Zobrazeno 1 - 10
of 80
pro vyhledávání: '"and J. Andrew MacKay"'
Autor:
Jolinde van Strien, Hans Warmenhoven, Adrian Logiantara, Max Makurat, Lorenz Aglas, Athanasios Bethanis, Romain Leboux, Leonie van Rijt, J. Andrew MacKay, Johannes W. van Schijndel, Gregory Schneider, René Olsthoorn, Wim Jiskoot, Ronald van Ree, Alexander Kros
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
There is growing concern about the toxicity of colloidal aluminum salts used as adjuvants in subcutaneous allergen immunotherapy (SCIT). Therefore, alternative adjuvants and delivery systems are being explored to replace alum in SCIT. We applied mice
Externí odkaz:
https://doaj.org/article/ee4f7a6d5ac74d13b0074cd0865161f4
Autor:
Sara Aly Attia, Anh Tan Truong, Alvin Phan, Shin-Jae Lee, Manal Abanmai, Marinella Markanovic, Hugo Avila, Haozhong Luo, Atham Ali, Parameswaran G. Sreekumar, Ram Kannan, J. Andrew MacKay
Publikováno v:
Antioxidants, Vol 12, Iss 10, p 1817 (2023)
Background: Oxidative stress-induced retinal degeneration is among the main contributing factors of serious ocular pathologies that can lead to irreversible blindness. αB-crystallin (cry) is an abundant component of the visual pathway in the vitreou
Externí odkaz:
https://doaj.org/article/5deb9dd39dfd4dd2a098780ba9fea69d
Publikováno v:
Biomacromolecules. 24:2030-2041
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a146afc3e488cb262536ca239ee69574
https://doi.org/10.1021/acs.biomac.2c01465
https://doi.org/10.1021/acs.biomac.2c01465
Autor:
Hugo Avila, Jingmei Yu, Geetha Boddu, Alvin Phan, Anh Truong, Santosh Peddi, Hao Guo, Shin-Jae Lee, Mario Alba, Ethan Canfield, Vicky Yamamoto, James C. Paton, Adrienne W. Paton, Amy S. Lee, J. Andrew MacKay
Publikováno v:
Biomacromolecules. 23(8)
Rapalogues are powerful therapeutic modalities for breast cancer; however, they suffer from low solubility and dose-limiting side effects. To overcome these challenges, we developed a long-circulating multiheaded drug carrier called 5FA, which contai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cac90614dd03f70e87778f80332ee411
https://pubmed.ncbi.nlm.nih.gov/35786858
https://pubmed.ncbi.nlm.nih.gov/35786858
Publikováno v:
Pharmaceutics, Vol 11, Iss 5, p 221 (2019)
Contact lenses are widely prescribed for vision correction, and as such they are an attractive platform for drug delivery to the anterior segment of the eye. This manuscript explores a novel strategy to drive the reversible adsorption of peptide-base
Externí odkaz:
https://doaj.org/article/3c9bfe41a1f241b0ade1e7bd22776309
Publikováno v:
Adv Drug Deliv Rev
Antibodies possess multiple biologically relevant features that have been engineered into new therapeutic formats. Two examples include the adaptable specificity of their variable (Fv) region and the extension of plasma circulation times through thei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20cd9c926335a578f12e06a31ca1f3eb
https://doi.org/10.1016/j.addr.2020.10.017
https://doi.org/10.1016/j.addr.2020.10.017
Autor:
Hao Guo, Yaping Ju, Minchang Choi, Maria C. Edman, Stan G. Louie, Sarah F. Hamm-Alvarez, J. Andrew MacKay
Publikováno v:
Biomaterials
Sjögren’s syndrome (SS) is a multifactorial autoimmune disease with principal symptoms including inflammation and loss of function of lacrimal glands (LG) and salivary glands. While glandular infiltrates includes both B- and T- cells, CD4+ T cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fb5925dadd931d04d960f28636b8f6d
https://europepmc.org/articles/PMC8982551/
https://europepmc.org/articles/PMC8982551/
Autor:
Sara Aly Attia, J. Andrew MacKay
Publikováno v:
Advanced drug delivery reviews. 188
Hybrid or recombinant protein-polymers, peptide-based biomaterials, and antibody-targeted therapeutics are widely explored for various ocular conditions and vision correction. They have been noted for their potential biocompatibility, potency, adapta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f6cae4558ee65081b4d1eeb7b09545c
https://pubmed.ncbi.nlm.nih.gov/35817213
https://pubmed.ncbi.nlm.nih.gov/35817213
Autor:
Hugo Avila, Anh Truong, David Tyrpak, Shin-Jae Park, Siqi Lei, Yaocun Li, Curtis Okamoto, Sarah Hamm-Alvarez, J. Andrew MacKay
Publikováno v:
Biomacromolecules
Dynamin (DNM) is a family of large GTPases possessing a unique mechanical ability to "pinch" off vesicles entering cells. DNM2 is the most ubiquitously expressed member of the DNM family. We developed a novel tool based on elastin-like polypeptide (E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b549e337ec70ce5afb89ed96d36f207
https://europepmc.org/articles/PMC9159747/
https://europepmc.org/articles/PMC9159747/
Autor:
Santosh Peddi, J. Andrew MacKay, Sarah F. Hamm-Alvarez, Changrim Lee, Stan G. Louie, Frances Yarber, Srikanth Reddy Janga, Siyu Liu, Wannita Klinngam, Nishant Tiwari, Hao Guo, Maria C. Edman
Publikováno v:
Mol Pharm
The USFDA-approved immunosuppressive drug rapamycin (Rapa), despite its potency, is limited by poor bioavailability and a narrow therapeutic index. In this study, we sought to improve bioavailability of Rapa with subcutaneous (SC) administration and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9194015ce75debbd930dad03ae846173
https://doi.org/10.1021/acs.molpharmaceut.9b00263
https://doi.org/10.1021/acs.molpharmaceut.9b00263