Zobrazeno 1 - 10
of 35
pro vyhledávání: '"and Alecia K. Gross"'
Autor:
Roly Megaw, Abigail Moye, Zhixian Zhang, Fay Newton, Fraser McPhie, Laura C. Murphy, Lisa McKie, Feng He, Melissa K. Jungnickel, Alex von Kriegsheim, Peter A. Tennant, Chloe Brotherton, Christine Gurniak, Alecia K. Gross, Laura M. Machesky, Theodore G. Wensel, Pleasantine Mill
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract As signalling organelles, cilia regulate their G protein-coupled receptor content by ectocytosis, a process requiring localised actin dynamics to alter membrane shape. Photoreceptor outer segments comprise an expanse of folded membranes (dis
Externí odkaz:
https://doaj.org/article/162f25833a9b438992ccafbff79b3556
Publikováno v:
Frontiers in Ophthalmology, Vol 2 (2022)
The maintenance of intraocular pressure (IOP) is critical to preserving the pristine optics required for vision. Disturbances in IOP can directly impact the optic nerve and retina, and inner retinal injury can occur following acute and chronic IOP el
Externí odkaz:
https://doaj.org/article/5a84dd9cc19e4bff91ede5c12bafac92
Autor:
T.J. Hollingsworth, Meredith G. Hubbard, Hailey J. Levi, William White, Xiangdi Wang, Raven Simpson, Monica M. Jablonski, Alecia K. Gross
Publikováno v:
Biomolecules, Vol 11, Iss 8, p 1163 (2021)
Retinitis pigmentosa (RP) is a hereditary disease of the retina that results in complete blindness. Currently, there are very few treatments for the disease and those that exist work only for the recessively inherited forms. To better understand the
Externí odkaz:
https://doaj.org/article/51222d457ee84673bc4a2aceedf7499d
Autor:
T.J. Hollingsworth, Alecia K. Gross
Publikováno v:
Cells, Vol 9, Iss 3, p 630 (2020)
Inherited retinal dystrophies (RDs) are heterogenous in many aspects including genes involved, age of onset, rate of progression, and treatments. While RDs are caused by a plethora of different mutations, all result in the same outcome of blindness.
Externí odkaz:
https://doaj.org/article/380a9f6648ca40378229aa6e90201405
Autor:
Christopher A. Girkin, Mary Anne Garner, Massimo A. Fazio, Mark E. Clark, Udayakumar Karuppanan, Meredith G. Hubbard, Gianfranco Bianco, Seth T. Hubbard, Brad Fortune, Alecia K. Gross
Publikováno v:
Experimental Eye Research. 229:109420
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e922829d6ab61dbdba735c9bc2afdab9
https://doi.org/10.1016/j.exer.2023.109420
https://doi.org/10.1016/j.exer.2023.109420
Autor:
Anil K Challa, Evan R Boitet, Ashley N Turner, Larry W Johnson, Daniel Kennedy, Ethan R Downs, Katherine M Hymel, Alecia K Gross, Robert A Kesterson
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0155812 (2016)
Tyrosinase is a key enzyme in melanin biosynthesis. Mutations in the gene encoding tyrosinase (Tyr) cause oculocutaneous albinism (OCA1) in humans. Alleles of the Tyr gene have been useful in studying pigment biology and coat color formation. Over 10
Externí odkaz:
https://doaj.org/article/95612f7154c0442c904d4ddc71281093
Publikováno v:
International Journal of Molecular Sciences. 23:8068
Glaucomatous optic neuropathy is the leading cause of irreversible blindness in the world. The chronic disease is characterized by optic nerve degeneration and vision field loss. The reduction of intraocular pressure remains the only proven glaucoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::012846cfb777dc6857394f063ae3b798
https://doi.org/10.3390/ijms23158068
https://doi.org/10.3390/ijms23158068
Autor:
Ivette M Sandoval, Brandee A Price, Alecia K Gross, Fung Chan, Joshua D Sammons, John H Wilson, Theodore G Wensel
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e108135 (2014)
For sensitive detection of rare gene repair events in terminally differentiated photoreceptors, we generated a knockin mouse model by replacing one mouse rhodopsin allele with a form of the human rhodopsin gene that causes a severe, early-onset form
Externí odkaz:
https://doaj.org/article/16baeec528b947bb922a3c037c30319e
Autor:
Melissa R. Bentley, Katie L. Bales, Bradley K. Yoder, Mandy J. Croyle, Robert A. Kesterson, Alecia K. Gross
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose To identify the role of the BBSome protein Bardet-Biedl syndrome 5 (BBS5) in photoreceptor function, protein trafficking, and structure using a congenital mutant mouse model. Methods Bbs5-/- mice (2 and 9 months old) were used to assess retin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b69c6cd97047b84877c1117519ab0d6a
https://pubmed.ncbi.nlm.nih.gov/32776140
https://pubmed.ncbi.nlm.nih.gov/32776140
Autor:
Alecia K. Gross, TJ Hollingsworth
Publikováno v:
Cells
Volume 9
Issue 3
Cells, Vol 9, Iss 3, p 630 (2020)
Volume 9
Issue 3
Cells, Vol 9, Iss 3, p 630 (2020)
Inherited retinal dystrophies (RDs) are heterogenous in many aspects including genes involved, age of onset, rate of progression, and treatments. While RDs are caused by a plethora of different mutations, all result in the same outcome of blindness.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7720901d7a8e6d8b3753dcf1855f737