Zobrazeno 1 - 10
of 222
pro vyhledávání: '"and Adriano Martinelli"'
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 365-371 (2020)
The selectivity for a specific human Carbonic Anhydrase (hCA) isoform is an important property a hCA inhibitor (CAI) should be endowed with, in order to constitute a valuable therapeutic tool for the treatment of a desired pathology. In this context,
Externí odkaz:
https://doaj.org/article/3407e248215145478682005a4ced2a2c
Autor:
Gabriele Bassi, Nicholas Favalli, Miriam Vuk, Marco Catalano, Adriano Martinelli, Anika Trenner, Antonio Porro, Su Yang, Chuin Lean Tham, Mustafa Moroglu, Wyatt W. Yue, Stuart J. Conway, Peter K. Vogt, Alessandro A. Sartori, Jörg Scheuermann, Dario Neri
Publikováno v:
Advanced Science, Vol 7, Iss 22, Pp n/a-n/a (2020)
Abstract A versatile and Lipinski‐compliant DNA‐encoded library (DEL), comprising 366 600 glutamic acid derivatives coupled to oligonucleotides serving as amplifiable identification barcodes is designed, constructed, and characterized. The GB‐D
Externí odkaz:
https://doaj.org/article/6523af672d2b411ba7e7080f84e45492
Autor:
Carlotta Granchi, Isabella Caligiuri, Eleonora Bertelli, Giulio Poli, Flavio Rizzolio, Marco Macchia, Adriano Martinelli, Filippo Minutolo, Tiziano Tuccinardi
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 32, Iss 1, Pp 1240-1252 (2017)
Monoacylglycerol lipase is a serine hydrolase that plays a major role in the degradation of the endocannabinoid neurotransmitter 2-arachidonoylglycerol. A wide number of MAGL inhibitors are reported in literature; however, many of them are characteri
Externí odkaz:
https://doaj.org/article/6713ea22f79240ac81b20e055ca423c5
Autor:
Louise Plais, Alice Lessing, Michelle Keller, Adriano Martinelli, Sebastian Oehler, Gabriele Bassi, Dario Neri, Jörg Scheuermann
Publikováno v:
Chemical Science, 13 (4)
DNA-encoded chemical libraries (DELs) are useful tools for the discovery of small molecule ligands to protein targets of pharmaceutical interest. Compared with single-pharmacophore DELs, dual-pharmacophore DELs simultaneously display two chemical moi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4373d116b261f59e9d4cbd7e4a9d0a71
https://doi.org/10.1039/d1sc05721a
https://doi.org/10.1039/d1sc05721a
Autor:
Carlotta Granchi, Alice Capecchi, Gianluca Del Frate, Adriano Martinelli, Marco Macchia, Filippo Minutolo, Tiziano Tuccinardi
Publikováno v:
Molecules, Vol 20, Iss 5, Pp 8772-8790 (2015)
The human muscle isoform of lactate dehydrogenase (hLDH5) is one of the key enzymes of the glycolytic process. It is overexpressed in metastatic cancer cells and is linked to the vitality of tumors in hypoxic conditions. With the aim of identifying n
Externí odkaz:
https://doaj.org/article/744b7d4227654db7acaeec9e82f7e5ab
Autor:
Henry Valeyre, Pushpak Pati, Federico Gossi, Vignesh Ram Somnath, Adriano Martinelli, Maria Anna Rapsomaniki
Recent research has shown that the three-dimensional (3D) genome structure is strongly linked to cell function. Modeling the 3D genome structure can not only elucidate vital biological processes, but also reveal structural disruptions linked to disea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17432d3470720d917281f3177d579b0c
https://doi.org/10.1101/2022.11.15.516571
https://doi.org/10.1101/2022.11.15.516571
Recent advances in single-cell technologies have enabled the simultaneous quantification of multiple biomolecules in the same cell, opening new avenues for understanding cellular complexity and heterogeneity. However, the resulting multimodal single-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bad1b787ccb1d7402d7ad833735abbd9
https://doi.org/10.1101/2022.11.16.516751
https://doi.org/10.1101/2022.11.16.516751
Autor:
Adriano Martinelli, Nicholas Favalli, Dario Neri, Sebastian Oehler, Gabriele Bassi, Marco Catalano, Jörg Scheuermann
Publikováno v:
Biochem Biophys Res Commun
Biochemical and Biophysical Research Communications, 533 (2)
Biochemical and Biophysical Research Communications, 533 (2)
DNA-encoded chemical libraries (DEL) are increasingly being used for the discovery and optimization of small organic ligands to proteins of biological or pharmaceutical interest. The DNA fragments, that serve as amplifiable identification barcodes fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::272d92cc50a7b6b388aa890935316175
https://doi.org/10.1016/j.bbrc.2020.04.035
https://doi.org/10.1016/j.bbrc.2020.04.035
Autor:
Isabella Caligiuri, Gabriella Maria Pia Ortore, Tiziano Tuccinardi, Giulio Poli, Flavio Rizzolio, Adriano Martinelli
Background: The progression of ovarian cancer seems to be related to HDAC1, HDAC3, and HDAC6 activity. A possible strategy for improving therapies for treating ovarian carcinoma, minimizing the preclinical screenings, is the repurposing of already ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b73491caec8c57cef5fdf35d110cfc6
https://hdl.handle.net/10278/5021106
https://hdl.handle.net/10278/5021106
Autor:
Filippo Minutolo, Simone Bertini, Adriano Martinelli, Gabriella Ortore, Giorgio Placanica, Giovanni Prota, Simona Rapposelli, Tiziano Tuccinardi, Shubin Sheng, Kathryn E. Carlson, Benita S. Katzenellenbogen, John A. Katzenellenbogen, Marco Macchia
Publikováno v:
ARKIVOC, Vol 2006, Iss 8, Pp 83-94 (2006)
Externí odkaz:
https://doaj.org/article/edb5b22c6e74416abbf70506d172d6c4