/article/98bfc38004d448688eb4c31600ffc92f
Publikováno v:
Cells, Vol 13, Iss 22, p 1833 (2024)
Podoplanin (PDPN) overexpression is associated with poor clinical outcomes in various tumors. PDPN is involved in malignant tumor progression by promoting invasiveness and metastasis. Therefore, PDPN is considered a promising target of monoclonal ant
Externí odkaz:
https://doaj.org/article/f26ba874b8574c9ab6484a3e2102a139
Autor:
Tetsuya Inoue, Yuichiro Yamamoto, Kaoru Sato, Yuko Okemoto-Nakamura, Yoshimi Shimizu, Motohiko Ogawa, Taishi Onodera, Yoshimasa Takahashi, Takaji Wakita, Mika K. Kaneko, Masayoshi Fukasawa, Yukinari Kato, Kohji Noguchi
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109363- (2024)
Summary: A current challenge is the emergence of SARS-CoV-2 variants, such as BQ.1.1 and XBB.1.5, that can evade immune defenses, thereby limiting antibody drug effectiveness. Emergency-use antibody drugs, including the widely effective bebtelovimab,
Externí odkaz:
https://doaj.org/article/249593eb8a2848489d26e0422c0f2000
Autor:
Kohdai Yamada, Ryouhei Shioya, Kohei Nishino, Hirotake Furihata, Atsushi Hijikata, Mika K. Kaneko, Yukinari Kato, Tsuyoshi Shirai, Hidetaka Kosako, Tatsuya Sawasaki
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Receptor proteins, such as epidermal growth factor receptor (EGFR), interact with other proteins in the extracellular region of the cell membrane to drive intracellular signalling. Therefore, analysis of extracellular protein-protein interac
Externí odkaz:
https://doaj.org/article/e1786466eff242848bf775caca410fb3
Publikováno v:
Current Issues in Molecular Biology, Vol 45, Iss 10, Pp 7734-7748 (2023)
The clinically approved human epidermal growth factor receptor 2 (HER2)-targeting monoclonal antibodies (mAbs), trastuzumab, and pertuzumab, target domains IV and II, respectively. Trastuzumab is now the standard treatment for HER2-overexpressed brea
Externí odkaz:
https://doaj.org/article/d81dcae4187f4e6dbb684db1d0f8414e
Publikováno v:
International Journal of Translational Medicine, Vol 3, Iss 3, Pp 310-320 (2023)
Overexpression of human epidermal growth factor receptor 2 (HER2) in breast cancer is an important target of monoclonal antibody (mAb) therapy such as trastuzumab. Due to the development of trastuzumab–deruxtecan, an antibody-drug conjugate, the ta
Externí odkaz:
https://doaj.org/article/4c332c7e83c840de9d833484bd215280
Autor:
Megumi Kaji, Yukiko K. Kaneko, Stella Amarachi Ihim, Ran Kanoh, Moe Yamamoto, Momoka Yamaguchi, Tomohisa Ishikawa
Publikováno v:
Frontiers in Nutrition, Vol 10 (2024)
IntroductionNobiletin is a polymethoxyflavonoid abundant in citrus peels and has been reported to have various bioactive effects. We have previously reported that nobiletin inhibits endoplasmic reticulum stress-induced apoptosis in the pancreatic β-
Externí odkaz:
https://doaj.org/article/cefd470eca1545a4bf29a0362286918a
Neutron resonance absorption imaging of simulated high-level radioactive waste in borosilicate glass
Autor:
Y. Oba, R. Motokawa, K. Kaneko, T. Nagai, Y. Tsuchikawa, T. Shinohara, J. D. Parker, Y. Okamoto
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-8 (2023)
Abstract We performed a preliminary study of neutron resonance absorption imaging to investigate the spatial distribution of constituent elements in borosilicate glasses containing simulated high-level radioactive waste, in which elemental inhomogene
Externí odkaz:
https://doaj.org/article/74a2b0286d6342c7be74a6f358ded869
Publikováno v:
Current Issues in Molecular Biology, Vol 45, Iss 7, Pp 5248-5262 (2023)
Head and neck squamous cell carcinoma (HNSCC) is the most common type of head and neck cancer, and has been revealed as the second-highest expression of CD44 in cancers. CD44 has been investigated as a cancer stem cell marker of HNSCC and plays a cri
Externí odkaz:
https://doaj.org/article/14c0cc8fc3924c9d92e350b3c1645e1e
Autor:
Shoma Nishibori, Mika K. Kaneko, Takayuki Nakagawa, Kazuo Nishigaki, Yukinari Kato, Masaya Igase, Takuya Mizuno
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Antibodies against immune checkpoint molecules restore T-cell function by inhibiting the binding of PD-1 and PD-L1 and have been shown to exert therapeutic effects in various human cancers. However, to date, no monoclonal antibody that recog
Externí odkaz:
https://doaj.org/article/5dd07ae6c7cb40cfb93bf98cbdc50815