Zobrazeno 1 - 10
of 16
pro vyhledávání: '"and Amy J. Pfizenmayer"'
Publikováno v:
The Journal of Organic Chemistry. 66:7575-7587
The design and synthesis of two conformationally constrained analogues of didemnin B are described. The [N,O-Me(2)Tyr(5)]residue of didemnin B was replaced with L-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (Tic) and L-1,2,3,4-tetrahydro-7-metho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::129ce66ed88b2b9e36672650bee0ff29
https://doi.org/10.1021/jo0105991
https://doi.org/10.1021/jo0105991
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:13-16
The synthesis and biological activity of N e -Z-[Lys 3 ]didemnin B are reported. This novel analogue retains antiproliferative, cytotoxic, and protein biosynthesis inhibition activities, but at reduced levels. This result suggests the use of [Lys 3 ]
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca8f4f359131f8be6bd62279d8aabc70
https://doi.org/10.1016/s0960-894x(00)00585-0
https://doi.org/10.1016/s0960-894x(00)00585-0
Autor:
Joshi M. Ramanjulu, Matthew D. Vera, Chen Wei-Chuan, Madeleine M. Joullié, Dong Xiao, Xiaobin Ding, Amy J. Pfizenmayer
Publikováno v:
Tetrahedron. 55:313-334
Based on information from X-ray, NMR, and SAR data, the N , O -diMeTyr 5 unit of didemnin B was believed to be important for biological activity. To determine the importance of aromaticity and the role of the methoxy group in this unit, two analogs w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32671c81355db90debf9f240e9310b8f
https://doi.org/10.1016/s0040-4020(98)01042-4
https://doi.org/10.1016/s0040-4020(98)01042-4
Autor:
Matthew D. Vera, Deepika Tandon, Amy J. Pfizenmayer, Wei-Chuan Chen, Peter L. Toogood, Madeleine M. Joullié, Xiaobin Ding, Dong Xiao
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 8:3653-3656
A didemnin B analog containing a Tic (1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid) as a conformationally restrained replacement for tyrosine has been synthesized and shown to have comparable potency as a protein biosynthesis inhibitor. Synthetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5af2a939ab6cc268e876977e05068bc4
https://doi.org/10.1016/s0960-894x(98)00662-3
https://doi.org/10.1016/s0960-894x(98)00662-3
Publikováno v:
Tetrahedron: Asymmetry. 8:3043-3046
β-Hydroxy-λ-amino acids are a class of non-proteinogenic amino acids present in many important biologically active natural products. In conjunction with our research on didemnins, we designed and synthesized a sterically constrained β-hydroxy-λ-a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53122c9ecc30bdef333db1fb43f301be
https://doi.org/10.1016/s0957-4166(97)00402-3
https://doi.org/10.1016/s0957-4166(97)00402-3
Publikováno v:
Tetrahedron: Asymmetry. 5:519-522
An asymmetric Diels-Alder reaction in the presence of 3.0 M lithium perchlorate-diethyl ether was used to generate the initial stereochemistry for a cyclohexane amino acid (3), a key intermediate in the preparation of a fused ring didemnin analog. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f7eccd14d9a75716d4441658bc31e54
https://doi.org/10.1016/0957-4166(94)80007-3
https://doi.org/10.1016/0957-4166(94)80007-3
Publikováno v:
ChemInform. 25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::833de53e96b2ae29e692e9b36ab51252
https://doi.org/10.1002/chin.199434267
https://doi.org/10.1002/chin.199434267
Publikováno v:
ChemInform. 26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8e1db7ac5d8f3f98485c7053aca31de
https://doi.org/10.1002/chin.199510261
https://doi.org/10.1002/chin.199510261
Publikováno v:
ChemInform. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::401940eaad61ccfa60188407e6cfba2d
https://doi.org/10.1002/chin.199629202
https://doi.org/10.1002/chin.199629202
Autor:
Dong Xiao, Xiaobin Ding, Amy J. Pfizenmayer, Madeleine M. Joullié, Matthew D. Vera, Wei-Chuan Chen
Publikováno v:
ChemInform. 30
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc0b9e65169bb80233308ac15854db4d
https://doi.org/10.1002/chin.199917205
https://doi.org/10.1002/chin.199917205