Zobrazeno 1 - 4
of 4
pro vyhledávání: '"and Anne L. Killam Bonneville"'
Autor:
Xin-Jun Liu, Yinghong Gao, Zhiqiang Guo, Martin W. Rowbottom, Timothy D. Gross, Anne L Killam Bonneville, Acevedo O, Caroline W. Chen, Struthers Rs, Haig Bozigian, Greg J. Reinhart, Ta-Kung Chen, Fabio C. Tucci, Nicholas Ling, John Saunders, Qui Xie, Yun-Fei Zhu
Publikováno v:
Journal of Medicinal Chemistry. 48:1169-1178
Further structure-activity relationship studies of a series of substituted uracils at the 1, 3, and 5 positions resulted in the discovery of several potent antagonists of the human gonadotropin-releasing hormone receptor. Uracils bearing a side chain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87529259eebd56ca0c42b5b5375da127
https://doi.org/10.1021/jm049218c
https://doi.org/10.1021/jm049218c
Autor:
Patrick J. Connors, Liping Jin, Haig Bozigian, Timothy D. Gross, Fabio C. Tucci, Ta Kung Chen, R. Scott Struthers, Chen Chen, Greg J. Reinhart, John Saunders, Qiu Xie, Martin W. Rowbottom, Yinghong Gao, Zhiqiang Guo, Anne L Killam Bonneville, Andrew Fisher, Yun-Fei Zhu
Publikováno v:
Journal of Medicinal Chemistry. 47:3483-3486
Uracils possessing N-3 side chains derived from various amino alcohols were designed and synthesized as potent human gonadotropin releasing hormone receptor antagonists. The compounds herein presented displayed superior metabolic stability than their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05a763114ebf99451c3177008485abea
https://doi.org/10.1021/jm049791w
https://doi.org/10.1021/jm049791w
Autor:
Greg J. Reinhart, Ta-Kung Chen, Trudy A. Kohout, R. Scott Struthers, Haig Bozigian, Anne L Killam Bonneville, Chen Chen, Qui Xie, Susan K. Sullivan, Weidong Yang, Yun-Fei Zhu, Xin-Jun Liu, Nicholas Ling, Richard A. Maki
Publikováno v:
Endocrinology. 148(2)
Suppression of the hypothalamic-pituitary-gonadal axis by peptides that act at the GnRH receptor has found widespread use in clinical practice for the management of sex-steroid-dependent diseases (such as prostate cancer and endometriosis) and reprod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12695b92817331b283ba628d8cd202b6
https://pubmed.ncbi.nlm.nih.gov/17095587
https://pubmed.ncbi.nlm.nih.gov/17095587
Autor:
Patrick J. Connors, Greg J. Reinhart, Ta Kung Chen, Yinghong Gao, Chen Chen, Fabio C. Tucci, Yongsheng Chen, Zhiqiang Guo, and Anne L. Killam Bonneville, John Saunders, Qiu Xie, Yun-Fei Zhu, R. Scott Struthers, Manisha Moorjani, Timothy D. Gross, Martin W. Rowbottom
Publikováno v:
Journal of medicinal chemistry. 47(5)
Based on the SAR from bicyclic gonadotropin-releasing hormone (GnRH) antagonists such as 6-aminomethyl-7-aryl-pyrrolo[1,2-a]pyrimid-4-ones (5) and 2-aryl-3-aminomethyl-imidazolo[1,2-a]pyrimid-5-ones (6a,b), a series of novel uracil compounds (8) were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7e3ad1f0157cc8d81d313b17dfd4357
https://pubmed.ncbi.nlm.nih.gov/14971906
https://pubmed.ncbi.nlm.nih.gov/14971906