Zobrazeno 1 - 9
of 9
pro vyhledávání: '"and Alex V. Sokoloff"'
Publikováno v:
Molecular Immunology. 45:1501-1513
Natural IgM antibodies (Abs) play an important role in clearing pathogens, enhancing immune responses, and preventing autoimmunity. However, the molecular mechanisms that mediate the functions of natural IgM Abs are understood only to a limited degre
Autor:
Jason Klein, Darren H. Wakefield, and Alex V. Sokoloff, Sean D. Monahan, Jon A. Wolff, David B. Rozema, Lori Higgs, James J. Ludtke, David L. Lewis, So C. Wong
Publikováno v:
Molecular Pharmaceutics. 3:386-397
A critical step for liver-directed gene therapy is the selective targeting of nucleic acids to hepatocytes. We have previously discovered that the proximal half of the T7 phage tail fiber protein (p17) targeted intact T7 phage and recombinant protein
Publikováno v:
Immunology. 112:237-249
Both the timely clearance of degraded endogenous structures and the presence of secreted natural immunoglobulin M (IgM) are needed to avoid autoimmunity. These requirements may be causally related provided that natural IgM preferentially reacts with
Autor:
Guofeng Zhang, Vladimir M. Subbotin, Tatyana Budker, Jon A. Wolff, Magdolna G. Sebestyén, Yoshihiro Sumita, Alex V. Sokoloff, Marcus A. Bachhuber, James J. Ludtke, So C. Wong
Publikováno v:
Molecular Therapy. 8(6):867-872
Specific Recognition of Protein Carboxy-Terminal Sequences by Natural IgM Antibodies in Normal Serum
Autor:
Anne M. Cooke, Sara Hoffman, Ildiko Bock, Guofeng Zhang, James Dama, James J. Ludtke, Alex V. Sokoloff, Jon A. Wolff
Publikováno v:
Molecular Therapy. 3:821-830
Our previous study indicated that normal serum contains complement-fixing natural IgM antibodies reacting with a large variety of randomly generated protein carboxy-termini. Here we show that the "carboxy-terminal" IgM (C-IgM) antibodies specifically
Peptide-mediated targeting of hepatocytes via low density lipoprotein receptor-related protein (LRP)
Autor:
Dudley K. Strickland, Guofeng Zhang, So Wong, Jon A. Wolff, Alex V. Sokoloff, James J. Ludtke
Publikováno v:
Drug delivery. 16(5)
It has previously been reported that a peptide sequence of T7 phage protein p17 mediates uptake of its cargo by liver parenchymal cells. The aim of this study was to identify the phage-binding receptor. The involvement of LRP was confirmed by the obs
Publikováno v:
Molecular therapy : the journal of the American Society of Gene Therapy. 2(2)
The icosahedral T7 phage (diameter approximately 65 nm) displaying random peptides at the carboxy-terminus of the phage coat proteins was used as a model for drug and gene delivery vehicles containing peptide ligands. We found that displayed peptides
Autor:
Ludtke, James J.1 (AUTHOR), Sokoloff, Alex V.1 (AUTHOR), Wong, So2 (AUTHOR), Zhang, Guofeng1 (AUTHOR), Strickland, Dudley K.3 (AUTHOR), Wolff, Jon A.1 (AUTHOR) jwolff@wisc.edu
Publikováno v:
Drug Delivery. Jul2009, Vol. 16 Issue 5, p268-273. 6p. 3 Graphs.
Autor:
Sokoloff, Alex V.1,2 sokoloff@wisc.edu, Puckett, Marissa1,2, Ludtke, James J.1,2, Fetterly, Bryan1,2
Publikováno v:
Immunology. Jun2004, Vol. 112 Issue 2, p237-249. 13p.