Zobrazeno 1 - 10
of 3 959
pro vyhledávání: '"amyotrophic lateral sclerosis (als)"'
Autor:
Richa Gupta, Mansi Bhandari, Anhad Grover, Taher Al-shehari, Mohammed Kadrie, Taha Alfakih, Hussain Alsalman
Publikováno v:
BioData Mining, Vol 17, Iss 1, Pp 1-11 (2024)
Abstract This research presents a predictive model aimed at estimating the progression of Amyotrophic Lateral Sclerosis (ALS) based on clinical features collected from a dataset of 50 patients. Important features included evaluations of speech, mobil
Externí odkaz:
https://doaj.org/article/d8c2674708d54ff4a0aed70e2781d6eb
Autor:
Ilaria Martinelli, Jessica Mandrioli, Andrea Ghezzi, Elisabetta Zucchi, Giulia Gianferrari, Cecilia Simonini, Francesco Cavallieri, Franco Valzania
Publikováno v:
Neural Regeneration Research, Vol 20, Iss 1, Pp 130-138 (2025)
Amyotrophic lateral sclerosis (ALS) is a neuromuscular condition resulting from the progressive degeneration of motor neurons in the cortex, brainstem, and spinal cord. While the typical clinical phenotype of ALS involves both upper and lower motor n
Externí odkaz:
https://doaj.org/article/0208827a07b44cb9bfdaaf5a41d406a3
Autor:
Cinzia Femiano, Antonio Bruno, Luana Gilio, Fabio Buttari, Ettore Dolcetti, Giovanni Galifi, Federica Azzolini, Angela Borrelli, Roberto Furlan, Annamaria Finardi, Alessandra Musella, Georgia Mandolesi, Marianna Storto, Diego Centonze, Mario Stampanoni Bassi
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Experimental studies identified a role of neuroinflammation in the pathogenesis of neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). However, the role of inflammatory molecules as diagnostic and prognostic biomarkers
Externí odkaz:
https://doaj.org/article/1f57bd670cb64b908210235a78a09890
Autor:
Jill Carlton, Philip Powell, Donna Rowen, Claire Williams, Alys Wyn Griffiths, Esther Hobson, Christopher McDermott
Publikováno v:
Health and Quality of Life Outcomes, Vol 22, Iss 1, Pp 1-8 (2024)
Abstract Background Patient reported outcome measures (PROMs) can be used to assess the impact of health conditions upon an individual’s health-related quality of life (HRQoL). Whilst PROMs have been used to quantify the HRQoL impact of amyotrophic
Externí odkaz:
https://doaj.org/article/9f70e66277aa471cb2bfc1d74b204488
Publikováno v:
BMC Palliative Care, Vol 23, Iss 1, Pp 1-14 (2024)
Abstract Background Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease of the upper and lower motoneuron. It is associated with a life expectancy of 2–4 years after diagnosis. Individuals experience paralysis, dysphagia, respiratory
Externí odkaz:
https://doaj.org/article/9851dd722de5457f82e0988b581c78ff
Autor:
Chris Kato, Koji Ueda, Satoru Morimoto, Shinichi Takahashi, Shiho Nakamura, Fumiko Ozawa, Daisuke Ito, Yugaku Daté, Kensuke Okada, Naoki Kobayashi, Jin Nakahara, Hideyuki Okano
Publikováno v:
Inflammation and Regeneration, Vol 44, Iss 1, Pp 1-18 (2024)
Abstract Background Extracellular vesicles (EVs) hold the potential for elucidating the pathogenesis of amyotrophic lateral sclerosis (ALS) and serve as biomarkers. Notably, the comparative and longitudinal alterations in the protein profiles of EVs
Externí odkaz:
https://doaj.org/article/166542d458c04fcaa788a27b67f26db5
Publikováno v:
Dubai Medical Journal, Vol 7, Iss 3 (2024)
Introduction: Amyotrophic lateral sclerosis (ALS), a neurodegenerative disease that causes muscle weakness, paralysis, and death, develops when motor neurons begin to die. There are few proven treatments for ALS, and because the disease is incurable,
Externí odkaz:
https://doaj.org/article/c99b5a7715c9470cb3c7be9d0e1c5ed5
Autor:
Xena G. Pappalardo, Giorgio Jansen, Matteo Amaradio, Jole Costanza, Renato Umeton, Francesca Guarino, Vito De Pinto, Stephen G. Oliver, Angela Messina, Giuseppe Nicosia
Publikováno v:
Heliyon, Vol 10, Iss 23, Pp e40696- (2024)
One of the most robust approaches to the prediction of causal driver genes of complex diseases is to apply reverse engineering methods to infer a gene regulatory network (GRN) from gene expression profiles (GEPs). In this work, we analysed 794 GEPs o
Externí odkaz:
https://doaj.org/article/fd5a9139f9cf4c0d928cf7ebc42c4865