Výsledky vyhledávání - "and Arlene E. McKeown"

Development of a Multikilogram Scale Synthesis of a TRPV1 Antagonist

Autor: Michel Journet, Zhihui Peng, Dalian Zhao, Arlene E. Mckeown, Guy R. Humphrey, Jeffrey T. Kuethe

Publikováno v: Organic Process Research & Development. 20:227-232

A highly efficient, regioselective five-step synthesis of the TRPV1 antagonist 1 is described. The coupling of piperazine 7 with dichloropyrimidine 8 proceeded via a regioselective Pd-mediated amination affording product 11 in excellent yield. Conver

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9ff56dfdcc1dda616fbcb2bfe14089a9
https://doi.org/10.1021/acs.oprd.5b00388

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Development of a Scaleable Synthesis of a Partial Nicotinic Acid Receptor Agonist

Autor: Robert D. Wilson, George Zhou, Antony J. Davies, Gavin W. Stewart, Karel M. J. Brands, David Hands, Steven F. Oliver, Michael S. Ashwood, Robert A. Reamer, Ed Cleator, Matthew M. Bio, Ulf-H. Dolling, Khateeta M. Emerson, Faye J. Sheen, Arlene E. Mckeown, Andrew D. Gibb

Publikováno v: Organic Process Research & Development. 13:543-547

A practical and efficient synthesis of 1,4,5,6-tetrahydro-3-(1H-tetrazol-5-yl)cyclopenta[c]pyrazole, 1, is described. A new one-pot process has been developed, starting from the commercially availa...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::189b5b874e3f609e10aad2d368739b31
https://doi.org/10.1021/op800290t

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On the Mechanism of an Asymmetric α,β-Unsaturated Carboxylic Acid Hydrogenation: Application to the Synthesis of a PGD2 Receptor Antagonist

Autor: Hinksmon J, Arlene E. Mckeown, McWilliams Jc, Michel Journet, Y.-K. Sun, Tillyer Rd, David M. Tellers, Guy R. Humphrey, Lisa DiMichele, Thorsten Rosner

Publikováno v: Journal of the American Chemical Society. 128:17063-17073

Ruthenium complexes employing axially chiral ligands were found to be effective asymmetric hydrogenation catalysts for the reduction of alpha,beta-unsaturated ene acid 1-E to give 2, a prostaglandin D2 (PGD2) receptor antagonist. With [(S-BINAP)Ru(p-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ccceaf159e7f0b93f80e31f09808832
https://doi.org/10.1021/ja0623358

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Stereoselective Formation of Carbon−Carbon Bonds via SN2-Displacement: Synthesis of Substituted Cycloalkyl[b]indoles

Autor: Richard D. Tillyer, Jean-François Marcoux, and Arlene E. McKeown, Dalian Zhao, Edward J. J. Grabowski, Michael C. Hillier

Publikováno v: The Journal of Organic Chemistry. 70:8385-8394

A general asymmetric synthesis of substituted cycloalkyl[b]indoles has been accomplished. The key features of this approach are (1) the utilization of a Japp-Klingemann condensation/Fischer cyclization to prepare cycloalkyl[b]indolones, (2) the asymm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::669580a38790abc14246394af15f7786
https://doi.org/10.1021/jo051146p

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Synthesis of zirconocene amides and ketimides and an investigation into their ethylene polymerization activity

Autor: Alan R. Kennedy, Kenneth W. Henderson, Amanda Hind, Arlene E. McKeown, Robert E. Mulvey

Publikováno v: Journal of Organometallic Chemistry. 656:63-70

The zirconocene amide [Cp2Zr(Cl)N(CH2Ph)(2)] (5), and the zirconbcene ketimides [Cp2Zr(Cl)N=C(Bu')Ph] (7), and [Cp2Zr(Cl)N=C(NMe2)(2)] (9), have been prepared by the transmetallation reactions between the appropriate lithiated organonitrogen compound

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::984e2e55ca773edb95ca575c2f47a0cf
https://doi.org/10.1016/s0022-328x(02)01559-0

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Zirconocene Ketimides: Synthesis, Structural Characterization, Ethylene Polymerization Activity, and ab Initio Computational Studies

Autor: and Arlene E. McKeown, Charles Jenny, Alan R. Kennedy, David R. Armstrong, Robert E. Mulvey, Kenneth W. Henderson, Ian Little

Publikováno v: Organometallics. 19:4369-4375

The metathetical reaction between the lithium 1-azaallyl compound [{HMPA·LiN(H)C(t-Bu)CH2}2] (1) with zirconocene dichloride (2) results in the formation of the zirconocene ketimide [Cp2Zr(Cl)N=C(t-Bu)CH3] (3; Cp = cyclopentadienyl) and lithium chlo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9a75dab222a75bf4ba9c22167590461d
https://doi.org/10.1021/om000451s

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Dimethylaluminium enolates and alkoxides derived from trimethylaluminium and aromatic ketones: a synthetic, structural and theoretical investigation

Autor: Kenneth W. Henderson, Mark R. J. Elsegood, John F. Allan, Igor M. Rakov, Paul H. Moran, William Clegg, Arlene E. McKeown

Publikováno v: Journal of Organometallic Chemistry. 602:15-23

Reaction of Me3Al with a series of aromatic ketones results in the precipitation of either dimethylaluminium enolates or alkoxides. In situ 1H-NMR spectroscopic studies of the reaction between Me3Al and acetophenone reveal a complex mixture of produc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3b9c3e58eab0c0dacf2c227a1c86f7d3
https://doi.org/10.1016/s0022-328x(00)00111-x

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Lithiated α-cyanophosphonates: self-assembly of two-dimensional molecular sheets composed of interconnected twenty-four membered rings †

Autor: Diane Strachan, Alan R. Kennedy, Kenneth W. Henderson, Arlene E. McKeown

Publikováno v: Journal of the Chemical Society, Dalton Transactions. :4348-4353

Reaction of the phosphonates (RO)2P(O)CH2CN (R = Et I or PriII) with one molar equivalent of LiNPri2 in THF gave the metallated complexes [(RO)2P(O)CHCNLi·THF]∞ (R = Et 1 or Pri2). Crystallographic analyses of them reveal that they form dimeric Li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9c66411b8970358dad7e62febf316208
https://doi.org/10.1039/b007038f

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