Zobrazeno 1 - 10
of 36
pro vyhledávání: '"and Alphonse Galdes"'
Autor:
Alphonse Galdes, Darren P. Baker, Elisabeth Traiffort, Olivier Pascual, Jean Champagnat, Martial Ruat
Publikováno v:
European Journal of Neuroscience. 22:389-396
The transmembrane receptor Patched (Ptc) mediates the action of the diffusing factor Sonic hedgehog (Shh), which is implicated in establishing morphogenetic gradients during embryonic development. Whereas alteration of Ptc function is associated with
Autor:
Ellen Garber, Alphonse Galdes, Dingyi Wen, Xiaoping Hronowski, Melissa Levesque, Kathryn L. Strauch, Alan Gill, Frederick R. Taylor, Renee I. Shapiro
Publikováno v:
Protein Expression and Purification. 29:272-283
We have investigated the suitability of Pichia pastoris as an expression system for the candidate therapeutic protein, Sonic hedgehog fused to an immunoglobulin Fc domain (Shh-Fc). Sonic hedgehog is a morphogen protein involved in the patterning of a
Autor:
David R. Tomlinson, Jean Dominique Delcroix, Renee I. Shapiro, Rigel Ranciato, Jason D. Freshwater, Frederick R. Taylor, Monica L. Burgers, Andrew P. Mizisin, Thomas Engber, Nigel A. Calcutt, Henryk Dudek, Alicia Middlemas, Alphonse Galdes, Karen L. Allendoerfer, Lee L. Rubin, Kathy Strauch
Publikováno v:
Journal of Clinical Investigation. 111:507-514
Hedgehog proteins modulate development and patterning of the embryonic nervous system. As expression of desert hedgehog and the hedgehog receptor, patched-1, persist in the postnatal and adult peripheral nerves, the hedgehog pathway may have a role i
Autor:
Alphonse Galdes, Philippe Hantraye, Jean-Michel Hermel, Martial Ruat, Elisabeth Traiffort, Dorota Charytoniuk
Publikováno v:
European Journal of Neuroscience. 16:2351-2357
The morphogen sonic hedgehog (Shh) is implicated in neural tissue patterning and the growth of brain structures during embryogenesis and postnatal development and is also present in the adult brain. Shh signals through interaction with the tumour sup
Autor:
Malcolm Gains, Susan Y. Smith, James D. Green, Louise Pouliot, Pauline L. Martin, Rudolph Stejskal, Joan Lane, Alphonse Galdes
Publikováno v:
Drug Development Research. 57:107-114
Sonic hedgehog (Shh) is a member of a family of proteins that are involved in embryonic development. The receptor signaling pathways for Shh persist in adults and stimulation of this pathway has shown therapeutic efficacy in animal models of neurodeg
Autor:
Adrian Whitty, Ellen Garber, Frederick R. Taylor, Paul H. Weinreb, Darren P. Baker, Amie N. Carmillo, Kevin P. Williams, Dingyi Wen, Ann Boriack-Sjodin, Paul Rayhorn, Xiaoping Hronowski, Eric S. Day, Renee I. Shapiro, Robert M. Arduini, R. Blake Pepinsky, and Alphonse Galdes
Publikováno v:
Biochemistry. 40:4359-4371
Post-translational modifications of the developmental signaling protein Sonic hedgehog (Shh) by a long-chain fatty acid at the N-terminus and cholesterol at the C-terminus greatly activate the protein in a cell-based signaling assay. To investigate t
Publikováno v:
Journal of Chromatography A. 559:391-399
Motilin is a gut hormone, which is involved in gastrointestinal motility. Capillary electrophoresis studies were made on 24 peptides that are N-terminal, C-terminal or internal fragments of motilin. The isoelectric point, total charge and hydrophobic
Autor:
Bert L. Vallee, Alphonse Galdes
Publikováno v:
Advances in Enzymology and Related Areas of Molecular Biology, Volume 56
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6910e1e11797c81d1dcbaac12aa3d59a
https://doi.org/10.1002/9780470123027.ch5
https://doi.org/10.1002/9780470123027.ch5
Autor:
Olivier, Pascual, Elisabeth, Traiffort, Darren P, Baker, Alphonse, Galdes, Martial, Ruat, Jean, Champagnat
Publikováno v:
The European journal of neuroscience. 22(2)
The transmembrane receptor Patched (Ptc) mediates the action of the diffusing factor Sonic hedgehog (Shh), which is implicated in establishing morphogenetic gradients during embryonic development. Whereas alteration of Ptc function is associated with
Autor:
Paul Rayhorn, Alphonse Galdes, Dingyi Wen, Thomas Engber, Doreen Lepage, Renee I. Shapiro, Shaoshan Wang, R. Blake Pepinsky, Frederick R. Taylor, Ellen Garber, Gerald S.B. Horan, Abhijit Chakraborty, Alan Gill
Publikováno v:
Journal of pharmaceutical sciences. 91(2)
The therapeutic effects of the Sonic hedgehog (Shh) have been difficult to evaluate because of its relatively short serum half-life. To address this issue polyethylene glycol modification (PEGylation) was investigated as an approach to improve system