Zobrazeno 1 - 10
of 1 128
pro vyhledávání: '"and David A. Owen"'
Autor:
Stergios Tsartsalis, Hannah Sleven, Nurun Fancy, Frank Wessely, Amy M. Smith, Nanet Willumsen, To Ka Dorcas Cheung, Michal J. Rokicki, Vicky Chau, Eseoghene Ifie, Combiz Khozoie, Olaf Ansorge, Xin Yang, Marion H. Jenkyns, Karen Davey, Aisling McGarry, Robert C. J. Muirhead, Stephanie Debette, Johanna S. Jackson, Axel Montagne, David R. Owen, J. Scott Miners, Seth Love, Caleb Webber, M. Zameel Cader, Paul M. Matthews
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Brain perfusion and blood-brain barrier (BBB) integrity are reduced early in Alzheimer’s disease (AD). We performed single nucleus RNA sequencing of vascular cells isolated from AD and non-diseased control brains to characterise pathologic
Externí odkaz:
https://doaj.org/article/6d33fcf5b51e487193ad2c53717ad721
Autor:
Erik Nutma, Nurun Fancy, Maria Weinert, Stergios Tsartsalis, Manuel C. Marzin, Robert C. J. Muirhead, Irene Falk, Marjolein Breur, Joy de Bruin, David Hollaus, Robin Pieterman, Jasper Anink, David Story, Siddharthan Chandran, Jiabin Tang, Maria C. Trolese, Takashi Saito, Takaomi C. Saido, Katharine H. Wiltshire, Paula Beltran-Lobo, Alexandra Phillips, Jack Antel, Luke Healy, Marie-France Dorion, Dylan A. Galloway, Rochelle Y. Benoit, Quentin Amossé, Kelly Ceyzériat, Aurélien M. Badina, Enikö Kövari, Caterina Bendotti, Eleonora Aronica, Carola I. Radulescu, Jia Hui Wong, Anna M. Barron, Amy M. Smith, Samuel J. Barnes, David W. Hampton, Paul van der Valk, Steven Jacobson, Owain W. Howell, David Baker, Markus Kipp, Hannes Kaddatz, Benjamin B. Tournier, Philippe Millet, Paul M. Matthews, Craig S. Moore, Sandra Amor, David R. Owen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-25 (2023)
Abstract Microglial activation plays central roles in neuroinflammatory and neurodegenerative diseases. Positron emission tomography (PET) targeting 18 kDa Translocator Protein (TSPO) is widely used for localising inflammation in vivo, but its quanti
Externí odkaz:
https://doaj.org/article/6e4226618e024c669f4f230499a8801b
Autor:
David Lloyd Owen
Publikováno v:
River, Vol 2, Iss 1, Pp 21-29 (2023)
Abstract Smart water enables utilities, regulators, and customers to make more timely and informed decisions about how they use and regard their water resources. It has been developed to assist demand management by influencing customer behavior and r
Externí odkaz:
https://doaj.org/article/041d1e960b084d069e89ce84b1ae32e5
Autor:
Mohammad Mahmud, Charles Wade, Sarah Jawad, Zaeem Hadi, Christian Otoul, Rafal M. Kaminski, Pierandrea Muglia, Irena Kadiu, Eugenii Rabiner, Paul Maguire, David R. Owen, Michael R. Johnson
Publikováno v:
Frontiers in Neuroimaging, Vol 2 (2023)
ObjectiveTranslocator protein (TSPO) targeting positron emission tomography (PET) imaging radioligands have potential utility in epilepsy to assess the efficacy of novel therapeutics for targeting neuroinflammation. However, previous studies in healt
Externí odkaz:
https://doaj.org/article/8ac866fbfb8544ee9f7ba34f2fbbf4c0
Autor:
Alex J. Szubert, Katrina M. Pollock, Hannah M. Cheeseman, Jasmini Alagaratnam, Henry Bern, Olivia Bird, Marta Boffito, Ruth Byrne, Tom Cole, Catherine A. Cosgrove, Saul N. Faust, Sarah Fidler, Eva Galiza, Hana Hassanin, Mohini Kalyan, Vincenzo Libri, Leon R. McFarlane, Ana Milinkovic, Jessica O'Hara, David R. Owen, Daniel Owens, Mihaela Pacurar, Tommy Rampling, Simon Skene, Alan Winston, James Woolley, Yee Ting N. Yim, David T. Dunn, Sheena McCormack, Robin J. Shattock
Publikováno v:
EClinicalMedicine, Vol 56, Iss , Pp 101823- (2023)
Summary: Background: Lipid nanoparticle (LNP) encapsulated self-amplifying RNA (saRNA) is well tolerated and immunogenic in SARS-CoV-2 seronegative and seropositive individuals aged 18–75. Methods: A phase 2a expanded safety and immunogenicity stud
Externí odkaz:
https://doaj.org/article/8c3e3b38ed0a4f79b89d74a152895c3b
Autor:
David H. Owen, Diana M. Perriman, Igor Policinski, Maurizio Damiani, Paul N. Smith, Chris J. Roberts
Publikováno v:
BMC Musculoskeletal Disorders, Vol 22, Iss 1, Pp 1-6 (2021)
Abstract Background It is controversial whether or not the carpometacarpal joint (CMCJ) should be included in total wrist arthrodesis (TWA). Complications commonly occur at this site and studies examining its inclusion and exclusion are conflicting.
Externí odkaz:
https://doaj.org/article/187fb9279b744f218b6079239d28fb45
Autor:
Claire M. Patterson, Srividya B. Balachander, Iain Grant, Petar Pop-Damkov, Brian Kelly, William McCoull, Jeremy Parker, Michael Giannis, Kathryn J. Hill, Francis D. Gibbons, Edward J. Hennessy, Paul Kemmitt, Alexander R. Harmer, Sonya Gales, Stuart Purbrick, Sean Redmond, Matthew Skinner, Lorraine Graham, J. Paul Secrist, Alwin G. Schuller, Shenghua Wen, Ammar Adam, Corinne Reimer, Justin Cidado, Martin Wild, Eric Gangl, Stephen E. Fawell, Jamal Saeh, Barry R. Davies, David J. Owen, Marianne B. Ashford
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Claire Patterson et al. present the design and development of AZD0466, a drug-dendrimer conjugate, and use preclinical and mathematical models to determine the optimal release rate of the drug from the dendrimer carrier for maximal therapeutic index
Externí odkaz:
https://doaj.org/article/722de1f4d6464ec9a94bce51fe4fc356
Autor:
Harriet Crawley-Snowdon, Ji-Chun Yang, Nathan R. Zaccai, Luther J. Davis, Lena Wartosch, Emily K. Herman, Nicholas A. Bright, James S. Swarbrick, Brett M. Collins, Lauren P. Jackson, Matthew N. J. Seaman, J. Paul Luzio, Joel B. Dacks, David Neuhaus, David J. Owen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
VARP is bound to endosomes and functions as a protein:protein interaction platform. Here, the authors present the NMR structure of the complex between the retromer subunit VPS29 and a VARP Zn-fingernail microdomain that is structurally distinct from
Externí odkaz:
https://doaj.org/article/5179c14a82ba4080bfd7a8f14df6270f
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
The concept that a subset of T cells exists that specifically suppresses immune responses was originally proposed over 50 years ago. It then took the next 30 years to solidify the concept of regulatory T cells (Tregs) into the paradigm we understand
Externí odkaz:
https://doaj.org/article/d6db43e9cf1b40ae8dd460864f0a1865
Autor:
Diana C de Oliveira, David G Owen, Shuang Qian, Naomi C Green, Daniel M Espino, Duncan E T Shepherd
Publikováno v:
PLoS ONE, Vol 16, Iss 2, p e0247438 (2021)
Central venous catheters are widely used in haemodialysis therapy, having to respect design requirements for appropriate performance. These are placed within the right atrium (RA); however, there is no prior computational study assessing different ca
Externí odkaz:
https://doaj.org/article/c2403da5698b4d99b65d4dcdb480d069