Zobrazeno 1 - 10 of 859 pro vyhledávání: '"and Andrew D. Hamilton"'
1
Akademický článek
Protein mimetic amyloid inhibitor potently abrogates cancer-associated mutant p53 aggregation and restores tumor suppressor function
Autor: L. Palanikumar, Laura Karpauskaite, Mohamed Al-Sayegh, Ibrahim Chehade, Maheen Alam, Sarah Hassan, Debabrata Maity, Liaqat Ali, Mona Kalmouni, Yamanappa Hunashal, Jemil Ahmed, Tatiana Houhou, Shake Karapetyan, Zackary Falls, Ram Samudrala, Renu Pasricha, Gennaro Esposito, Ahmed J. Afzal, Andrew D. Hamilton, Sunil Kumar, Mazin Magzoub
Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-24 (2021)
Amyloid aggregation of mutant p53 contributes to its loss of tumor suppressor function and oncogenic gain-of-function. Here, the authors use a protein mimetic to abrogate mutant p53 aggregation and rescue p53 function, which inhibits cancer cell prol
Externí odkaz: https://doaj.org/article/aabfbc8d47544f739652c54bd2eb3f1f
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2
Akademický článek
Designed Cell-Penetrating Peptide Inhibitors of Amyloid-beta Aggregation and Cytotoxicity
Autor: Anja Henning-Knechtel, Sunil Kumar, Cecilia Wallin, Sylwia Król, Sebastian K.T.S. Wärmländer, Jüri Jarvet, Gennaro Esposito, Serdal Kirmizialtin, Astrid Gräslund, Andrew D. Hamilton, Mazin Magzoub
Publikováno v: Cell Reports Physical Science, Vol 1, Iss 2, Pp 100014- (2020)
Summary: Amyloid proteins and peptides are a major contributing factor to the development of various neurodegenerative disorders, including Alzheimer’s and prion diseases. Previously, a designed cell-penetrating peptide (CPP) comprising a hydrophob
Externí odkaz: https://doaj.org/article/5d236af9e01344af9941d4946465ac90
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4
Data from Combination of Farnesyltransferase and Akt Inhibitors Is Synergistic in Breast Cancer Cells and Causes Significant Breast Tumor Regression in ErbB2 Transgenic Mice
Autor: Saïd M. Sebti, Jin Q. Cheng, Andrew D. Hamilton, Domenico Coppola, William J. Fulp, Y. Ann Chen, Kara D. Forinash, Maria E. Balasis
The Akt activation inhibitor triciribine and the farnesyltransferase inhibitor tipifarnib have modest to little activity in clinical trials when used as single agents. In this article, preclinical data show that the combination is more effective than
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e0895cd4b3d0ea341e7f26ac360ffdb
https://doi.org/10.1158/1078-0432.c.6519345
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6
Akademický článek
Redox-Dependent Conformational Switching of Diphenylacetylenes
Autor: Ian M. Jones, Peter C. Knipe, Thoe Michaelos, Sam Thompson, Andrew D. Hamilton
Publikováno v: Molecules, Vol 19, Iss 8, Pp 11316-11332 (2014)
Herein we describe the design and synthesis of a redox-dependent single-molecule switch. Appending a ferrocene unit to a diphenylacetylene scaffold gives a redox-sensitive handle, which undergoes reversible one-electron oxidation, as demonstrated by
Externí odkaz: https://doaj.org/article/848dcffc5a534ed78552bb2299b7f17b
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7
Protein mimetic amyloid inhibitor potently abrogates cancer-associated mutant p53 aggregation and restores tumor suppressor function
Autor: Laura Karpauskaite, Ahmed J. Afzal, Ibrahim Chehade, Jemil Ahmed, Renu Pasricha, Mazin Magzoub, Andrew D. Hamilton, Debabrata Maity, Mona Kalmouni, Loganathan Palanikumar, Sunil Kumar, Maheen Alam, Tatiana Houhou, Gennaro Esposito, Zackary Falls, Shake Karapetyan, Yamanappa Hunashal, Ram Samudrala, Mohamed Al-Sayegh, Liaqat Ali, Sarah Hassan
Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-24 (2021)
Nature Communications
Missense mutations in p53 are severely deleterious and occur in over 50% of all human cancers. The majority of these mutations are located in the inherently unstable DNA-binding domain (DBD), many of which destabilize the domain further and expose it
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::914b9d23167b4db0a4609f8d776a3030
https://doaj.org/article/aabfbc8d47544f739652c54bd2eb3f1f
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8
Peptidomimetic-Based Vesicles Inhibit Amyloid-β Fibrillation and Attenuate Cytotoxicity
Autor: Debabrata Maity, Andrew D. Hamilton, Maria C. Vogel, Madeline Howarth, Mazin Magzoub
Publikováno v: Journal of the American Chemical Society. 143:3086-3093
An interruption in Aβ homeostasis leads to the deposit of neurotoxic amyloid plaques and is associated with Alzheimer's disease. A supramolecular strategy based on the assembly of peptidomimetic agents into functional vesicles has been conceived for
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25470b3393919729ac09e7232c1499a6
https://doi.org/10.1021/jacs.0c09967
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10
Cucurbit[7]uril Inhibits Islet Amyloid Polypeptide Aggregation by Targeting N Terminus Hot Segments and Attenuates Cytotoxicity
Autor: Debabrata Maity, Yujeong Oh, Lothar Gremer, Wolfgang Hoyer, Mazin Magzoub, Andrew D. Hamilton
Publikováno v: Chemistry-a European journal 28(38), na/na (2022). doi:10.1002/chem.202201698
Two "hot segments" within an islet amyloid polypeptide are responsible for its self-assembly, which in turn is linked to the decline of β-cells in type 2 diabetes (T2D). A readily available water-soluble, macrocyclic host, cucurbit[7]uril (CB[7]), e
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f8d315c227f2c715e2db62251e4eacd
https://doi.org/10.1002/chem.202200456
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