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Autor:
Andrew Potter, Lisa M. Fisher, Nicolas Foloppe, Peter Kierstan, Allan E. Surgenor, Rob Howes, and Alan G. S. Robertson
Publikováno v:
Journal of Medicinal Chemistry. 48:4332-4345
We report the discovery, synthesis, and crystallographic binding mode of novel furanopyrimidine and pyrrolopyrimidine inhibitors of the Chk1 kinase, an oncology target. These inhibitors are synthetically tractable and inhibit Chk1 by competing for it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6be2c3ed8c638738546212adc758572
https://doi.org/10.1021/jm049022c
https://doi.org/10.1021/jm049022c
