Zobrazeno 1 - 10
of 345
pro vyhledávání: '"and Jacques H. van Boom"'
Autor:
Jacques H. Van Boom, Gijsbert A. van der Marel, Wolfgang Pfleiderer, Silvia Cavalli, D.V. (Dmitri) Filippov, Gerard Voerman
Publikováno v:
Journal of Natural Products. 68:938-941
Two previously unknown lumazine derivatives, 1 and 2, have been isolated from the parasitic freshwater leech Limnatis nilotica. The structures of the compounds have been elucidated by NMR and unambiguously corroborated by chemical synthesis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19d72cb769c67789914c42ccb967b41b
https://doi.org/10.1021/np049617a
https://doi.org/10.1021/np049617a
Autor:
Herman S. Overkleeft, Steven van Zutphen, Jan Reedijk, C Marco Timmers, Reynier A. Tromp, Jacques H. van Boom, Stella S. G. E. van Boom, Gijsbert A. van der Marel
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:4273-4276
The use of platinum drugs in antitumour therapy is well established. An important drawback of these chemotherapeutics is the lack of selectivity for tumour cells, usually resulting in severe toxic side effects. A glucuronyl-platinum conjugate was des
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07d78fb180e1ed154604e9691347e739
https://doi.org/10.1016/j.bmcl.2004.06.015
https://doi.org/10.1016/j.bmcl.2004.06.015
Autor:
Herman S. Overkleeft, Cornelius G. N. Korevaar, Gijsbert A. van der Marel, Richard J. B. H. N. van den Berg, Jacques H. van Boom
Publikováno v:
The Journal of Organic Chemistry. 69:5699-5704
The synthesis of naturally occurring D-erythro-(2R,3S,4E)-sphingosine from commercially available D-ribo-(2S,3S,4R)-phytosphingosine is described. The key step in the reaction sequence comprises TMSI/DBN promoted regio- and stereoselective oxirane op
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3101ee303e54d4338fdcb98114d45dc3
https://doi.org/10.1021/jo049277y
https://doi.org/10.1021/jo049277y
Autor:
Gijs A. van der Marel, Jacques H. van Boom, Carlos González, Modesto Orozco, Elena Cubero, Irene Gómez-Pinto, Susana G. Kalko, Vania Monaco
Publikováno v:
Journal of Biological Chemistry. 279:24552-24560
The three-dimensional solution structure of two DNA decamers of sequence d(CCACXGGAAC)-(GTTCCGGTGG) with a modified nucleotide containing a cholesterol derivative (X) in its C1 ′(chol)α or C1 ′(chol)β diastereoisomer form has been determined by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a13b407805a9da3959b979a826397088
https://doi.org/10.1074/jbc.m311751200
https://doi.org/10.1074/jbc.m311751200
Autor:
Herman S. Overkleeft, Tom Wennekes, Lisette Magnee, Steven H. L. Verhelst, Constant A. A. van Boeckel, Gijsbert A. van der Marel, Wouter Wiedenhof, Jacques H. van Boom
Publikováno v:
European Journal of Organic Chemistry. 2004:2404-2410
In this paper, a glycosylation-based approach towards novel aminoglycoside analogues is presented. Three different cyclitol building blocks were condensed with different thioglycosides to give, after removal of the protective groups, several neamine-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::172845abfb4eb522a491d44b472e53a8
https://doi.org/10.1002/ejoc.200400020
https://doi.org/10.1002/ejoc.200400020
Autor:
Herman S. Overkleeft, Jeroen D. C. Codée, Leendert J. van den Bos, John C. van der Toorn, Thomas J. Boltje, Gijsbert A. van der Marel, Jacques H. van Boom
Publikováno v:
Organic Letters. 6:2165-2168
[reaction: see text] Partially protected thioglycuronic acids are prepared efficiently by chemo- and regioselective oxidation of the corresponding thioglycosides using the TEMPO/BAIB reagent combination. After esterification, the thioglycuronic acids
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::808c805e8b78f7360611df6c41c21261
https://doi.org/10.1021/ol049380+
https://doi.org/10.1021/ol049380+
Autor:
Petra Van Kuik-Romeijn, Jacques H. van Boom, Gijsbert A. van der Marel, Mark Overhand, Jimmy Weterings, Lene Petersen, Christine J. Pol, Martijn C. de Koning, Gerard Johannes Platenburg
Publikováno v:
Bioconjugate Chemistry. 15:576-582
We report the synthesis of novel artificial ribonucleases with potentially improved cellular uptake. The design of trifunctional conjugates 1a and 1b is based on the specific RNA-recognizing properties of PNA, the RNA-cleaving abilities of diethylene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5420ea10881bd7d57d4377fe6739342a
https://doi.org/10.1021/bc034219p
https://doi.org/10.1021/bc034219p
Autor:
Tom Wennekes, Jacques H. van Boom, Gijsbert A. van der Marel, Constant A. A. van Boeckel, Herman S. Overkleeft, Steven H. L. Verhelst
Publikováno v:
Tetrahedron. 60:2813-2822
Enantiomerically pure 4,6-diaminocyclohexenols are obtained from carbohydrate derived 1,7-dienes by ring-closing metathesis and palladium catalyzed allylic amination using o-nitrobenzenesulfonylamides as nucleophiles. In the latter reaction the use o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20ddf744f0dba854012f1aff5f49c0dd
https://doi.org/10.1016/j.tet.2004.01.063
https://doi.org/10.1016/j.tet.2004.01.063