Zobrazeno 1 - 10
of 68
pro vyhledávání: '"and Colin P. Johnson"'
Autor:
Ellen Knight, Heiko Balzter, Tom D. Breeze, Julia Brettschneider, Robbie D. Girling, Alex Hagen‐Zanker, Mike Image, Colin G. Johnson, Christopher Lee, Andrew Lovett, Sergei Petrovskii, Alexa Varah, Mick Whelan, Shengxiang Yang, Emma Gardner
Publikováno v:
Methods in Ecology and Evolution, Vol 15, Iss 11, Pp 2153-2167 (2024)
Abstract Spatial modelling approaches to aid land‐use decisions which benefit both wildlife and humans are often limited to the comparison of pre‐determined landscape scenarios, which may not reflect the true optimum landscape for any end‐user.
Externí odkaz:
https://doaj.org/article/5c91a140fbfa430aaee4e89fa4a1d99c
Autor:
Robert Atkinson, Maria Georgiou, Chunbo Yang, Katarzyna Szymanska, Albert Lahat, Elton J. R. Vasconcelos, Yanlong Ji, Marina Moya Molina, Joseph Collin, Rachel Queen, Birthe Dorgau, Avril Watson, Marzena Kurzawa-Akanbi, Ross Laws, Abhijit Saxena, Chia Shyan Beh, Chileleko Siachisumo, Franziska Goertler, Magdalena Karwatka, Tracey Davey, Chris F. Inglehearn, Martin McKibbin, Reinhard Lührmann, David H. Steel, David J. Elliott, Lyle Armstrong, Henning Urlaub, Robin R. Ali, Sushma-Nagaraja Grellscheid, Colin A. Johnson, Sina Mozaffari-Jovin, Majlinda Lako
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract The carboxy-terminus of the spliceosomal protein PRPF8, which regulates the RNA helicase Brr2, is a hotspot for mutations causing retinitis pigmentosa-type 13, with unclear role in human splicing and tissue-specificity mechanism. We used pat
Externí odkaz:
https://doaj.org/article/543dcbabd0154436a3a7c83f1dd4c6bd
Autor:
Tara Gomes, Mina Tadrous, Sophie A Kitchen, Frank Crichlow, Tonya J Campbell, Cynthia Damba, Colin H Johnson, Ashley Smoke
Publikováno v:
BMJ Public Health, Vol 2, Iss 1 (2024)
Introduction The North American toxic drug crisis has been framed as an epidemic primarily affecting white people. However, evidence suggests that deaths are rising among racialised people. Accordingly, we sought to describe and compare characteristi
Externí odkaz:
https://doaj.org/article/0358575f44fa4385b8facc3b5181d1bf
Autor:
Suvina Amin, Seongjung Joo, Sandra Nolte, Hyun Kyoo Yoo, Nikunj Patel, Hilary F. Byrnes, Sara Costa-Cabral, Colin D. Johnson
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-8 (2022)
Abstract Background Metastatic pancreatic cancer (mPC) and its treatments significantly impact health-related quality of life (HRQoL). POLO, a randomized, double-blind, placebo-controlled phase 3 trial evaluated the efficacy of olaparib as maintenanc
Externí odkaz:
https://doaj.org/article/5430453a72cb4ba8be75da4cb7c581fa
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract Skeletal muscle satellite cells cultured on soft surfaces (12 kPa) show improved differentiation than cells cultured on stiff surfaces (approximately 100 kPa). To better understand the reasons for this, we performed an RNA-Seq analysis for a
Externí odkaz:
https://doaj.org/article/e8b6e21f1c0e4785bf3fe7dd5051a8ad
Publikováno v:
Materials Today Bio, Vol 17, Iss , Pp 100502- (2022)
Tissue patterning is the result of complex interactions between transcriptional programs and various mechanical cues that modulate cell behaviour and drive morphogenesis. Vertebrate Hedgehog signalling plays key roles in embryogenesis and adult tissu
Externí odkaz:
https://doaj.org/article/bc73bb9078464564b2fa0512bf8a8485
Autor:
Maria Georgiou, Chunbo Yang, Robert Atkinson, Kuan‐Ting Pan, Adriana Buskin, Marina Moya Molina, Joseph Collin, Jumana Al‐Aama, Franziska Goertler, Sebastian E. J. Ludwig, Tracey Davey, Reinhard Lührmann, Sushma Nagaraja‐Grellscheid, Colin A. Johnson, Robin Ali, Lyle Armstrong, Viktor Korolchuk, Henning Urlaub, Sina Mozaffari‐Jovin, Majlinda Lako
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 3, Pp n/a-n/a (2022)
Abstract Introduction Mutations in pre‐mRNA processing factor 31 (PRPF31), a core protein of the spliceosomal tri‐snRNP complex, cause autosomal‐dominant retinitis pigmentosa (adRP). It has remained an enigma why mutations in ubiquitously expre
Externí odkaz:
https://doaj.org/article/d0deada325104e39a8d523ef7fabc4d6
Autor:
Katarzyna Szymanska, Karsten Boldt, Clare V Logan, Matthew Adams, Philip A Robinson, Marius Ueffing, Elton Zeqiraj, Gabrielle Wheway, Colin A Johnson
Publikováno v:
eLife, Vol 11 (2022)
Primary ciliary defects cause a group of developmental conditions known as ciliopathies. Here, we provide mechanistic insight into ciliary ubiquitin processing in cells and for mouse model lacking the ciliary protein Mks1. In vivo loss of Mks1 sensit
Externí odkaz:
https://doaj.org/article/f0a156367f2e4541b9bddcf0e0c9f9f4
Autor:
Alistair A. Sellar, Colin G. Jones, Jane P. Mulcahy, Yongming Tang, Andrew Yool, Andy Wiltshire, Fiona M. O'Connor, Marc Stringer, Richard Hill, Julien Palmieri, Stephanie Woodward, Lee deMora, Till Kuhlbrodt, Steven T. Rumbold, Douglas I. Kelley, Rich Ellis, Colin E. Johnson, Jeremy Walton, Nathan Luke Abraham, Martin B. Andrews, Timothy Andrews, Alex T. Archibald, Ségolène Berthou, Eleanor Burke, Ed Blockley, Ken Carslaw, Mohit Dalvi, John Edwards, Gerd A. Folberth, Nicola Gedney, Paul T. Griffiths, Anna B. Harper, Maggie A. Hendry, Alan J. Hewitt, Ben Johnson, Andy Jones, Chris D. Jones, James Keeble, Spencer Liddicoat, Olaf Morgenstern, Robert J. Parker, Valeriu Predoi, Eddy Robertson, Antony Siahaan, Robin S. Smith, Ranjini Swaminathan, Matthew T. Woodhouse, Guang Zeng, Mohamed Zerroukat
Publikováno v:
Journal of Advances in Modeling Earth Systems, Vol 11, Iss 12, Pp 4513-4558 (2019)
Abstract We document the development of the first version of the U.K. Earth System Model UKESM1. The model represents a major advance on its predecessor HadGEM2‐ES, with enhancements to all component models and new feedback mechanisms. These includ
Externí odkaz:
https://doaj.org/article/fc137c7dd8bf42a8b59ad5054a5e9f9c
Autor:
Aayushi Manchanda, Paroma Chatterjee, Josephine A. Bonventre, Derik E. Haggard, Katie S. Kindt, Robert L. Tanguay, Colin P. Johnson
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Abstract The protein otoferlin plays an essential role at the sensory hair cell synapse. Mutations in otoferlin result in deafness and depending on the species, mild to strong vestibular deficits. While studies in mouse models suggest a role for otof
Externí odkaz:
https://doaj.org/article/693738f5c51b414bb53355b64b318d18