Zobrazeno 1 - 10
of 16
pro vyhledávání: '"and Alex V. Trevino"'
Autor:
Misty M. Strain, Sirima Tongkhuya, Nathan Wienandt, Farah Alsadoon, Roger Chavez, Jamar Daniels, Thomas Garza, Alex V. Trevino, Kenney Wells, Thomas Stark, John Clifford, Natasha M. Sosanya
Publikováno v:
BMC Neuroscience, Vol 23, Iss 1, Pp 1-14 (2022)
Abstract In the military, constant physiological and psychological stress encountered by Soldiers can lead to development of the combat and operational stress reaction (COSR), which can effect pain management. Similar effects are seen in other popula
Externí odkaz:
https://doaj.org/article/cc081f3c7fc94c4eb1af11a3dbd46ebc
Autor:
Misty M. Strain, Sirima Tongkhuya, Nathan Wienandt, Farah Alsadoon, Roger Chavez, Jamar Daniels, Thomas Garza, Alex V. Trevino, Kenney Wells, Thomas Stark, John Clifford, Natasha M. Sosanya
Publikováno v:
BMC neuroscience. 23(1)
In the military, constant physiological and psychological stress encountered by Soldiers can lead to development of the combat and operational stress reaction (COSR), which can effect pain management. Similar effects are seen in other populations sub
Autor:
Alex V. Trevino, Barbara A. Woynarowska, Terence S. Herman, Waldemar Priebe, Jan M. Woynarowski
Publikováno v:
Molecular Cancer Therapeutics. 3:1403-1410
Targeting topoisomerase II (topo II) is regarded as an important component of the pleiotropic mechanism of action of anthracycline drugs. Here, we show that 4-demethoxy analogues of doxorubicin, including annamycin, exhibit a greater ability to trap
Autor:
Stephen J. Waters, John R. MacDonald, Alex V. Trevino, Jan M. Woynarowski, Richard A. Salinas, Terence S. Herman, Barbara A. Woynarowska
Publikováno v:
Cancer Biology & Therapy. 3:1137-1142
Unlike postmitotic cell death, direct premitotic apoptosis diminishes the risk of clonal selection and allows for the elimination of slowly growing cancer cells. This study characterized the ability to induce premitotic apoptosis by irofulven (hydrox
Autor:
Jan M. Woynarowski, Jennifer A. Jackson, Terence S. Herman, Alex V. Trevino, Maryanne C. Herzig
Publikováno v:
Nucleic Acids Research. 31:6354-6364
AT-rich minisatellites (AT islands) are sites of genomic instability in cancer cells and targets for extremely lethal AT-specific drugs, such as bizelesin. Here we investigated the AT islands in the FRA16B fragile site region for their possible roles
Publikováno v:
Journal of Biological Chemistry. 276:40555-40566
Interstrand cross-links at T(A/T)4A sites in cellular DNA are associated with hypercytotoxicity of an anticancer drug, bizelesin. Here we evaluated whether these lethal effects reflect targeting critical genomic regions. An in silico analysis of huma
Autor:
Eric Raymond, Alex V. Trevino, Alexandra Vaisman, Stephen G. Chaney, Sandrine Faivre, Paul E. Juniewicz, Maryanne C. Herzig, William G. Chapman, Jan M. Woynarowski, Brenda Arnett, Maria Varchenko
Publikováno v:
Molecular Pharmacology. 58:920-927
Damage to cellular DNA is believed to determine the antiproliferative properties of platinum (Pt) drugs. This study characterized DNA damage by oxaliplatin, a diaminocyclohexane Pt drug with clinical antitumor activity. Compared with cisplatin, oxali
Publikováno v:
Biochemistry. 39:9917-9927
Bizelesin and adozelesin are DNA-reactive antitumor drugs that alkylate adenines at the 3' ends of their preferred binding sites [5'T(A/T)(4)A3'and 5'(A/T)(3)(-4)A3', respectively]. We used these drugs to examine the determinants for region-specific
Autor:
Michael Dale Lairmore, Gary P. Toedter, Lawrence E. Mathes, Garret C. Newbound, Julie G. Ericson, Alex V. Trevino
Publikováno v:
Cytometry. 18:49-54
Whole blood lysis and fixation methods for flow cytometric (FCM) analysis were tested for their ability to reduce the infectivity of human T-lymphotropic virus type 1 (HTLV-I). Our goals were to: (1) determine the effects of 1.0 and 2.0% paraformalde
Autor:
Stephen J. Waters, John R. MacDonald, Alex V. Trevino, Jan M. Woynarowski, Barbara A. Woynarowska, Richard A. Salinas, Huiyun Liang, Maryanne C. Herzig
Publikováno v:
Biochemical pharmacology. 65(4)
The overexpression of Bcl-2 is implicated in the resistance of cancer cells to apoptosis. This study explored the potential of irofulven (hydroxymethylacylfulvene, HMAF, MGI 114, NSC 683863), a novel DNA- and protein-reactive anticancer drug, to over