Zobrazeno 1 - 10
of 40
pro vyhledávání: '"and Andrew S. Judd"'
Autor:
Junichiro Yuda, Christine Will, Darren C. Phillips, Linu Abraham, Cory Alvey, Abraham Avigdor, Wayne Buck, Lauren Besenhofer, Erwin Boghaert, Dong Cheng, Dan Cojocari, Kelly Doyle, T. Matthew Hansen, Kevin Huang, Eric F. Johnson, Andrew S. Judd, Russell A. Judge, John C. Kalvass, Aaron Kunzer, Lloyd T. Lam, Rachel Li, Ruth L. Martin, Anthony Mastracchio, Mike Mitten, Adam Petrich, Jin Wang, James E. Ward, Haichao Zhang, Xilu Wang, Johannes E. Wolff, Katherine M. Bell-McGuinn, Andrew J. Souers
Publikováno v:
Communications Medicine, Vol 3, Iss 1, Pp 1-14 (2023)
Abstract Background MCL-1 is a prosurvival B-cell lymphoma 2 family protein that plays a critical role in tumor maintenance and survival and can act as a resistance factor to multiple anticancer therapies. Herein, we describe the generation and chara
Externí odkaz:
https://doaj.org/article/a09a2953c50e4da8ad9915dfa149ffac
Publikováno v:
ACS Medicinal Chemistry Letters.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c97d01a030a9f99226e1502caaa31780
https://doi.org/10.1021/acsmedchemlett.3c00114
https://doi.org/10.1021/acsmedchemlett.3c00114
Autor:
Justin P Ingram, Russell A. Judge, Chang Park, Xilu Wang, Li Zhou, Sha Jin, Peter Kovar, Chaohong Sun, Andrew J. Souers, Steven W. Elmore, Haichao Zhang, Brian D. Wakefield, Joel D. Leverson, Jun Chen, Zhi-Fu Tao, Darren C. Phillips, Andrew S. Judd
Publikováno v:
ACS Medicinal Chemistry Letters. 12:1011-1016
BCL-XL, an antiapoptotic member of the BCL-2 family of proteins, drives tumor survival and maintenance and thus represents a key target for cancer treatment. Herein we report the rational design of a novel series of selective BCL-XL inhibitors exempl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f14863a3a8ba9a79583bbc0aee69f1b
https://doi.org/10.1021/acsmedchemlett.1c00162
https://doi.org/10.1021/acsmedchemlett.1c00162
Autor:
Paul Nimmer, Erwin R. Boghaert, Robin R. Frey, Phuong N Le, Andrew J. Souers, Peter Kovar, Wenqing Gao, Deepak Sampath, Dolores Diaz, Haichao Zhang, T. Matthew Hansen, Michael J. Mitten, Stephen K. Tahir, Russell A. Judge, Edna F. Choo, Yu Xiao, Shashank Shekhar, Xiaohong Song, George Doherty, Zhi-Fu Tao, Andrew S. Judd, Wayne J. Fairbrother, Michael D. Wendt, Steven W. Elmore, Kunzer Aaron R, Le Wang, Xilu Wang, Darren C. Phillips, Morey L. Smith, John A. Flygare, John Xue, Joel D. Leverson, Milan Bruncko, Chang H. Park, Nathaniel D. Catron
Publikováno v:
ACS Medicinal Chemistry Letters
Herein we describe the discovery of A-1331852, a first-in-class orally active BCL-XL inhibitor that selectively and potently induces apoptosis in BCL-XL-dependent tumor cells. This molecule was generated by re-engineering our previously reported BCL-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85af09593f6d81ea66757099b5fec23d
http://europepmc.org/articles/PMC7549103
http://europepmc.org/articles/PMC7549103
Autor:
Zhi-Fu, Tao, Xilu, Wang, Jun, Chen, Justin P, Ingram, Sha, Jin, Russell A, Judge, Peter J, Kovar, Chang, Park, Chaohong, Sun, Brian D, Wakefield, Li, Zhou, Haichao, Zhang, Steven W, Elmore, Darren C, Phillips, Andrew S, Judd, Joel D, Leverson, Andrew J, Souers
Publikováno v:
ACS Med Chem Lett
[Image: see text] BCL-X(L), an antiapoptotic member of the BCL-2 family of proteins, drives tumor survival and maintenance and thus represents a key target for cancer treatment. Herein we report the rational design of a novel series of selective BCL-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::026635ea19063286ee2f173e9e8a7a57
https://pubmed.ncbi.nlm.nih.gov/34141086
https://pubmed.ncbi.nlm.nih.gov/34141086
Autor:
Seble Wagaw, Andrew S. Judd, Jianzhang Mei, Kenneth M. Engstrom, Andrew J. Souers, Gang Zhao, Brian J. Kotecki, Philip R. Kym, Matthew M. Ravn
Publikováno v:
Organic Process Research & Development. 14:417-424
A synthesis of a selective diacyl glycerolacyltransferase-1 (DGAT-1) inhibitor, 1, is described. The synthesis illustrates a diketone Favorskii reaction on 9 in place of the more common ketoester variant for generation of the dicarboxycyclopentane co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dde9159c7cd78e997230e4074fbe58d4
https://doi.org/10.1021/op900310v
https://doi.org/10.1021/op900310v
Publikováno v:
Expert Opinion on Therapeutic Patents. 20:19-29
Postprandial hypertriglyceridemia has been identified as a major independent risk factor for future cardiovascular events. Therefore, inhibition of triglyceride synthesis has enormous therapeutic potential in the treatment of metabolic disorders. Dia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58609267dfced6e1ae0a15e3d9cb7a8d
https://doi.org/10.1517/13543770903499305
https://doi.org/10.1517/13543770903499305
Publikováno v:
Current Topics in Medicinal Chemistry. 8:1152-1157
The discovery of small molecule melanin concentrating hormone receptor (MHCr1) antagonists as novel therapeutic agents has been widely pursued across the pharmaceutical industry. While multiple chemotypes of small molecule MCHr1 antagonists have been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c553bb9c792c90c3480c41c4aeb16916
https://doi.org/10.2174/156802608785700052
https://doi.org/10.2174/156802608785700052
Autor:
Andrew S. Judd, Tsuneaki Hida, Philippe Breton, Stephen F. Martin, Philip R. Kym, Masayuki Yamashita, Erica Kraynack, Paul J. Hergenrother, W.‐C. Lee, Michael S. Loft, Anne V. Hodgson
Publikováno v:
Tetrahedron. 63:5709-5729
We report the details of the first total synthesis of erythromycin B using two different strategies for the end game. The first of these follows a classical approach in which the desosamine and cladinose residues are sequentially appended to a macroc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0182a626edc3b18b6a226b76392dcf25
https://doi.org/10.1016/j.tet.2007.02.044
https://doi.org/10.1016/j.tet.2007.02.044
Autor:
Gilbert Diaz, Lee C. Preusser, Ann Mikhail, Christopher A. Ogiela, Lynch John K, Philip R. Kym, Lisa M. Hernández, Dariusz Wodka, Gang Zhao, Doug H. Falls, Eugene N. Bush, James S. Polakowski, Andrew S. Judd, Robin Shapiro, Hing L. Sham, James J. Napier, Christine A. Collins, Kennan C. Marsh, Victoria Knourek-Segel, Glenn A. Reinhart, Thomas J Campbell, Sevan Brodjian, Michael E. Brune, Brian A. Droz, Mathew M. Mulhern, Kathryn Houseman, Regina M. Reilly, Brian D. Dayton, Ryan M. Fryer, James T. Limberis, Rajesh R. Iyengar, Freeman Jennifer C
Publikováno v:
Journal of Medicinal Chemistry. 49:6569-6584
Evaluation of multiple structurally distinct series of melanin concentrating hormone receptor 1 antagonists in an anesthetized rat cardiovascualar assay led to the identification of a chromone-2-carboxamide series as having excellent safety against t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b667ab564d57ac2f27112dd9382a72ab
https://doi.org/10.1021/jm060683e
https://doi.org/10.1021/jm060683e