Zobrazeno 1 - 10
of 422
pro vyhledávání: '"and Ashutosh Chilkoti"'
Autor:
Soumen Saha, Samagya Banskota, Parisa Yousefpour, Jeffrey L. Schaal, Nikita Zakharov, Jianqiao Liu, Michael Dzuricky, Ziwei He, Stefan Roberts, Xinghai Li, Ashutosh Chilkoti
Publikováno v:
Small Science, Vol 4, Iss 11, Pp n/a-n/a (2024)
Nab‐paclitaxel (Abraxane), an albumin‐bound solvent‐free paclitaxel (PTX) formulation that takes advantage of the endogenous albumin transport pathway, is the current gold standard for treatment of solid tumors with PTX. However, nab‐paclitax
Externí odkaz:
https://doaj.org/article/f24ec2aa4c224b659763f6bcc87b8c31
Autor:
Nicholas C. Tang, Jonathan C. Su, Yulia Shmidov, Garrett Kelly, Sonal Deshpande, Parul Sirohi, Nikhil Peterson, Ashutosh Chilkoti
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract We report the de novo design of small (
Externí odkaz:
https://doaj.org/article/5f630e31a4f646b08a4dd05817b2169c
Autor:
Shankar Subramaniam, Metin Akay, Mark A. Anastasio, Vasudev Bailey, David Boas, Paolo Bonato, Ashutosh Chilkoti, Jennifer R. Cochran, Vicki Colvin, Tejal A. Desai, James S. Duncan, Frederick H. Epstein, Stephanie Fraley, Cecilia Giachelli, K. Jane Grande-Allen, Jordan Green, X. Edward Guo, Isaac B. Hilton, Jay D. Humphrey, Chris R Johnson, George Karniadakis, Michael R. King, Robert F. Kirsch, Sanjay Kumar, Cato T. Laurencin, Song Li, Richard L. Lieber, Nigel Lovell, Prashant Mali, Susan S. Margulies, David F. Meaney, Brenda Ogle, Bernhard Palsson, Nicholas A. Peppas, Eric J. Perreault, Rick Rabbitt, Lori A. Setton, Lonnie D. Shea, Sanjeev G. Shroff, Kirk Shung, Andreas S. Tolias, Marjolein C.H. van der Meulen, Shyni Varghese, Gordana Vunjak-Novakovic, John A. White, Raimond Winslow, Jianyi Zhang, Kun Zhang, Charles Zukoski, Michael I. Miller
Publikováno v:
IEEE Open Journal of Engineering in Medicine and Biology, Vol 5, Pp 1-13 (2024)
Over the past two decades Biomedical Engineering has emerged as a major discipline that bridges societal needs of human health care with the development of novel technologies. Every medical institution is now equipped at varying degrees of sophistica
Externí odkaz:
https://doaj.org/article/99aa19c8944b4368939a87375caa3abd
Autor:
Vaishali Sethi, Dana Cohen-Gerassi, Sagi Meir, Max Ney, Yulia Shmidov, Gil Koren, Lihi Adler-Abramovich, Ashutosh Chilkoti, Roy Beck
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract The cornerstone of structural biology is the unique relationship between protein sequence and the 3D structure at equilibrium. Although intrinsically disordered proteins (IDPs) do not fold into a specific 3D structure, breaking this paradigm
Externí odkaz:
https://doaj.org/article/91af896904ff40ecaeae6c03321f199d
Autor:
Lyra B. Olson, Nicole I. Hunter, Rachel E. Rempel, Haixiang Yu, Diane M. Spencer, Cynthia Z. Sullenger, William S. Greene, Anastasia K. Varanko, Seyed A. Eghtesadi, Ashutosh Chilkoti, David S. Pisetsky, Jeffrey I. Everitt, Bruce A. Sullenger
Publikováno v:
iScience, Vol 25, Iss 12, Pp 105542- (2022)
Summary: Nucleic acid-binding polymers can have anti-inflammatory properties and beneficial effects in animal models of infection, trauma, cancer, and autoimmunity. PAMAM G3, a polyamidoamine dendrimer, is fully cationic bearing 32 protonable surface
Externí odkaz:
https://doaj.org/article/c47c0949e0684823b161722dd21838e4
Autor:
Daniel Y. Joh, Jacob T. Heggestad, Shengwei Zhang, Grace R. Anderson, Jayanta Bhattacharyya, Suzanne E. Wardell, Simone A. Wall, Amy B. Cheng, Faris Albarghouthi, Jason Liu, Sachi Oshima, Angus M. Hucknall, Terry Hyslop, Allison H. S. Hall, Kris C. Wood, E. Shelley Hwang, Kyle C. Strickland, Qingshan Wei, Ashutosh Chilkoti
Publikováno v:
npj Breast Cancer, Vol 7, Iss 1, Pp 1-14 (2021)
Abstract Management of breast cancer in limited-resource settings is hindered by a lack of low-cost, logistically sustainable approaches toward molecular and cellular diagnostic pathology services that are needed to guide therapy. To address these li
Externí odkaz:
https://doaj.org/article/dbe9959994e64aa882ef7c71873c21a5
Autor:
Imran Ozer, Garrett Kelly, Renpeng Gu, Xinghai Li, Nikita Zakharov, Parul Sirohi, Smita K. Nair, Joel H. Collier, Michael S. Hershfield, Angus M. Hucknall, Ashutosh Chilkoti
Publikováno v:
Advanced Science, Vol 9, Iss 11, Pp n/a-n/a (2022)
Abstract Protein therapeutics, except for antibodies, have a short plasma half‐life and poor stability in circulation. Covalent coupling of polyethylene glycol (PEG) to protein drugs addresses this limitation. However, unlike previously thought, PE
Externí odkaz:
https://doaj.org/article/25fd6625ae81428db034482f847d8104
Autor:
Stefan Roberts, Vincent Miao, Simone Costa, Joseph Simon, Garrett Kelly, Tejank Shah, Stefan Zauscher, Ashutosh Chilkoti
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
The production of microparticles with complex geometries for biotechnological use historically requires sophisticated fabrication techniques. Here, the authors create complex particle geometries by exploiting the metastable region of the phase diagra
Externí odkaz:
https://doaj.org/article/b27ff72f4d4845dd828a86e498db9d9b
Autor:
Lione Willems, Stefan Roberts, Isaac Weitzhandler, Ashutosh Chilkoti, Enrico Mastrobattista, John van der Oost, Renko de Vries
Publikováno v:
ACS Omega, Vol 4, Iss 5, Pp 9135-9143 (2019)
Externí odkaz:
https://doaj.org/article/e8864204f8544e25b2d634dd31b719b5
Publikováno v:
APL Materials, Vol 9, Iss 2, Pp 021119-021119-13 (2021)
Many naturally occurring elastomers are intrinsically disordered proteins (IDPs) built up of repeating units, and they can demonstrate two types of thermoresponsive phase behavior. Systems characterized by lower critical solution temperatures (LCSTs)
Externí odkaz:
https://doaj.org/article/c657d67dbca348dcb56a5c9da7c08d21