Zobrazeno 1 - 10
of 65
pro vyhledávání: '"and Adrian D. Nunn"'
Autor:
Aurélie Prignon, Claire Provost, Jean-Noël Talbot, Françoise Montravers, Adrian D. Nunn, Laura E. Lantry, Aldo Cagnolini, Anne Gruaz-Guyon, Valérie Nataf
Publikováno v:
Nuclear Medicine and Biology. 42:92-98
Introduction AMBA is a bombesin analogue that binds to GRPr. In a mouse model of estrogen-dependent human breast cancer, we tested whether 68 Ga-AMBA can be used for PET detection of GRPr-expressing tumors and could be more accurate than 18 F-FDG to
Autor:
Laura E. Lantry, Michael F. Tweedle, Adrian D. Nunn, Karen E. Linder, Aldo Cagnolini, Jianqing Chen, Jaclyn Fox, Weiwei Feng, Mary Ellen Maddalena
Publikováno v:
Journal of Nuclear Medicine. 50:2017-2024
(177)Lu-DO3A-CH(2)CO-G-4-aminobenzoyl-Q-W-A-V-G-H-L-M-NH(2) ((177)Lu-AMBA) is a radiolabeled bombesin derivative that is bound and internalized by cells expressing the G-protein-coupled gastrin-releasing peptide receptor (GRP-R) and is currently in p
Autor:
Natarajan Raju, Edmund Metcalfe, Jianqing Chen, Laura E. Lantry, Aldo Cagnolini, Weiwei Feng, Hong Fan, Karen E. Linder, Stephen M. Eaton, Rolf E. Swenson, Adrian D. Nunn, Thangavel Arunachalam
Publikováno v:
Bioconjugate Chemistry. 20:1171-1178
The metabolism of (177)Lu-AMBA (AMBA = DO3A-CH(2)CO-G-(4-aminobenzoyl)-QWAVGHLM-NH(2)), a radiotherapeutic compound in clinical development that binds to GRP and NMB receptors, was studied in vitro (mouse, rat and human plasma, mouse kidney homogenat
Publikováno v:
Current Pharmaceutical Design. 15:675-681
Recent advances in designing peptide ligands for therapeutic targets are making peptides an attractive alternative to small molecules and proteins. It is now common to see peptides developed with affinities comparable to antibodies and specificities
Autor:
Adrian D. Nunn
Publikováno v:
Cancer Biotherapy and Radiopharmaceuticals. 22:722-739
The Food and Drug Administration has described their view of the role that imaging will play in the approval, and perhaps postapproval, use of new therapeutic drugs. The therapeutic drug industry and regulatory authorities have turned to imaging to h
Autor:
Kondareddiar Ramalingam, Natarajan Raju, Nancy J. Bogdan, Steve Eaton, Edmund R. Marinelli, Mathew A. Von Wronski, Thangavel Arunachalam, Sibylle Pochon, Palaniappa Nanjappan, Pillai Radhakrishna, Michael F. Tweedle, Adrian D. Nunn, Feng Yan, Karen E. Linder
Publikováno v:
Journal of Biological Chemistry. 281:5702-5710
Tuftsin, Thr-Lys-Pro-Arg (TKPR), is an immunostimulatory peptide with reported nervous system effects as well. We unexpectedly found that tuftsin and a higher affinity antagonist, TKPPR, bind selectively to neuropilin-1 and block vascular endothelial
Autor:
Jean-Marc Hyvelin, Catherine Botteron, Isabelle Tardy, Delphine Colevret, Mathew A. Von Wronski, Thierry Bettinger, Peter Frinking, Philippe Bussat, Adrian D. Nunn, Anne Lassus, François Tranquart, Maria Costa, Patricia Emmel
Publikováno v:
Investigative radiology. 49(4)
The diagnosis of acute coronary syndrome remains challenging especially in patients without clear symptoms or electrocardiographic and/or biomarker features. A hallmark of ischemia/reperfusion is activation of endothelial cells leading to altered exp
Autor:
Sang Kang, Xun Zhang, Ramachandran S. Ranganathan, Maria Fernandez, K. M. R. Pillai, Peter C. Ratsep, Michael F. Tweedle, Adrian D. Nunn
Publikováno v:
Investigative Radiology. 33:779-797
The authors investigated the effect of multimerization on the relaxivity of macrocyclic gadolinium (Gd) chelates. The objective was to develop more sensitive magnetic resonance imaging (MRI) contrast agents to study biochemical processes.Covalently l
Autor:
H W Strauss, Paul W. Wedeking, Maria Fernandez, Michael F. Tweedle, Adrian D. Nunn, Xun Zhang
Publikováno v:
INVESTIGATIVE RADIOLOGY. 32:802-805
RATIONALE AND OBJECTIVES The authors demonstrate the feasibility of monitoring renal status continuously and noninvasively at a patient's bedside, avoiding both radioactivity and blood and urine samples. METHODS Gadolinium-153-labeled ProHance and a