Výsledky vyhledávání - "and J. W. Strohbach"

Structure-Based Design of Novel HIV Protease Inhibitors: Sulfonamide-Containing 4-Hydroxycoumarins and 4-Hydroxy-2-pyrones as Potent Non-Peptidic Inhibitors

Autor: S, Thaisrivongs, M N, Janakiraman, K T, Chong, P K, Tomich, L A, Dolak, S R, Turner, J W, Strohbach, J C, Lynn, M M, Horng, R R, Hinshaw, K D, Watenpaugh

Publikováno v: Journal of Medicinal Chemistry. 39:2400-2410

The low oral bioavailability and rapid biliary excretion of peptide-derived HIV protease inhibitors have limited their utility as potential therapeutic agents. Our broad screening program to discover non-peptidic HIV protease inhibitors previously id

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe175551c1e0beaead1087dbbcdb75b9
https://doi.org/10.1021/jm950888f

Zobrazit plný text záznamu

ChemInform Abstract: Structure-Based Design of Novel HIV Protease Inhibitors: Sulfonamide- Containing 4-Hydroxycoumarins and 4-Hydroxy-2-pyrones as Potent Non- Peptidic Inhibitors

Autor: S. THAISRIVONGS, M. N. JANAKIRAMAN, K.-T. CHONG, P. K. TOMICH, L. A. DOLAK, S. R. TURNER, J. W. STROHBACH, J. C. LYNN, M.-M. HORNG, R. R. HINSHAW, K. D. WATENPAUGH

Publikováno v: ChemInform. 27

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0d2584eaa968566b860dc426844d5780
https://doi.org/10.1002/chin.199638150

Zobrazit plný text záznamu

Structure-based discovery of Tipranavir disodium (PNU-140690E): a potent, orally bioavailable, nonpeptidic HIV protease inhibitor

Autor: S, Thaisrivongs, J W, Strohbach

Publikováno v: Biopolymers. 51(1)

Efforts to develop therapeutically relevant HIV protease inhibitors as medicinal agents in confronting the AIDS crisis have been aided by the wealth of fundamental information acquired during related drug discovery campaigns against other aspartyl pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7e2e8ceebfac27265e4b1f6d5cdafeb9
https://pubmed.ncbi.nlm.nih.gov/10380352

Zobrazit plný text záznamu

Asymmetric Syntheses and Absolute Stereochemistry of 5,6-Dihydro-α-pyrones, A New Class of Potent HIV Protease Inhibitors

Autor: Ronald B. Gammill, and J. W. Strohbach, Thomas M. Judge, Lester A. Dolak, Gillian Phillips, Steve A. Mizsak, R. A. Chrusciel, J. M. Tustin, Joel Morris, S. L. Vander Velde, John Tulinsky, W. Watt, G. P. Luke, K. D. Lovasz, Karen Rene Romines

Publikováno v: Journal of the American Chemical Society. 119:3627-3628

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ce96eea487180a376ab991b30e8fa4c1
https://doi.org/10.1021/ja963434w

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání