Zobrazeno 1 - 10 of 26 pro vyhledávání: '"and Heather K. Webb"'
1
Epoxyeicosatrienoic Acids Prevent Cisplatin-Induced Renal Apoptosis through a p38 Mitogen-Activated Protein Kinase–Regulated Mitochondrial Pathway
Autor: Yingmei Liu, Heather K. Webb, Deanna L. Kroetz, Xiaodan Lu, Sinh Nguyen, Jean L. Olson
Publikováno v: Molecular pharmacology, vol 84, iss 6
Soluble epoxide hydrolase (sEH) catalyzes the conversion of epoxyeicosatrienoic acids into less active eicosanoids, and inhibitors of sEH have anti-inflammatory and antiapoptotic properties. Based on previous observations that sEH inhibition attenuat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dee635b5099886dcd10954480bbe3ff8
https://doi.org/10.1124/mol.113.088302
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2
Pharmacokinetics and Pharmacodynamics of AR9281, an Inhibitor of Soluble Epoxide Hydrolase, in Single- and Multiple-Dose Studies in Healthy Human Subjects
Autor: Vinh Tran, Sampath K. Anandan, Dawn Chen, Zung N. Do, James Sabry, Heather K. Webb, Randall Whitcomb, Richard D. Gless, Euan MacIntyre, Dinesh V. Patel
Publikováno v: Journal of Clinical Pharmacology
Journal of Clinical Pharmacology, Wiley, 2012, 52, pp.319-328
AR9281, a potent and selective inhibitor of soluble epoxide hydrolase (s-EH), is in clinical development targeting hypertension and type 2 diabetes. The safety, pharmacokinetics, and pharmacodynamics of AR9281 were evaluated in double-blind, randomiz
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b409089f9f559f00a6bcd417b7254a57
https://doi.org/10.1177/0091270010397049
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3
Inhibition of soluble epoxide hydrolase attenuates endothelial dysfunction in animal models of diabetes, obesity and hypertension
Autor: Yi-Xin Jim Wang, Richard D. Gless, D. Euan MacIntyre, Gabor Rubanyi, Le-Ning Zhang, Sampath-Kumar Anandan, Heather K. Webb, Dawn Chen, Jon Vincelette
Publikováno v: European Journal of Pharmacology. 654:68-74
Endothelial dysfunction is a hallmark of, and plays a pivotal role in the pathogenesis of cardiometabolic diseases, including type II diabetes, obesity, and hypertension. It has been well established that epoxyeicosatrienoic acids (EETs) act as an en
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3d29c5146e5ae75db5f7f7933f53e62
https://doi.org/10.1016/j.ejphar.2010.12.016
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4
Non-urea functionality as the primary pharmacophore in soluble epoxide hydrolase inhibitors
Autor: Dinesh V. Patel, Zung N. Do, Heather K. Webb, Richard D. Gless, Sampath-Kumar Anandan
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 19:1066-1070
Inhibition of soluble epoxide hydrolase has been proposed as a promising new pharmaceutical target for diseases involving hypertension and vascular inflammation. The most potent sEH inhibitors reported to date contain a urea or amide moiety as the ce
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c617791fe516043df3adab64f954036d
https://doi.org/10.1016/j.bmcl.2009.01.013
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5
Pharmacological Properties of SD-282 – An α-Isoform Selective Inhibitor for p38 MAP Kinase
Autor: Gregory R. Luedtke, Yuanying Anne Huang, Sundeep Dugar, Jose Carlos Chavez, Ramona Almirez, Sarvajit Chakravarty, Cheng Ping Mao, Ann M. Kapoun, Satyanarayana Medicherla, Gladys T. Muiru, Linda S. Higgins, Aaron N. Nguyen, Don Lim, Yu-Wang Liu, Heather K. Webb, Bruce Koppelman, Babu J. Mavunkel, Ying Feng, Andrew A. Protter
Publikováno v: Pharmacology. 81:204-220
The effects of small-molecule p38 inhibitors in numerous models of different disease states have been published, including those of SD-282, an indole-5-carboxamide inhibitor. The aim of the present study was to evaluate the pharmacological activity o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95ddf888b5b53ad1f684ec45b5167e2d
https://doi.org/10.1159/000112865
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6
Inhibiting TGF-β signaling restores immune surveillance in the SMA-560 glioma model
Autor: Glenn Mcenroe, Wolfgang Wick, Alison Murphy, Martin Uhl, Ann M. Kapoun, Andrew Lam, Heather K. Webb, Thomas-Toan Tran, Sundeep Dugar, Jonathan Axon, Steffen Aulwurm, Barry Patrick Hart, Linda S. Higgins, Jing Ying Ma, Venkataraman Sriram, Lisa Janssen, Sarvajit Chakravarty, Michael Weller, Darin E. Kizer, Andrew A. Protter, Darren H. Wong, Irene Kerr
Publikováno v: Neuro-Oncology. 9:259-270
Transforming growth factor-beta (TGF-beta) is a proinvasive and immunosuppressive cytokine that plays a major role in the malignant phenotype of gliomas. One novel strategy of disabling TGF-beta activity in gliomas is to disrupt the signaling cascade
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bdd7196e1e669e29fe4b1c79a10fd8a
https://doi.org/10.1215/15228517-2007-010
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9
1-(N-Alkylamino)-11-(N-ethylamino)-4,8-diazaundecanes: Simple Synthetic Polyamine Analogues That Differentially Alter Tubulin Polymerization
Autor: Nilantha S. Sirisoma, Zhiqian Wu, Patrick M. Woster, Robert A. Casero, Heather K Webb, Hyo Chol Ha
Publikováno v: Journal of Medicinal Chemistry. 42:1415-1421
Polyamine analogues such as bis(ethyl)norspermine and N1-(cyclopropylmethyl)-N11-ethyl-4,8-diazaundecane (CPENSpm) act as potent modulators of cellular polyamine metabolism in vitro and possess impressive antitumor activity against a number of cell l
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7c623b05153044b3285af1e17757a46a
https://doi.org/10.1021/jm980603+
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