Zobrazeno 1 - 7
of 7
pro vyhledávání: '"and Alex V. Sokoloff"'
Publikováno v:
Molecular Immunology. 45:1501-1513
Natural IgM antibodies (Abs) play an important role in clearing pathogens, enhancing immune responses, and preventing autoimmunity. However, the molecular mechanisms that mediate the functions of natural IgM Abs are understood only to a limited degre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07fef2d753a8a94bb1ee01b8c03449ba
https://doi.org/10.1016/j.molimm.2007.07.043
https://doi.org/10.1016/j.molimm.2007.07.043
Autor:
Jason Klein, Darren H. Wakefield, and Alex V. Sokoloff, Sean D. Monahan, Jon A. Wolff, David B. Rozema, Lori Higgs, James J. Ludtke, David L. Lewis, So C. Wong
Publikováno v:
Molecular Pharmaceutics. 3:386-397
A critical step for liver-directed gene therapy is the selective targeting of nucleic acids to hepatocytes. We have previously discovered that the proximal half of the T7 phage tail fiber protein (p17) targeted intact T7 phage and recombinant protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98eda459ef51a3ee01e2580ebf63745a
https://doi.org/10.1021/mp050108r
https://doi.org/10.1021/mp050108r
Publikováno v:
Immunology. 112:237-249
Both the timely clearance of degraded endogenous structures and the presence of secreted natural immunoglobulin M (IgM) are needed to avoid autoimmunity. These requirements may be causally related provided that natural IgM preferentially reacts with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7087459d9fe0527bfcc0114d767b1663
https://doi.org/10.1111/j.1365-2567.2004.01868.x
https://doi.org/10.1111/j.1365-2567.2004.01868.x
Autor:
Guofeng Zhang, Vladimir M. Subbotin, Tatyana Budker, Jon A. Wolff, Magdolna G. Sebestyén, Yoshihiro Sumita, Alex V. Sokoloff, Marcus A. Bachhuber, James J. Ludtke, So C. Wong
Publikováno v:
Molecular Therapy. 8(6):867-872
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::473f4c5375fbc134f94c77e7150aceb3
Specific Recognition of Protein Carboxy-Terminal Sequences by Natural IgM Antibodies in Normal Serum
Autor:
Anne M. Cooke, Sara Hoffman, Ildiko Bock, Guofeng Zhang, James Dama, James J. Ludtke, Alex V. Sokoloff, Jon A. Wolff
Publikováno v:
Molecular Therapy. 3:821-830
Our previous study indicated that normal serum contains complement-fixing natural IgM antibodies reacting with a large variety of randomly generated protein carboxy-termini. Here we show that the "carboxy-terminal" IgM (C-IgM) antibodies specifically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fb88bbe64775a47e739fbb9cf44cde1
https://doi.org/10.1006/mthe.2001.0340
https://doi.org/10.1006/mthe.2001.0340
Peptide-mediated targeting of hepatocytes via low density lipoprotein receptor-related protein (LRP)
Autor:
Dudley K. Strickland, Guofeng Zhang, So Wong, Jon A. Wolff, Alex V. Sokoloff, James J. Ludtke
Publikováno v:
Drug delivery. 16(5)
It has previously been reported that a peptide sequence of T7 phage protein p17 mediates uptake of its cargo by liver parenchymal cells. The aim of this study was to identify the phage-binding receptor. The involvement of LRP was confirmed by the obs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::059618fa16f2b79d008d50537608d0c0
https://pubmed.ncbi.nlm.nih.gov/19538008
https://pubmed.ncbi.nlm.nih.gov/19538008
Publikováno v:
Molecular therapy : the journal of the American Society of Gene Therapy. 2(2)
The icosahedral T7 phage (diameter approximately 65 nm) displaying random peptides at the carboxy-terminus of the phage coat proteins was used as a model for drug and gene delivery vehicles containing peptide ligands. We found that displayed peptides
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4768decca31a5ec0ac76a9dca27b6312
https://pubmed.ncbi.nlm.nih.gov/10947936
https://pubmed.ncbi.nlm.nih.gov/10947936