Zobrazeno 1 - 10
of 1 274
pro vyhledávání: '"and Akira Hara"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Fibromyalgia is a heterogenous chronic pain disorder diagnosed by symptom-based criteria. The aim of this study was to clarify different pathophysiological characteristics between subgroups of patients with fibromyalgia. We identified subgro
Externí odkaz:
https://doaj.org/article/a2a94ad0f62e4edc9f3150b708992462
Autor:
Mikiko Matsuo, Ayumu Kanbe, Kei Noguchi, Ayumi Niwa, Yuko Imaizumi, Takahito Kuroda, Koki Ichihashi, Takafumi Okubo, Kosuke Mori, Tomohiro Kanayama, Hiroyuki Tomita, Akira Hara
Publikováno v:
PLoS ONE, Vol 19, Iss 2, p e0298284 (2024)
Galectin-3 is a beta-galactoside-binding lectin that plays important roles in diverse physiological functions, such as cell proliferation, apoptosis, and mRNA splicing. This protein is expressed on inflammatory cells and acts as a local inflammatory
Externí odkaz:
https://doaj.org/article/4e45ec6afecb48a9a920f908bd18b0dc
Autor:
Torai Enomoto, Hideshi Okada, Hiroyuki Tomita, Koji Iinuma, Keita Nakane, Yuki Tobisawa, Akira Hara, Takuya Koie
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2024)
Introduction: The abnormal glycocalyx (GCX) on the surface of cancer cells has been reported to be tall and aberrantly glycosylated and has been linked to the progression and spread of cancer—a finding also observed in bladder cancer. However, the
Externí odkaz:
https://doaj.org/article/ebf69c10eebd4fefb1f9179fcc13bf0d
Autor:
Azusa Haba, Yuko Imaizumi, Daichi Hayashi, Shiho Yasue, Hiroki Otsuka, Saori Endo, Michio Ozeki, Kazuhiro Kobayashi, Tatsuhiko Miyazaki, Akira Hara, Hidenori Ohnishi
Publikováno v:
Hematology, Vol 28, Iss 1 (2023)
ABSTRACTBackground Transient abnormal myelopoiesis (TAM) is characterized by leukocytosis with increased circulating megakaryoblasts that harbor N-terminal truncating mutations in the GATA1 gene. Approximately 10% of affected patients experience earl
Externí odkaz:
https://doaj.org/article/d41750bc1a3346248b64fb0dc059783b
Autor:
Yoshifumi Noda, Hiroyuki Tomita, Takuma Ishihara, Yoshiki Tsuboi, Nobuyuki Kawai, Masaya Kawaguchi, Tetsuro Kaga, Fuminori Hyodo, Akira Hara, Avinash R. Kambadakone, Masayuki Matsuo
Publikováno v:
BMC Medical Imaging, Vol 22, Iss 1, Pp 1-10 (2022)
Abstract Background To evaluate the utility of histogram analysis (HA) of apparent diffusion coefficient (ADC) values to predict the overall survival (OS) in patients with pancreatic ductal adenocarcinoma (PDAC) and to correlate with pathologically e
Externí odkaz:
https://doaj.org/article/c25b68f4d6c844c8983bbea804baa89b
Autor:
Takamasa Kinoshita, Hiroyuki Tomita, Hideshi Okada, Ayumi Niwa, Fuminori Hyodo, Tomohiro Kanayama, Mikiko Matsuo, Yuko Imaizumi, Takahiro Kuroda, Yuichiro Hatano, Masafumi Miyai, Yusuke Egashira, Yukiko Enomoto, Noriyuki Nakayama, Shigeyuki Sugie, Kazu Matsumoto, Yu Yamaguchi, Masayuki Matsuo, Hideaki Hara, Toru Iwama, Akira Hara
Publikováno v:
Discover Oncology, Vol 12, Iss 1, Pp 1-15 (2021)
Abstract Purpose Heparan sulfate (HS) is one of the factors that has been suggested to be associated with angiogenesis and invasion of glioblastoma (GBM), an aggressive and fast-growing brain tumor. However, it remains unclear how HS of endothelial c
Externí odkaz:
https://doaj.org/article/b5d26bf40ce2496e8e351218cdfaeb3c
Autor:
Ayumi Niwa, Toshiaki Taniguchi, Hiroyuki Tomita, Hideshi Okada, Takamasa Kinoshita, Chika Mizutani, Mikiko Matsuo, Yuko Imaizumi, Takahito Kuroda, Koki Ichihashi, Takaaki Sugiyama, Tomohiro Kanayama, Yu Yamaguchi, Shigeyuki Sugie, Nobuhisa Matsuhashi, Akira Hara
Publikováno v:
PLoS ONE, Vol 18, Iss 2, p e0281820 (2023)
Heparan sulfate (HS) is a glycocalyx component present in the extracellular matrix and cell-surface HS proteoglycans (HSPGs). Although HSPGs are known to play functional roles in multiple aspects of tumor development and progression, the effect of HS
Externí odkaz:
https://doaj.org/article/ebccd94bb7a84a52ba55a9aaf8c0c1c9
Autor:
Takeshi Sekiya, Yukino Ogura, Hirayasu Kai, Atsushi Kawaguchi, Shino Okawa, Mikako Hirohama, Takahiro Kuroki, Wataru Morii, Akira Hara, Yuji Hiramatsu, Shigemi Hitomi, Yasushi Kawakami, Yoshihiro Arakawa, Kazushi Maruo, Shigeru Chiba, Hiromichi Suzuki, Hiroshi Kojima, Hirokazu Tachikawa, Kunihiro Yamagata
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
COVID-19 has a wide range of clinical presentations, and the susceptibility to SARS-CoV-2 infection and the mortality rate also vary by region and ethnicity. Here, we found that rs12329760 in the TMPRSS2 gene, a missense variant common in East Asian
Externí odkaz:
https://doaj.org/article/c1b2e9b20dd745868ec02620a18a0c18
Publikováno v:
Biomedicines, Vol 11, Iss 10, p 2731 (2023)
Treating malignant glioma is challenging owing to its highly invasive potential in healthy brain tissue and the formation of intense surrounding edema. Peritumoral edema in gliomas can lead to severe symptoms including neurological dysfunction and br
Externí odkaz:
https://doaj.org/article/e52c3f857f1b46c586d57c62447fcdba
Autor:
Ryo Kamidani, Keisuke Kumada, Hideshi Okada, Genki Yoshimura, Tomohiro Kanayama, Hiroyuki Tomita, Tomotaka Miura, Hideaki Oiwa, Yosuke Mizuno, Yuichiro Kitagawa, Ryu Yasuda, Tetsuya Fukuta, Takahito Miyake, Tomoaki Doi, Takahiro Yoshida, Shozo Yoshida, Akira Hara, Shinji Ogura
Publikováno v:
International Journal of Emergency Medicine, Vol 14, Iss 1, Pp 1-6 (2021)
Abstract Background Pulmonary tumor thrombotic microangiopathy (PTTM) is a condition that involves the development of pulmonary hypertension due to the presence of microscopic tumor emboli of the peripheral pulmonary arteries. Here, we report a case
Externí odkaz:
https://doaj.org/article/6fe7e2dd89b043939ad7358d2e94302b