Ethylene Vinyl Alcohol Copolymer Nanofibrous Cation Exchange Chromatographic Membranes with a Gradient Porous Structure for Lysozyme Separation

Autor: Tianzhi Tang, Jinping Gan, Zhanrui Cao, Pan Cheng, Qin Cheng, Tao Mei, Liping Zhu, Feng Zhou, Ke Liu, Dong Wang

Publikováno v: Polymers, Vol 16, Iss 8, p 1112 (2024)

Lysozyme, a common antimicrobial agent, is widely used in the food, biopharmaceutical, chemical, and medicine fields. Rapid and effective isolation of lysozymes is an everlasting topic. In this work, ethylene vinyl alcohol (EVOH) copolymer nanofibrou

Externí odkaz: https://doaj.org/article/caec7791595c463c818999bc1728cc20

Tissue distribution and tumor uptake of folate receptor–targeted epothilone folate conjugate, BMS-753493, in CD2F1 mice after systemic administration

Autor: Hong Shen, Lifei Wang, Weiqi Chen, Krista Menard, Yang Hong, Yuan Tian, Samuel J. Bonacorsi, W. Griffith Humphreys, Francis Y. Lee, Jinping Gan

Publikováno v: Acta Pharmaceutica Sinica B, Vol 6, Iss 5, Pp 460-467 (2016)

To assess targeting of an epothilone folate conjugate (BMS-753493) to the folate receptor (FR)-overexpressed tumor in mice bearing both FR+ and FR– tumors, a series of experiments were conducted by quantitative whole-body autoradiography (QWBA) and

Externí odkaz: https://doaj.org/article/ebd2251cedc4474c92e66080f6b9bb62

Contributors

Autor: Rick Adler, Famke Aeffner, Laura E. Armstrong, Dmitri Artemov, Adam D. Aulbach, Bindu M. Bennet, Eric A. Blomme, Brad Bolon, Christopher J. Bowman, Molly Boyle, Alys Bradley, Dino Bradley, Danielle Brown, Pierre R. Bushel, Ellen Cannady, Mark F. Cesta, Curtis Chan, Jennifer A. Chilton, Peter J.M. Clements, Torrie A. Crabbs, Myrtle A. Davis, Sandy Eldridge, Daniela Ennulat, Jeffrey Everitt, Isabel Figueroa, James D. Fikes, Thomas Forest, Catherine A. Foss, John R. Foster, Kathleen Gabrielson, Shayne C. Gad, Kapil Gadkar, Jinping Gan, David Garcia-Tapia, Frank J. Geoly, Wendy G. Halpern, Jerry F. Hardisty, Wanda M. Haschek, Kathleen Marie Heinz-Taheny, Kristi Helke, Lauren E. Himmel, Mark J. Hoenerhoff, Jennifer L. Ingram–Ross, Armando R. Irizarry Rovira, Evan B. Janovitz, Kishore Katyayan, Charlotte M. Keenan, Angela King-Herbert, Steven T. Laing, Lois D. Lehman-McKeeman, Na Li, Calvert Louden, Claire Lyons, Kevin McDorman, Elizabeth McInnes, Lyn Miller Wancket, Sheroy Minocherhomji, Sébastien Monette, James Morrison, Vasanthi Mowat, Sydney Mukaratirwa, Keith Nelson, Arun R. Pandiri, Tracey Papenfuss, Nita Patel, Daniel J. Patrick, Shari A. Price, Deepa B. Rao, James T. Raymond, Jennifer Rojko, Colin G. Rousseaux, Sara F. Santagostino, Aaron Sargeant, Christina Satterwhite, A. Eric Schultze, Vanessa Schumacher, Cheryl Scudamore, Keith R. Shockley, Bhanu P. Singh, David M. Stresser, Polina Sysa-Shah, Debra A. Tokarz, Terry Van Vleet, Matthew A. Wallig, Jin Wang, Cynthia J. Willson, Kristin Lewis Wilson, Christopher T. Winkelmann, Jeffrey C. Wolf, Charles Wood, Daniela Bumbaca Yadav, Mark Zarella

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c3831ed61c4599a4d47034bfb7e19d99
https://doi.org/10.1016/b978-0-12-821044-4.01002-5

Perspectives on the evaluation and adoption of complex in vitro models in drug development: Workshop with the FDA and the pharmaceutical industry (IQ MPS Affiliate)

Autor: Szczepan W, Baran, Paul C, Brown, Andreas R, Baudy, Suzanne C, Fitzpatrick, Christopher, Frantz, Aaron, Fullerton, Jinping, Gan, Rhiannon N, Hardwick, Kathleen M, Hillgren, Anna K, Kopec, Jennifer L, Liras, Donna L, Mendrick, Ryan, Nagao, William R, Proctor, Diane, Ramsden, Alexandre J S, Ribeiro, David, Stresser, Kyung E, Sung, Radhakrishna, Sura, Kazuhiro, Tetsuka, Lindsay, Tomlinson, Terry, Van Vleet, Matthew P, Wagoner, Qin, Wang, Sevim Yildiz, Arslan, Gorm, Yoder, Jason E, Ekert

Publikováno v: ALTEX.

Complex in vitro models (CIVM) offer the potential to improve pharmaceutical clinical drug attrition due to safety and/ or efficacy concerns. For this technology to have an impact, the establishment of robust characterization and qualifi­cation plan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::991b82190055f9a932fb29fb1692bafd
https://doi.org/10.14573/altex.2112203

Phase I study of HFB200301, a first-in-class TNFR2 agonist monoclonal antibody in patients with solid tumors selected via Drug Intelligent Science (DIS)

Autor: Alexander I. Spira, Aung Naing, Hani M. Babiker, Mitesh J. Borad, Elena Garralda, Konstantinos Leventakos, Peter John Oppelt, Desamparados Roda, Jon Zugazagoitia, Christos Hatzis, Margaret Chen, Jinping Gan, Andreas Raue, Francisco Adrian, Luigi Manenti, Anthony B. El-Khoueiry

Publikováno v: Journal of Clinical Oncology. 40:TPS2670-TPS2670

TPS2670 Background: Tumor necrosis factor receptor-2 (TNFR2) is expressed on effector CD8+ T cells, CD4+ T cells, T regulatory cells, natural killer cells, and myeloid cells. Targeting TNFR2 is anticipated to yield effective anti-tumor immunity by st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d656d5f33ebdd010a10b35615ddf1a5e
https://doi.org/10.1200/jco.2022.40.16_suppl.tps2670