Zobrazeno 1 - 10
of 19 379
pro vyhledávání: '"amyloid-β"'
Publikováno v:
Exploration of Neuroprotective Therapy, Vol 4, Iss 5, Pp 401-410 (2024)
Alzheimer’s disease (AD) is the leading cause of dementia worldwide. The disease is characterized by the abnormal accumulation of amyloid β (Aβ) protein creating neuritic plaques, hyperphosphorylated tau (p-tau) protein forming intracellular tang
Externí odkaz:
https://doaj.org/article/2cb8f8113bc0467cbebea2f05de6f393
Autor:
Laura García-Pupo, Lucie Crouzier, Alberto Bencomo-Martínez, Johann Meunier, Axelle Morilleau, Benjamin Delprat, Marquiza Sablón Carrazana, Roberto Menéndez Soto del Valle, Tangui Maurice, Chryslaine Rodríguez-Tanty
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 10, Pp 4345-4359 (2024)
The aggregation of Amyloid-β (Aβ) peptides is associated with neurodegeneration in Alzheimer's disease (AD). We previously identified novel naphtalene derivatives, including the lead compound Amylovis-201, able to form thermodynamically stable comp
Externí odkaz:
https://doaj.org/article/26f1239b7fa54d17870873e42f89e4c4
Autor:
Wanassanun Pannangrong, Nutchareeporn Nillert, Chantana Boonyarat, Jariya Umka Welbat, Supataechasit Yannasithinon, Pannawat Choowong-In
Publikováno v:
BMC Complementary Medicine and Therapies, Vol 24, Iss 1, Pp 1-12 (2024)
Abstract Background Clausena harmandiana (CH), commonly known as song fa dong, was a medicinal plant traditionally used to treat illnesses and as a health tonic. CH root extract (CHRE) exhibited various bioactivities, including neuroprotective, antio
Externí odkaz:
https://doaj.org/article/e5f38a2453a44b7c868ad32aab7978b5
Autor:
Pasqua Abbrescia, Gianluca Signorile, Onofrio Valente, Claudia Palazzo, Antonio Cibelli, Grazia Paola Nicchia, Antonio Frigeri
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-12 (2024)
Abstract The water channel aquaporin-4 (AQP4) is crucial for water balance in the mammalian brain. AQP4 has two main canonical isoforms, M23, which forms supramolecular structures called Orthogonal Arrays of Particles (OAP) and M1, which does not, al
Externí odkaz:
https://doaj.org/article/ce042aa164974a94b9630f31a2697004
Autor:
Jinghuan Gan, Ziming Xu, Zhichao Chen, Shuai Liu, Hao Lu, Yajie Wang, Hao Wu, Zhihong Shi, Huijun Chen, Yong Ji
Publikováno v:
Fluids and Barriers of the CNS, Vol 21, Iss 1, Pp 1-13 (2024)
Abstract Background Blood–brain barrier (BBB) dysfunction has been viewed as a potential underlying mechanism of neurodegenerative disorders, possibly involved in the pathogenesis and progression of Alzheimer’s disease (AD). However, a relation b
Externí odkaz:
https://doaj.org/article/0aa19b182d1247499f57ec8b7a8bb423
Autor:
Charlotte Johansson, Steinunn Thordardottir, José Laffita-Mesa, Josef Pannee, Elena Rodriguez-Vieitez, Henrik Zetterberg, Kaj Blennow, Caroline Graff
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-11 (2024)
Abstract Background Several blood-based biomarkers offer the opportunity of in vivo detection of brain pathology and neurodegeneration in Alzheimer disease with high specificity and sensitivity, but the performance of amyloid-β (Aβ) measurements re
Externí odkaz:
https://doaj.org/article/f749f6d7e7b74fc1adaf158a55ea204e
Autor:
Jeonghun Kim, Sang-Il Suh, Yu Jeong Park, Minwoong Kang, Su Jin Chung, Eun Seong Lee, Hye Na Jung, Jae Seon Eo, Seong-Beom Koh, Kyungmi Oh, Sung Hoon Kang
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-8 (2024)
Abstract Low body mass index is closely related to a high risk of Alzheimer’s disease (AD) and related biomarkers including amyloid-β (Aβ) deposition. However, the association between sarcopenia and Aβ-confirmed AD remains controversial. Therefo
Externí odkaz:
https://doaj.org/article/89ec1166ba734c9b8b6762f252849c4e
Autor:
Yanli Zhang, Tian Li, Jie Miao, Zhina Zhang, Mingxuan Yang, Zhuoran Wang, Bo Yang, Jiawei Zhang, Haiting Li, Qiang Su, Junhong Guo
Publikováno v:
Neural Regeneration Research, Vol 20, Iss 2, Pp 533-547 (2025)
In patients with Alzheimer’s disease, gamma-glutamyl transferase 5 (GGT5) expression has been observed to be downregulated in cerebrovascular endothelial cells. However, the functional role of GGT5 in the development of Alzheimer’s disease remain
Externí odkaz:
https://doaj.org/article/d81ff55711794bcdb8272084820874d7
Autor:
Mohammad Sadeghi, Ali Azargoonjahromi, Hamide Nasiri, Arash Yaghoobi, Maryam Sadeghi, Seyedeh Saeideh Chavoshi, Shilan Baghaeikia, Nastaran Mahzari, Arina Valipour, Romina Razeghi Oskouei, Farshad Shahkarami, Fatemeh Amiri, Mahsa Mayeli
Publikováno v:
Molecular Brain, Vol 17, Iss 1, Pp 1-11 (2024)
Abstract Mild Cognitive Impairment (MCI) is a neurological condition characterized by a noticeable decline in cognitive abilities that falls between normal aging and dementia. Along with some biomarkers like GAP-43, Aβ, tau, and P-tau, brain activit
Externí odkaz:
https://doaj.org/article/c34c32b9389b4ea69ac86b14062d046d
Publikováno v:
Translational Neurodegeneration, Vol 13, Iss 1, Pp 1-19 (2024)
Abstract Alzheimer’s disease (AD) is a progressive neurological disorder that primarily impacts cognitive function. Currently there are no disease-modifying treatments to stop or slow its progression. Recent studies have found that several peripher
Externí odkaz:
https://doaj.org/article/749ecde8b16b4a4c8134f029ec06c5a2