Zobrazeno 1 - 10
of 17
pro vyhledávání: '"and Foe S. Tjoeng"'
Autor:
Deborah E. Whipple, Mark E. Zupec, Steven Paul Adams, Derek S. Towery, Foe S. Tjoeng, Kam F. Fok, Mark H. Williams, Joseph W. Bulock
Publikováno v:
International Journal of Peptide and Protein Research. 35:141-146
An automated multiple peptide synthesis method to synthesize, cleave, and purify several peptides simultaneously in a single batch has been developed. The technique is based on the synthesis of multiple peptides on a single solid phase support and is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9366c22b8edf92707b4a8282d8e30611
https://doi.org/10.1111/j.1399-3011.1990.tb00249.x
https://doi.org/10.1111/j.1399-3011.1990.tb00249.x
Autor:
S.G. Panzer-Knodle, Kam F. Fok, Larry P. Feigen, Steven Paul Adams, Nancy S. Nicholson, Foe S. Tjoeng
Publikováno v:
International Journal of Peptide and Protein Research. 38:124-130
Tetrapeptides containing the sequence Arg-Gly-Asp (RGD) antagonize fibrinogen binding to its platelet receptor (gp IIb/IIIa, integrin alpha IIb beta 3) and inhibit platelet aggregation in vitro. The peptides RGDS and RGDY(Me)-NH2 were rapidly degrade
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d67a4cc0688e8be95fbe04ff42431fa
https://doi.org/10.1111/j.1399-3011.1991.tb01419.x
https://doi.org/10.1111/j.1399-3011.1991.tb01419.x
Autor:
Mark G. Currie, Karen B. Peterson, William M. Moore, Pamela T. Manning, Thomas P. Misko, Christine M. Kornmeier, Steven W. Kramer, Jane R. Connor, Gina M. Jerome, Barnett S. Pitzele, Mahima Trivedi, Foe S. Tjoeng, Donald W. Hansen, Ronald Keith Webber
Publikováno v:
Journal of Medicinal Chemistry. 41:1361-1366
An attractive approach to the treatment of inflammatory conditions such as osteo- and rheumatoid arthritis, inflammatory bowel disease, and sepsis is through the selective inhibition of human inducible nitric oxide synthase (hiNOS) since localized ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::681bd0252c2170629f7f44f4fd7f776a
https://doi.org/10.1021/jm9704715
https://doi.org/10.1021/jm9704715
Autor:
William M. Moore, Gina M. Jerome, Foe S. Tjoeng, Mark G. Currie, Kam F. Fok, Christine M. Kornmeier, R. Keith Webber
Publikováno v:
Bioorganic & Medicinal Chemistry. 4:1559-1564
Identification of potent and selective inhibitors of inducible nitric oxide synthase (NOS) is of great interest because of their therapeutic potential for treatment of diseases mediated by excess production of nitric oxide. We present here a comparis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69a60b1b3267e4b84e2f0f8e6698faf9
https://doi.org/10.1016/0968-0896(96)00148-4
https://doi.org/10.1016/0968-0896(96)00148-4
Autor:
and Foe S. Tjoeng, Mark G. Currie, Kam F. Fok, R. Keith Webber, William M. Moore, Pamela T. Manning, Jane R. Connor, Pamela S. Wyatt, Thomas P. Misko, Gina M. Jerome
Publikováno v:
Journal of Medicinal Chemistry. 39:669-672
A series of 2-iminoazaheterocycles have been prepared and shown to be potent inhibitors of human nitric oxide synthase (NOS) isoforms. This series includes cyclic amidines ranging from five- to nine-membered rings, of which 2-iminopiperidine and 2-im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2c3d2fbf2c456f6ca464352f4f27607
https://doi.org/10.1021/jm950766n
https://doi.org/10.1021/jm950766n
Autor:
Dudley E. McMackins, Mihaly V. Toth, Henry E. Dayringer, J. G. Rico, P. R. Bovy, Nancy S. Nicholson, Anita K. Salyers, Beatrice B. Taite, Jeffery Alan Zablocki, Larry P. Feigen, Thomas E. Rogers, Shashidhar N. Rao, Mark E. Zupec, Robert Bruce Garland, Steven Paul Adams, M. Herin, R. J. Lindmark, Foe S. Tjoeng, S.G. Panzer-Knodle, Masateru Miyano
Publikováno v:
Bioorganic & Medicinal Chemistry. 2:881-895
The evolutionary process from the Arg-Gly-Asp-Phe (RGDF) tetrapeptide to potent orally active anti-platelet agents is presented. The RGD sequence is an important component in the recognition of fibrinogen by its platelet receptor GP IIb-IIIa (integri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82ff7ca1e73492c493b88cb344c8d089
https://doi.org/10.1016/s0968-0896(00)82038-6
https://doi.org/10.1016/s0968-0896(00)82038-6
Autor:
Nancy S. Nicholson, J. G. Rico, Kenneth Williams, Foe S. Tjoeng, P. R. Bovy, Lucy W. King, Anita K. Salyers, Lori Ann Schretzman, Beatrice B. Taite, Robert B. Garland, Masateru Miyano, Susan G. Panzer-Knodle, Jeffery A. Zablocki, R. J. Lindmark, Mihaly V. Toth, Dudley E. McMackins, James G. Campion, Mark E. Zupec, Larry P. Feigen, Steven Paul Adams
Publikováno v:
Bioorganicmedicinal chemistry. 3(5)
A novel series of orally active fibrinogen receptor antagonists has been discovered through structural modification of our lead intravenous (iv) antiplatelet agent, 5-(4-amidinophenyl)pentanoyl-Asp-Phe 1 (SC-52012). The Asp-Phe amide bond was removed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::457021deb18f6befd4e2a794535a39c6
https://pubmed.ncbi.nlm.nih.gov/7648203
https://pubmed.ncbi.nlm.nih.gov/7648203
Autor:
Mark H. Williams, Deborah E. Whipple, Mark E. Zupec, Foe S. Tjoeng, Joseph W. Bulock, Derek S. Towery, Kam F. Fok, Steven Paul Adams
Publikováno v:
ChemInform. 21
An automated multiple peptide synthesis method to synthesize, cleave, and purify several peptides simultaneously in a single batch has been developed. The technique is based on the synthesis of multiple peptides on a single solid phase support and is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93d84e44440b2e93deadfd3043e267c3
https://doi.org/10.1002/chin.199023286
https://doi.org/10.1002/chin.199023286
Publikováno v:
Transfusion Science. 15:iv
Novel substituted β amino acid derivatives are provided which inhibit platelet aggregation and intermediates thereof. This invention also pertains to pharmaceutical compositions and methods of using such derivatives.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d43257bafebd0048e3431e491d69bed8
https://doi.org/10.1016/0955-3886(94)90077-9
https://doi.org/10.1016/0955-3886(94)90077-9
Autor:
Philippe R Bovy, Dudley E McMackins, Joseph G Rico, Foe S Tjoeng, Mihaly V Toth, Robert Garland, Masateru Miyano, Jeffery A Zablocki
Publikováno v:
Transfusion Science. 14:ii
This invention relates to compounds having the following formula ##STR1## or a pharmaceutically acceptable salt which are useful in the inhibition of platelet aggregation. This invention also relates to pharmaceutical compositions--of such phenyl ami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1df27e5a37833bd7988da71b7d8179f
https://doi.org/10.1016/s0955-3886(05)80024-4
https://doi.org/10.1016/s0955-3886(05)80024-4