Zobrazeno 1 - 10
of 22
pro vyhledávání: '"and Akira Nagakura"'
Publikováno v:
Folia Pharmacologica Japonica. 136:15-20
Publikováno v:
Cardiovascular Research. 63:709-718
Objective: We have recently shown a decreased expression of Gia proteins and associated functions in aorta from short term (5 days) streptozotocin-induced diabetic rats. Since hyperglycemia is one of the underlying causes of diabetes-induced cardiova
Autor:
Tsuyoshi Ando, Tomoko Fukatsu, Akira Nagakura, Makiko Niimura, Kouichi Tanonaka, Keiko Miyake-Takagi, Norio Takagi, Satoshi Takeo
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 304:513-523
The present study was aimed at determining whether nefiracetam might have a persistent cognition-enhancing effect in animals with sustained cerebral ischemia. Sustained cerebral ischemia was induced by injecting 700 microspheres into the right intern
Autor:
Akira Nagakura, Keiko Miyake-Takagi, Tsuyoshi Ando, Norio Takagi, Tomoko Fukatsu, Kouichi Tanonaka, Junko Hara, Satoshi Takeo, Makiko Niimura
Publikováno v:
British Journal of Pharmacology. 138:642-654
Accumulated evidence indicates that the adenylyl cyclase (AC)/cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA)/cAMP-responsive element binding protein (CREB) signal transduction system may be linked to learning and memory function. The ef
Publikováno v:
British Journal of Pharmacology. 135:1783-1793
The effects of treatment with rolipram, a specific phosphodiesterase IV inhibitor, on learning and memory function and on the cyclic AMP/PKA/CREB signal transduction system were examined in rats with microsphere embolism (ME)-induced cerebral ischaem
Publikováno v:
Journal of Agricultural and Food Chemistry. 49:5013-5018
Four isomers of the L-aspartyl-D-alanine fenchyl esters were prepared as potential peptide sweeteners. L-Aspartyl-D-alanine (+)-alpha-fenchyl ester and L-aspartyl-D-alanine (-)-beta-fenchyl ester showed sweetness with potencies 250 and 160 times high
Publikováno v:
Flavour and Fragrance Journal. 11:327-332
Some L-aspartylnorbornylamino alcohol derivatives were synthesized as potential peptide sweeteners. Of these compounds, 3-(L-aspartylamino)-1-(3-methyl-2-norbornyl)-2-butanol displays an excellent sweetness potency. By further synthesis of one diaste
Publikováno v:
Journal of Essential Oil Research. 8:517-520
trans-2-Pinanol was directly rearranged to give α-fenchol in good yield by heating with aluminum phosphate as a solid acid catalyst.
Publikováno v:
European journal of pharmacology. 703(1-3)
Alzheimer's disease is characterized by a progressive decline in cognitive function and involves β-amyloid (Aβ) in its pathogenesis. To characterize cognitive deficits associated with Aβ accumulation, we analyzed PS1/APP mice overexpressing mutant
Publikováno v:
Tetrahedron Letters. 35:6891-6894
Four fenchylaminoalcohols were derived from ( + )-fenchone in five steps. They were resolved with ( + )- and (−)-tartaric acid, then condensed with N-carbobenzoxy-L-aspartic acid β-benzylester followed by hydrogenolysis to give four L-aspartyl-fen