Zobrazeno 1 - 10
of 2 901
pro vyhledávání: '"amyloid-β peptide"'
Publikováno v:
Bone Reports, Vol 22, Iss , Pp 101788- (2024)
Objective: To explore the effect of amyloid-β peptide (Aβ) on mandibular condyle to develop a new treatment for postmenopausal women with Temporomandibular joint osteoarthritis. Methods: A murine bone loss model was established by ovariectomy. Micr
Externí odkaz:
https://doaj.org/article/3279f129bc7043248056834355bb4e15
Autor:
Mengni Bao, Xiumeng Hua, Xiao Chen, Tao An, Han Mo, Zhe Sun, Menghao Tao, Guangxin Yue, Jiangping Song
Publikováno v:
Advanced Science, Vol 11, Iss 32, Pp n/a-n/a (2024)
Abstract Anthracyclines are chemotherapeutic drugs used to treat solid and hematologic malignancies. However, life‐threatening cardiotoxicity, with cardiac dilation and heart failure, is a drawback. A combination of in vivo for single cell/nucleus
Externí odkaz:
https://doaj.org/article/45602eb2431f42e7b4a48e6d2af685d4
A single-domain antibody detects and neutralises toxic Aβ42 oligomers in the Alzheimer’s disease CSF
Autor:
Alessandra Bigi, Liliana Napolitano, Devkee M. Vadukul, Fabrizio Chiti, Cristina Cecchi, Francesco A. Aprile, Roberta Cascella
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-19 (2024)
Abstract Background Amyloid-β42 (Aβ42) aggregation consists of a complex chain of nucleation events producing soluble oligomeric intermediates, which are considered the major neurotoxic agents in Alzheimer’s disease (AD). Cerebral lesions in the
Externí odkaz:
https://doaj.org/article/e31cb433d4c24d6992d739c228d88a50
Autor:
Hugo Fanlo-Ucar, Pol Picón-Pagès, Víctor Herrera-Fernández, Gerard ILL-Raga, Francisco J. Muñoz
Publikováno v:
Antioxidants, Vol 13, Iss 10, p 1208 (2024)
Alzheimer’s disease (AD) is a progressive neurodegenerative disease, and it is currently the seventh leading cause of death worldwide. It is characterized by the extracellular aggregation of the amyloid β-peptide (Aβ) into oligomers and fibrils t
Externí odkaz:
https://doaj.org/article/8128c43c4f4b483a911efe7e1dbb65cb
Autor:
Lianmeng Ye, Jiazheng Zhao, Zhengpan Xiao, Wenyu Gu, Xiaoxuan Liu, Nuela Manka’a Che Ajuyo, Yi Min, Yechun Pei, Dayong Wang
Publikováno v:
Antioxidants, Vol 13, Iss 10, p 1274 (2024)
Alzheimer’s disease (AD) is an intractable and progressive neurodegenerative disease. Amyloid beta (Aβ) aggregation is the hallmark of AD. Aβ induces neurotoxicity through a variety of mechanisms, including interacting with membrane receptors to
Externí odkaz:
https://doaj.org/article/95720e65beb545ee9d69149829e1313c
Autor:
Panagis Polykretis, Cristiano D’Andrea, Martina Banchelli, Liliana Napolitano, Roberta Cascella, Marella de Angelis, Paolo Matteini
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
Introduction: Alzheimer’s disease (AD) is a progressive debilitating neurological disorder representing the most common neurodegenerative disease worldwide. Although the exact pathogenic mechanisms of AD remain unresolved, the presence of extracell
Externí odkaz:
https://doaj.org/article/dce15d66ff4e4beb8d050cb8c9361eb1
Autor:
Rina Nakamura, Akira Matsuda, Youichirou Higashi, Yoshihiro Hayashi, Motomi Konishi, Motoaki Saito, Toshifumi Akizawa
Publikováno v:
Biomolecules, Vol 14, Iss 10, p 1234 (2024)
There is a high demand for the development of drugs against Alzheimer’s disease (AD), which is related to the misfolding and aggregation of Amyloid-β (Aβ), due to the increasing number of patients with AD. In our present study, we aimed to assess
Externí odkaz:
https://doaj.org/article/2287809782bf4085b2ad3699ae513316
Publikováno v:
Molecules, Vol 29, Iss 15, p 3460 (2024)
The kinetics of amyloid aggregation was studied indirectly by monitoring the changes in the polydispersity of mixed dispersion of amyloid β peptide (1-40) and composite liposomes. The liposomes were prepared from the 1,2-dioleoyl-sn-glicero-3-phosho
Externí odkaz:
https://doaj.org/article/0717c9186e1744ddba92e47894f413d4
Autor:
Shingo Ito, Ryotaro Yagi, Seiryo Ogata, Takeshi Masuda, Takashi Saito, Takaomi Saido, Sumio Ohtsuki
Publikováno v:
Fluids and Barriers of the CNS, Vol 20, Iss 1, Pp 1-18 (2023)
Abstract Background Blood–brain barrier (BBB) dysfunction is supposed to be an early event in the development of Alzheimer’s disease (AD). This study aimed to investigate the relationship between BBB alterations and AD progression in terms of amy
Externí odkaz:
https://doaj.org/article/1d1f5cd2de80492c90140b8c3d4e5a3c
Publikováno v:
Food Science and Human Wellness, Vol 12, Iss 5, Pp 1905-1916 (2023)
Amyloid-β 1-42 (Aβ42) plays a pivotal role in Alzheimer disease (AD) pathogenesis. Peripheral clearance of Aβ42 largely affects its level in the brain and affects AD progression. Although nattokinase (NK) degrades Aβ40, the details of NK’s capt
Externí odkaz:
https://doaj.org/article/393922eb1a64417bb30b256058c3b1db