Zobrazeno 1 - 10
of 594
pro vyhledávání: '"and Alexander D. MacKerell"'
Publikováno v:
ACS Omega, Vol 9, Iss 38, Pp 40154-40171 (2024)
Externí odkaz:
https://doaj.org/article/591db5761fb543b29d43c3b0141fdbd2
Autor:
Rodrigo Lázaro‐Gorines, Patricia Pérez, Ignacio Heras‐Murillo, Irene Adán‐Barrientos, Guillermo Albericio, David Astorgano, Sara Flores, Joanna Luczkowiak, Nuria Labiod, Seandean L. Harwood, Alejandro Segura‐Tudela, Laura Rubio‐Pérez, Yudhi Nugraha, Xiaoran Shang, Yuxing Li, Carlos Alfonso, Kaylin A. Adipietro, Dinendra L. Abeyawardhane, Rocío Navarro, Marta Compte, Wenbo Yu, Alexander D. MacKerell Jr, Laura Sanz, David J. Weber, Francisco J. Blanco, Mariano Esteban, Edwin Pozharski, Raquel Godoy‐Ruiz, Inés G. Muñoz, Rafael Delgado, David Sancho, Juan García‐Arriaza, Luis Álvarez‐Vallina
Publikováno v:
Advanced Science, Vol 10, Iss 34, Pp n/a-n/a (2023)
Abstract Administration of neutralizing antibodies (nAbs) has proved to be effective by providing immediate protection against SARS‐CoV‐2. However, dual strategies combining virus neutralization and immune response stimulation to enhance specific
Externí odkaz:
https://doaj.org/article/83ee823ecfc342e88a1c1efafa321622
Autor:
Keith M. Olson, Andrea L. Devereaux, Payal Chatterjee, Savanah L. Saldaña-Shumaker, Amanda Shafer, Adam Plotkin, Ram Kandasamy, Alexander D. MacKerell, John R. Traynor, Christopher W. Cunningham
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Introduction: There is a major societal need for analgesics with less tolerance, dependence, and abuse liability. Preclinical rodent studies suggest that bifunctional ligands with both mu (MOPr) and delta (DOPr) opioid peptide receptor activity may p
Externí odkaz:
https://doaj.org/article/d66de2654cdc423f8f571b1ac7860458
Publikováno v:
Chemistry, Vol 4, Iss 3, Pp 630-646 (2022)
The human ether-a-go-go-related gene (hERG) potassium channel is a well-known contributor to drug-induced cardiotoxicity and therefore is an extremely important target when performing safety assessments of drug candidates. Ligand-based approaches in
Externí odkaz:
https://doaj.org/article/b4da44b444bb4915870fd72b30c63809
Autor:
Orna Ernst, Mohd M. Khan, Benjamin L. Oyler, Sung Hwan Yoon, Jing Sun, Fang-Yu Lin, Nathan P. Manes, Alexander D. MacKerell, Iain D. C. Fraser, Robert K. Ernst, David R. Goodlett, Aleksandra Nita-Lazar
Publikováno v:
mSystems, Vol 6, Iss 4 (2021)
Macrophages and monocytes are innate immune cells playing an important role in orchestrating the initial innate immune response to bacterial infection and the tissue damage. This response is facilitated by specific receptors on the cell surface and i
Externí odkaz:
https://doaj.org/article/1f3c6a2170e74a2e812d8133d72e914a
Autor:
Asaminew H Aytenfisu, Daniel Deredge, Erik H Klontz, Jonathan Du, Eric J Sundberg, Alexander D MacKerell
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 7, p e1009103 (2021)
Antibodies bind foreign antigens with high affinity and specificity leading to their neutralization and/or clearance by the immune system. The conserved N-glycan on IgG has significant impact on antibody effector function, with the endoglycosidases o
Externí odkaz:
https://doaj.org/article/1c5a1fb3a1a0497cac4852104caef0b6
Publikováno v:
Journal of Chemical Theory and Computation. 19:3007-3021
Autor:
Yalun Yu, Richard M. Venable, Jonathan Thirman, Payal Chatterjee, Anmol Kumar, Richard W. Pastor, Benoît Roux, Alexander D. MacKerell, Jeffery B. Klauda
Publikováno v:
Journal of Chemical Theory and Computation. 19:2590-2605
Publikováno v:
Molecular Pharmaceutics. 20:2600-2611
Autor:
Sharanbasappa S. Karade, Evelyn J. Franco, Ana C. Rojas, Kaley C. Hanrahan, Alexander Kolesnikov, Wenbo Yu, Alexander D. MacKerell, Daniel C. Hill, David J. Weber, Ashley N. Brown, Anthony M. Treston, Roy A. Mariuzza
Publikováno v:
Journal of Medicinal Chemistry. 66:2744-2760