Zobrazeno 1 - 10
of 35
pro vyhledávání: '"and Aktham Aburub"'
Autor:
Huyen, Tran, Phenil J, Patel, Aktham, Aburub, Andrea, Sperry, Selina, Estwick, Mohamed E H, ElSayed, Amita Datta, -Mannan
Publikováno v:
Pharmaceutical Research. 39:2555-2567
Oral delivery of therapeutic peptides has been challenging due to multiple physiological factors and physicochemical properties of peptides. We report a systematic approach to identify formulation compositions combining a permeation enhancer and a pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8faa1d5e6ef9a1dbe1752e282c72140
https://doi.org/10.1007/s11095-022-03372-1
https://doi.org/10.1007/s11095-022-03372-1
Publikováno v:
Pharmaceutical research. 39(9)
pH-dependent drug-drug interactions (DDIs) with poorly soluble, weakly basic drugs may lead to clinical implications. Dasatinib is a tyrosine kinase inhibitor with reduced absorption in patients on acid-reducing agents (ARAs). The objective of this s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7e0039d655d3399ea856b13989953c37
https://pubmed.ncbi.nlm.nih.gov/35778632
https://pubmed.ncbi.nlm.nih.gov/35778632
Autor:
Aktham, Aburub, Yuan, Chen, John, Chung, Ping, Gao, David, Good, Simone, Hansmann, Michael, Hawley, Tycho, Heimbach, Martin, Hingle, Filippos, Kesisoglou, Rong, Li, John, Rose, Christophe, Tisaert
Publikováno v:
The AAPS Journal. 24
Assessment of bioperformance to inform formulation selection and development decisions is an important aspect of drug development. There is high demand in the pharmaceutical industry to develop an efficient and streamlined approach for better underst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::427f38b1edebcd5c13ceb067e4d86ac7
https://doi.org/10.1208/s12248-022-00699-w
https://doi.org/10.1208/s12248-022-00699-w
Publikováno v:
Powder Technology. 342:856-863
Content uniformity (CU) is a well-recognized challenge for low-dose direct compression (DC) tablet formulations. Using a dual particle engineering approach that involves a) forming a segregation-resistant drug-carrier composite to improve CU and b) n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::347a2bbf2b830eda4c7053e40eaecd67
https://doi.org/10.1016/j.powtec.2018.10.054
https://doi.org/10.1016/j.powtec.2018.10.054
Publikováno v:
International Journal of Pharmaceutics. 544:158-164
Gastrointestinal luminal pH shows a rise from the duodenum to the terminal ileum in healthy individuals. Our objectives were to compare the pH in the proximal small intestine (SI) (first 60 min of small intestinal transit) lumen of human volunteers a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b40204da4990ef6d78c3c6d23c3d4eda
https://doi.org/10.1016/j.ijpharm.2018.04.031
https://doi.org/10.1016/j.ijpharm.2018.04.031
Autor:
Kevin C. White, Paul A. Stroud, Brian W. Pack, David C. Sperry, Mark Schrad, Yelizaveta Babayan, Aktham Aburub
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 142:307-314
The purpose of this work was to develop a meaningful in vitro dissolution method for evacetrapib spray-dried dispersion (SDD) tablets that is discriminating for crystalline drug substance (DS) content. Justification of the method conditions included
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fa7e32862c6925a551506505ca6f044
https://doi.org/10.1016/j.jpba.2017.05.029
https://doi.org/10.1016/j.jpba.2017.05.029
Autor:
Phenil J. Patel, Christopher Breslin, Michael Koenig, Aaron Zettler, Jon Hilden, Aktham Aburub, Allgeier Matthew Carl, Biplob Mitra
Publikováno v:
Journal of Pharmaceutical Innovation. 11:189-199
In pharmaceutical development, powder flow characteristics are notoriously difficult to predict. Although tests exist that aim to determine the flowability of powders, many have not been definitively correlated with a powder’s performance in downst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e0ccf02a2d2e9705af688c4cb9b0438
https://doi.org/10.1007/s12247-016-9258-5
https://doi.org/10.1007/s12247-016-9258-5
Publikováno v:
Journal of pharmaceutical sciences. 108(4)
Direct compression (DC) is the easiest and most cost-effective process for tablet manufacturing, because it only involves blending and compression. However, active pharmaceutical ingredients generally exhibit poor mechanical and micromeritic properti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0f662cb6a068816a400151882f5248d
https://pubmed.ncbi.nlm.nih.gov/30448523
https://pubmed.ncbi.nlm.nih.gov/30448523
Publikováno v:
Journal of pharmaceutical sciences. 108(1)
Nifedipine is a Biopharmaceutics Classification System class II drug displaying large variability in absorption even when administered as immediate-release soft gelatin capsules of a cosolvent formulation. This in vitro study sought to understand the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed8f4cf0777ca14deb334c0a984c5d90
https://pubmed.ncbi.nlm.nih.gov/30075162
https://pubmed.ncbi.nlm.nih.gov/30075162
Autor:
Shobha N. Bhattachar, Aktham Aburub, Xuan Ding, John P. Rose, David C. Sperry, Evelyn D. Lobo
Publikováno v:
Journal of pharmaceutical sciences. 108(1)
Relative bioavailability (RBA) studies are often carried out to bridge changes made between drug products used for clinical studies. In this work, we describe the development of a risk assessment (RA) tool that comprehensively and objectively assesse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::837ee82826af2ac28174704431303d4f
https://pubmed.ncbi.nlm.nih.gov/30053554
https://pubmed.ncbi.nlm.nih.gov/30053554