Zobrazeno 1 - 10
of 38
pro vyhledávání: '"and Alexander G. Yakovlev"'
Autor:
Ke Ren, Edwin M. Meyer, Italo Mocchetti, Rachel L. Nosheny, Alexander G. Yakovlev, Farid Ahmed, Lino Tessarollo
Publikováno v:
European Journal of Neuroscience. 25:2275-2284
Glycoprotein 120 (gp120) from the T-tropic strain of the human immunodeficiency virus type 1 has been shown to cause neuronal apoptosis through activation of the chemokine receptor CXCR4. Therefore, reducing CXCR4 expression may prevent gp120-mediate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53685bee443027f0cdfd4ace3c75394a
https://doi.org/10.1111/j.1460-9568.2007.05506.x
https://doi.org/10.1111/j.1460-9568.2007.05506.x
Autor:
Alan I. Faden, Mahadev Rao, Jeannette Beers, Jason Catania, Alexander G. Yakovlev, Chad D. Knights, Maria Laura Avantaggiati, Simone Di Giovanni
Publikováno v:
The EMBO Journal. 25:4084-4096
Axon regeneration is substantially regulated by gene expression and cytoskeleton remodeling. Here we show that the tumor suppressor protein p53 is required for neurite outgrowth in cultured cells including primary neurons as well as for axonal regene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cdbcfe53d648636fee80d769172a5d8
https://doi.org/10.1038/sj.emboj.7601292
https://doi.org/10.1038/sj.emboj.7601292
Publikováno v:
Journal of Medicinal Chemistry. 47:6455-6458
In this paper we report the synthesis and characterization of a novel potent and selective inhibitor of caspase-3, a member of the caspase family of cysteine proteases which plays an important role in many human disorders. This molecule represents 3(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::968f629edf32e0ed7ec70cc69ac8e110
https://doi.org/10.1021/jm049248f
https://doi.org/10.1021/jm049248f
Autor:
Wenfan Liu, Bogdan A. Stoica, Geping Wang, Simone Di Giovanni, Alexander G. Yakovlev, Alan I. Faden
Publikováno v:
Journal of Biological Chemistry. 279:28367-28374
Cellular stress leads to DNA damage and activation of the intrinsic apoptotic pathway in which translocation of mitochondrial cytochrome c to the cytosol plays a critical role. Previous studies have suggested alternative mechanisms responsible for th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7fb789bebc77d105c9311645ee54127
https://doi.org/10.1074/jbc.m313526200
https://doi.org/10.1074/jbc.m313526200
Publikováno v:
Journal of Biological Chemistry. 277:8273-8278
Caspase-3 is the major effector in apoptosis triggered by various stimuli. Previous studies demonstrated a significant increase in transcriptional activity of the caspase-3 gene during neuronal apoptosis. Recent findings suggest that differential exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9a17fc5150e4a3b57d996894da90032
https://doi.org/10.1074/jbc.m110768200
https://doi.org/10.1074/jbc.m110768200
Autor:
Asako Itaya, Yasuharu Tanaka, Katsuya Ota, Koichiro Yoshihara, Masanori Kameoka, Alexander G. Yakovlev
Publikováno v:
Journal of Biochemistry. 131:131-135
Brain and liver extracts of rats at different stages after birth were examined for cytochrome c/dATP-dependent caspase (DEVDase)-activation (mitochondria pathway) in vitro. The caspase-activating activity in the brain extracts rapidly decreased after
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92f6d579f34ff250b711963adbe273fb
https://doi.org/10.1093/oxfordjournals.jbchem.a003067
https://doi.org/10.1093/oxfordjournals.jbchem.a003067
Autor:
Mark E. Smulson, A. Hamid Boulares, Alexander G. Yakovlev, Koichiro Yoshihara, Anna J. Zoltoski, Francisco J. Contreras
Publikováno v:
Journal of Biological Chemistry. 277:372-378
Several endonucleases are implicated in the internucleosomal DNA fragmentation associated with apoptosis. The human Ca2+- and Mg2+-dependent endonuclease DNAS1L3 is inhibited by poly(ADP-ribosyl)ation in vitro, and its activation during apoptosis sho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8068bc1542e9828a04283115ff1e3118
https://doi.org/10.1074/jbc.m107738200
https://doi.org/10.1074/jbc.m107738200
Publikováno v:
Biochemical and Biophysical Research Communications. 290:796-801
DNA fragmentation factor (DFF) comprises DFF45 and DFF40 subunits, the former of which acts as an inhibitor of the latter (the catalytic subunit) and whose cleavage by caspase-3 results in DFF activation. Disruption of the DFF45 gene blocks the gener
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44d10e5cb271fa9bff280e0bdf2decbe
https://doi.org/10.1006/bbrc.2001.6280
https://doi.org/10.1006/bbrc.2001.6280
Publikováno v:
Journal of Biological Chemistry. 276:38185-38192
During apoptosis, endonucleases cleave DNA into 50-300-kb fragments and subsequently into internucleosomal fragments. DNA fragmentation factor (DFF) is implicated in apoptotic DNA cleavage; this factor comprises DFF45 and DFF40 subunits, the former o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d525a1c7c97dea09af7168d94956a2d
https://doi.org/10.1074/jbc.m100629200
https://doi.org/10.1074/jbc.m100629200
Autor:
Koichiro Yoshihara, Alan I. Faden, Geping Wang, Katsuya Ota, Alexander G. Yakovlev, Vilen A. Movsesyan, Wei-Li Bao
Publikováno v:
The Journal of Neuroscience. 21:7439-7446
Neuronal apoptosis plays an essential role in early brain development and contributes to secondary neuronal loss after acute brain injury. Recent studies have provided evidence that neuronal susceptibility to apoptosis induced by traumatic or ischemi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5214275e79584dfa2d938e1b84e8246
https://doi.org/10.1523/jneurosci.21-19-07439.2001
https://doi.org/10.1523/jneurosci.21-19-07439.2001