Zobrazeno 1 - 6
of 6
pro vyhledávání: '"analogs & derivatives [Catechin]"'
Autor:
Markus Zweckstetter, Tiago F. Outeiro, Annekatrin König, Antonio Dominguez-Meijide, Alain Ibáñez de Opakua, Sergey Ryazanov, Andrei Leonov, Christian Griesinger, Maria-Sol Cima-Omori, Eftychia Vasili
Publikováno v:
Scientific Reports
Scientific reports 10(1), 12827 (2020). doi:10.1038/s41598-020-69744-y
Scientific Reports, Vol 10, Iss 1, Pp 1-18 (2020)
Scientific reports 10(1), 12827 (2020). doi:10.1038/s41598-020-69744-y
Scientific Reports, Vol 10, Iss 1, Pp 1-18 (2020)
Parkinson's disease (PD) and Alzheimer's disease (AD) are common neurodegenerative disorders of the elderly and, therefore, affect a growing number of patients worldwide. Both diseases share, as a common hallmark, the accumulation of characteristic p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::903b3e0459c4302fe89a41ea5e55c9f5
https://hdl.handle.net/21.11116/0000-0008-7D9B-E21.11116/0000-0008-7D97-2
https://hdl.handle.net/21.11116/0000-0008-7D9B-E21.11116/0000-0008-7D97-2
Autor:
Wolfgang H. Oertel, Madeleine Schuberth, Jan Kassubek, Joseph Classen, Alexander L. Gerbes, Günter U. Höglinger, Birgit Ertl-Wagner, Martina Schneider, Alexia Moldovan, Gesine Respondek, Benno F. Zimmermann, Anna Noda, Alexander Storch, Stefan Jun Groiss, Ingrid Ricard, Daniela Berg, Jens Ebentheuer, Gregor K. Wenning, Friedemann Paul, Eva Schäffer, Ulrich Mansmann, Martin Südmeyer, Daniel Kroneberg, Heidi Pape, Doreen Gruber, Dávid Vadász, Walter J. Schulz-Schaeffer, Cornelia Eberhardt, Cornelia Skowronek, M. Kunz, Matthias Löhle, Thomas Kirchner, Monica Canelo, Sylvia Maaß, Werner Poewe, Armin Giese, Alexander Münchau, Karla Eggert, Marco Düring, Florin Gandor, Christian J. Hartmann, Johannes Schwarz, Johannes Levin, Elisabeth André, Silvia Egert-Schwender, Axel Lipp, Claudia Trenkwalder, Vera Tadic, Christopher Fricke, Hans-Jürgen Huppertz, Stefan Lorenzl, Brit Mollenhauer, Alfons Schnitzler, Christiane Blankenstein, Kai Bötzel
Publikováno v:
The lancet / Neurology 18(8), 724-735 (2019). doi:10.1016/S1474-4422(19)30141-3
Ann Transl Med
Ann Transl Med
Summary Background Multiple system atrophy is a rare neurodegenerative disease characterised by aggregation of α-synuclein in oligodendrocytes and neurons. The polyphenol epigallocatechin gallate inhibits α-synuclein aggregation and reduces associa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dc94785c39dcd80b97c3a573814de10
Autor:
Cox, Carla J., Choudhry, Fahd, Peacey, Eleanor, Perkinton, Michael S., Richardson, Jill C., Howlett, David R., Lichtenthaler, Stefan F., Francis, Paul T., Williams, Robert J.
Publikováno v:
Neurobiology of Aging
Cox, C J, Choudhry, F, Peacey, E, Perkinton, M S, Richardson, J C, Howlett, D R, Lichtenthaler, S F, Francis, P T & Williams, R J 2015, ' Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing ', Neurobiology of Aging, vol. 36, no. 1, pp. 178-187 . https://doi.org/10.1016/j.neurobiolaging.2014.07.032
Neurobiology of aging 36(1), 178-187 (2015). doi:10.1016/j.neurobiolaging.2014.07.032
Cox, C J, Choudhry, F, Peacey, E, Perkinton, M S, Richardson, J C, Howlett, D R, Lichtenthaler, S F, Francis, P T & Williams, R J 2015, ' Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing ', Neurobiology of Aging, vol. 36, no. 1, pp. 178-187 . https://doi.org/10.1016/j.neurobiolaging.2014.07.032
Neurobiology of aging 36(1), 178-187 (2015). doi:10.1016/j.neurobiolaging.2014.07.032
Flavonoids, a group of dietary polyphenols have been shown to possess cognitive health benefits. Epidemiologic evidence suggests that they could play a role in risk reduction in dementia. Amyloid precursor protein processing and the subsequent genera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::7a89487969e9f50a87ab73593a90a19b
http://europepmc.org/articles/PMC4270442
http://europepmc.org/articles/PMC4270442
Autor:
Levin, Johannes, Maaß, Sylvia, Poewe, Werner, Wenning, Gregor, group, PROMESA study, Giese, Armin, Bötzel, Kai, Höglinger, Günter, Berg, D., Claßen, J., Ebersbach, G., Eggert, K., Schuberth, Madeleine, Kassubek, J., Lipp, A., Löhle, M., Mollenhauer, B., Münchau, A., Südmeyer, M., Blankenstein, C., Eberhardt, C., Ertl-Wagner, B., Heise, H., Respondek, Gesine, Ricard, I., Zedler, S., Bötzel, K., Lorenzl, S., Schwarz, J., Paul, F., Gerbes, A., Paul, Friedemann, Mansmann, Ullrich, Oertel, Wolfgang H, Lorenzl, Stefan, Krismer, Florian, Seppi, Klaus
Publikováno v:
Journal of neural transmission 123(4), 439-445 (2016). doi:10.1007/s00702-016-1507-8
Formation of toxic α-synuclein oligomers appears to be a key underlying pathological mechanism of synucleinopathies such as Parkinson's disease or multiple system atrophy (MSA). Given that Epigallocatechin-gallate has been shown to inhibit α-synucl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2370365d34b0762d3a0d27af8e10306
https://pub.dzne.de/record/138472
https://pub.dzne.de/record/138472
Autor:
R.I. Téllez-Ballesteros, Mario O. Torres-Pérez, Gerardo Ramírez-Rodríguez, Leonardo Ortiz-López, Gerd Kempermann, Muhammad Ichwan, Ariadna Gómez-Sánchez, M.D.C. Silva-Lucero, Berenice Márquez-Valadez, Marco Antonio Meraz-Ríos
Publikováno v:
Neuroscience 322, 208-220 (2016). doi:10.1016/j.neuroscience.2016.02.040
Epigallo-catechin-3-gallate (EGCG), found in the leaves of Camellia sinensis (green tea), has antioxidant- and scavenger-functions and acts neuroprotectively. It has been publicized as anti-aging remedy but data on potential cellular mechanisms are s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::953171df0ea8df78515a0b90dd698239
https://pubmed.ncbi.nlm.nih.gov/26917271
https://pubmed.ncbi.nlm.nih.gov/26917271
Tracking CNS and systemic sources of oxidative stress during the course of chronic neuroinflammation
Autor:
Josephine Herz, Agata Mossakowski, Helena Radbruch, Josef Priller, Michael Boschmann, Markus Bock, Leonard Viohl, Jenny Gerhard, Karolin Pollok, Moritz Radbruch, Florence Pache, Carmen Infante-Duarte, Anja Mähler, Janina Behrens, Daniel Bremer, Randall L. Lindquist, Raluca Niesner, Anja E. Hauser, Markus Bardua, Martina Füchtemeier, Julian Pohlan, Judith Bellmann-Strobl, Ronja Mothes, Jan Leo Rinnenthal, Friedemann Paul, Jason M. Millward
Publikováno v:
Acta neuropathologica 130(6), 799-814 (2015). doi:10.1007/s00401-015-1497-x
Acta Neuropathologica
Mossakowski, A A, Pohlan, J, Bremer, D, Lindquist, R, Millward, J M, Bock, M, Pollok, K, Mothes, R, Viohl, L, Radbruch, M, Gerhard, J, Bellmann-Strobl, J, Behrens, J, Infante-Duarte, C, Mähler, A, Boschmann, M, Rinnenthal, J L, Füchtemeier, M, Herz, J, Pache, F C, Bardua, M, Priller, J, Hauser, A E, Paul, F, Niesner, R & Radbruch, H 2015, ' Tracking CNS and systemic sources of oxidative stress during the course of chronic neuroinflammation ', Acta Neuropathologica, vol. 130, no. 6, pp. 799-814 . https://doi.org/10.1007/s00401-015-1497-x
Acta Neuropathologica
Mossakowski, A A, Pohlan, J, Bremer, D, Lindquist, R, Millward, J M, Bock, M, Pollok, K, Mothes, R, Viohl, L, Radbruch, M, Gerhard, J, Bellmann-Strobl, J, Behrens, J, Infante-Duarte, C, Mähler, A, Boschmann, M, Rinnenthal, J L, Füchtemeier, M, Herz, J, Pache, F C, Bardua, M, Priller, J, Hauser, A E, Paul, F, Niesner, R & Radbruch, H 2015, ' Tracking CNS and systemic sources of oxidative stress during the course of chronic neuroinflammation ', Acta Neuropathologica, vol. 130, no. 6, pp. 799-814 . https://doi.org/10.1007/s00401-015-1497-x
The functional dynamics and cellular sources of oxidative stress are central to understanding MS pathogenesis but remain elusive, due to the lack of appropriate detection methods. Here we employ NAD(P)H fluorescence lifetime imaging to detect functio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2959d06d699d7087efdfe9b712adf23a
https://pub.dzne.de/record/138235
https://pub.dzne.de/record/138235