Zobrazeno 1 - 10
of 334
pro vyhledávání: '"and Amy Hauck Newman"'
Autor:
Sandra Arroyo-Urea, Antonina L. Nazarova, Ángela Carrión-Antolí, Alessandro Bonifazi, Francisco O. Battiti, Jordy Homing Lam, Amy Hauck Newman, Vsevolod Katritch, Javier García-Nafría
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Although aminergic GPCRs are the target for ~25% of approved drugs, developing subtype selective drugs is a major challenge due to the high sequence conservation at their orthosteric binding site. Bitopic ligands are covalently joined orthos
Externí odkaz:
https://doaj.org/article/0f4e0633b3e3419cba2085acebcdab61
Autor:
Gisela Andrea Camacho-Hernandez, Adithya Gopinath, Amarachi V. Okorom, Habibeh Khoshbouei, Amy Hauck Newman
Publikováno v:
JACS Au, Vol 4, Iss 2, Pp 657-665 (2024)
Externí odkaz:
https://doaj.org/article/c2940d5ba86146768d5b45c0a6bb528c
Publikováno v:
Biomolecules, Vol 14, Iss 6, p 713 (2024)
Modafinil analogs with either a sulfoxide or sulfide moiety have improved binding affinities at the human dopamine transporter (hDAT) compared to modafinil, with lead sulfoxide-substituted analogs showing characteristics of atypical inhibition (e.g.,
Externí odkaz:
https://doaj.org/article/395b108d5c4d41e3abc6a00c9797e9a9
Autor:
Jacqueline D. Keighron, Jordi Bonaventura, Yang Li, Jae-Won Yang, Emily M. DeMarco, Melinda Hersey, Jianjing Cao, Walter Sandtner, Michael Michaelides, Harald H. Sitte, Amy Hauck Newman, Gianluigi Tanda
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Typical and atypical dopamine uptake inhibitors (DUIs) prefer distinct conformations of the dopamine transporter (DAT) to form ligand-transporter complexes, resulting in markedly different effects on behavior, neurochemistry, and potential f
Externí odkaz:
https://doaj.org/article/b76b51eca73a4f0bb45544c468f3d7ee
Autor:
Francesca Longhena, Gaia Faustini, Andrea Casiraghi, Valentina Straniero, Giovanni Ribaudo, Veronica Mutti, Gisela Camacho-Hernandez, Cristina Missale, Amy Hauck Newman, Federica Bono, Alessandra Gianoncelli, Ermanno Valoti, Arianna Bellucci
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp S441- (2023)
Externí odkaz:
https://doaj.org/article/ce7db29105e04cacbd1d0f0fa62e7f2b
Autor:
Dino Luethi, Julian Maier, Deborah Rudin, Dániel Szöllősi, Thomas J. F. Angenoorth, Stevan Stankovic, Matthias Schittmayer, Isabella Burger, Jae-Won Yang, Kathrin Jaentsch, Marion Holy, Anand Kant Das, Mario Brameshuber, Gisela Andrea Camacho-Hernandez, Andrea Casiraghi, Amy Hauck Newman, Oliver Kudlacek, Ruth Birner-Gruenberger, Thomas Stockner, Gerhard J. Schütz, Harald H. Sitte
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-11 (2022)
Phosphatidylinositol 4,5-bisphosphate (PIP2) directly regulates norepinephrine transporter (NET) dimer stabilization at the plasma membrane. Furthermore, PIP2 interaction with NET affects efflux.
Externí odkaz:
https://doaj.org/article/bf06230a2bde4a6abd1164301e9e14ad
Autor:
Alishan S. Amirali, Jacquelin C. Hecker, Hector L. Figueroa-Monsanto, Devin P. Effinger, Rodrigo A. Montoro, Hank P. Jedema, Caleb D. Vogt, Amy Hauck Newman, Charles W. Schindler, Charles W. Bradberry
Publikováno v:
Addiction Neuroscience, Vol 5, Iss , Pp 100065- (2023)
We recently reported an economic choice task in which squirrel monkeys chose between differing amounts of remifentanil, a fast-acting opioid, or a food reward to develop a preclinical screen for evaluating potential pharmacotherapies for opioid depen
Externí odkaz:
https://doaj.org/article/92e06a43f74b4b2d96ba6e7f0ef970c3
Publikováno v:
Molecules, Vol 28, Iss 13, p 5270 (2023)
Psychostimulant use disorders (PSUD) affect a growing number of men and women and exert sizable public health and economic burdens on our global society. Notably, there are some sex differences in the onset of dependence, relapse rates, and treatment
Externí odkaz:
https://doaj.org/article/941a5b6f385941d7a250ac950ff44c56
Autor:
Andrea Casiraghi, Francesca Longhena, Gaia Faustini, Giovanni Ribaudo, Lorenzo Suigo, Gisela Andrea Camacho-Hernandez, Federica Bono, Viviana Brembati, Amy Hauck Newman, Alessandra Gianoncelli, Valentina Straniero, Arianna Bellucci, Ermanno Valoti
Publikováno v:
Pharmaceutics, Vol 14, Iss 8, p 1595 (2022)
Parkinson’s disease (PD) is characterized by dopaminergic nigrostriatal neurons degeneration and Lewy body pathology, mainly composed of α-synuclein (αSyn) fibrillary aggregates. We recently described that the neuronal phosphoprotein Synapsin III
Externí odkaz:
https://doaj.org/article/7770818800974b4aa72847a66f038d82
Publikováno v:
Current topics in behavioral neurosciences.
Over three decades of evidence indicate that dopamine (DA) D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a2cf72f1a3de189e750e378984978084
https://pubmed.ncbi.nlm.nih.gov/35543868
https://pubmed.ncbi.nlm.nih.gov/35543868