Zobrazeno 1 - 10
of 61
pro vyhledávání: '"amyloid beta protein[1-40]"'
Autor:
Fagan, Anne M, Henson, Rachel L, Lai, Florence, Rosas, H Diana, Schupf, Nicole, Krinsky-McHale, Sharon, Silverman, Wayne, Lee, Joseph H, Klunk, William E, Handen, Benjamin L, Allegri, Ricardo F, Chhatwal, Jasmeer P, Li, Yan, Day, Gregory S, Graff-Radford, Neill R, Jucker, Mathias, Levin, Johannes, Martins, Ralph N, Masters, Colin L, Mori, Hiroshi, Mummery, Catherine J, Niimi, Yoshiki, Ringman, John M, Boerwinkle, Anna H, Salloway, Stephen, Schofield, Peter R, Shoji, Mikio, Lott, Ira T, Syndrome, Alzheimer's Biomarker Consortium-Down, Network, Dominantly Inherited Alzheimer, Xiong, Chengjie, Bateman, Randall J, Goate, Alison, Ances, Beau M, Doran, Eric, Christian, Bradley T
Publikováno v:
The lancet / Neurology 20(8), 615-626 (2021). doi:10.1016/S1474-4422(21)00139-3
Lancet Neurol
Lancet Neurol
Due to trisomy of chromosome 21 and the resultant extra copy of the amyloid precursor protein gene, nearly all adults with Down syndrome develop Alzheimer's disease pathology by the age of 40 years and are at high risk for dementia given their increa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73e8e1e7a79ed1db0f682fd61a838c87
https://doi.org/10.1016/s1474-4422(21)00139-3
https://doi.org/10.1016/s1474-4422(21)00139-3
Autor:
Josef Priller, Marion Ortner, Achim Berthele, Marie-Sophie Franz, Paul Theo Zebhauser, Timo Grimmer, Oliver Goldhardt, Janine Diehl-Schmid
Publikováno v:
Journal of Alzheimer's disease 83(1), 155-162 (2021). doi:10.3233/JAD-210286
Background: Tau proteins are established biomarkers of neuroaxonal damage in a wide range of neurodegenerative conditions. Although measurement of total-Tau in the cerebrospinal fluid is widely used in research and clinical settings, the relationship
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9210b5be1ed4da8e4c38af31ecd072b
https://pubmed.ncbi.nlm.nih.gov/34250938
https://pubmed.ncbi.nlm.nih.gov/34250938
Autor:
Ina Vorberg, Pavithra Chandramowlishwaran, Meng Sun, Carmen Nussbaum-Krammer, Anastasiya V Grizel, Yury O. Chernoff, Kristin L Casey, Aleksandr A. Rubel, Andrey V. Romanyuk, Julia V. Sopova
Publikováno v:
The journal of biological chemistry 293(9), 3436-3450 (2018). doi:10.1074/jbc.M117.809004
Fibrous cross-β aggregates (amyloids) and their transmissible forms (prions) cause diseases in mammals (including humans) and control heritable traits in yeast. Initial nucleation of a yeast prion by transiently overproduced prion-forming protein or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ff3d4fc9f56554126697b81a6eddca8
https://doi.org/10.1074/jbc.m117.809004
https://doi.org/10.1074/jbc.m117.809004
Autor:
Jonathan Vogelgsang, Rebekka Vogelgsang, Jens Wiltfang, Hedieh Shahpasand-Kroner, Ruth Vukovich, Frank Streit
Publikováno v:
Experimental brain research 236(5), 1241-1250 (2018). doi:10.1007/s00221-018-5210-x
The cerebrospinal fluid (CSF) biomarkers amyloid-β42 (Aβ42), total Tau, and phospho-181-Tau represent important diagnostic tools to support the clinical diagnosis of Alzheimer's disease (AD). Acquiring CSF by lumbar puncture is considered a moderat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92ef8b0b3a53f6466c0f3074d80a7987
https://doi.org/10.1007/s00221-018-5210-x
https://doi.org/10.1007/s00221-018-5210-x
Autor:
Tanja Blume, Severin Filser, Etienne Herzog, Jochen Herms, Mario M. Dorostkar, Finn Peters, Derya R. Shimshek, Nils Brose, Hazal Salihoglu, Eva Ferreira Rodrigues, Ulf Neumann
Publikováno v:
Acta Neuropathologica
Acta Neuropathologica, Springer Verlag, 2018, 135 (5), pp.695-710. ⟨10.1007/s00401-017-1804-9⟩
Acta Neuropathologica (Berl)
Acta neuropathologica 135(5), 695-710 (2018). doi:10.1007/s00401-017-1804-9
Acta Neuropathologica, Springer Verlag, 2018, 135 (5), pp.695-710. ⟨10.1007/s00401-017-1804-9⟩
Acta Neuropathologica (Berl)
Acta neuropathologica 135(5), 695-710 (2018). doi:10.1007/s00401-017-1804-9
BACE1 is the rate-limiting protease in the production of synaptotoxic β-amyloid (Aβ) species and hence one of the prime drug targets for potential therapy of Alzheimer’s disease (AD). However, so far pharmacological BACE1 inhibition failed to res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af044c91d1bf50ef951bb3c095454513
https://doi.org/10.1007/s00401-017-1804-9
https://doi.org/10.1007/s00401-017-1804-9
Autor:
Juan Fortea, Sylvain Lehmann, Shahid Zaman, Victor Montal, Tiina Annus, Maria Carmona-Iragui, Sandra Giménez, Jordi Clarimón, Bessy Benejam, Valle Camacho, Teresa Estellés, Susana Fernández, Olivia Belbin, Laura Videla, Anthony J. Holland, Ricardo S. Osorio, Jordi Pegueroles, Alberto Lleó, Isabel Barroeta, Sílvia Valldeneu, Rafael Blesa, Liam R. Wilson, Sofía González-Ortiz, Miren Altuna, Laia Muñoz, Daniel Alcolea, Sebastián Videla, Eduard Vilaplana, Ignacio Illán-Gala
Publikováno v:
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
The Lancet
The Lancet, Elsevier, 2020, 395 (10242), pp.1988-1997. ⟨10.1016/S0140-6736(20)30689-9⟩
LANCET
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
Lancet (London, England)
Universitat Autònoma de Barcelona
The Lancet
The Lancet, Elsevier, 2020, 395 (10242), pp.1988-1997. ⟨10.1016/S0140-6736(20)30689-9⟩
LANCET
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
Lancet (London, England)
Background: Alzheimer's disease and its complications are the leading cause of death in adults with Down syndrome. Studies have assessed Alzheimer's disease in individuals with Down syndrome, but the natural history of biomarker changes in Down syndr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b6f93f6750e3702901633c6f25c3dc1
https://ddd.uab.cat/record/227832
https://ddd.uab.cat/record/227832
Autor:
Parinaz Massoumzadeh, Randall J. Bateman, John C. Morris, Colin L. Masters, Hiroshi Mori, Eric McDade, Peter R. Schofield, Carlos Cruchaga, Mathias Jucker, Richard J. Perrin, Tammie L.S. Benzinger, Jasmeer P. Chhatwal, Jonathan Vöglein, Jason Hassenstab, Elizabeth A. Grant, Chengjie Xiong, Neill R. Graff-Radford, Jingqin Luo, Marilyn S. Albert, Folasade Agboola, Anne M. Fagan, Bernardino Ghetti, Sterling C. Johnson
Publikováno v:
Neurology 95(23), e3104-e3116 (2020). doi:10.1212/WNL.0000000000010747
Neurology
Neurology
ObjectiveTo determine the ordering of changes in Alzheimer disease (AD) biomarkers among cognitively normal individuals.MethodsCross-sectional data, including CSF analytes, molecular imaging of cerebral fibrillar β-amyloid (Aβ) with PET using the [
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::accb5a8dcd4bb991084e13fdafa1e01c
Autor:
Gianluigi Forloni, Federica Fusco, Alessio Colombo, Emanuele Nardo, Ottavia Bernocchi, Gloria Biella, Diego Albani, Stefan F. Lichtenthaler
Publikováno v:
Journal of Alzheimer's disease 53(3), 1193-1207 (2016). doi:10.3233/JAD-151135
The neuropathological hallmarks of Alzheimer's disease (AD) are extracellular plaques built up by the accumulation of the amyloid-β protein precursor (AβPP)-derived peptide β (Aβ), and intracellular tangles of hyperphosphorylated tau protein. Sir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06dfe8bfcc867a7af76d2b0ddff1984d
https://doi.org/10.3233/jad-151135
https://doi.org/10.3233/jad-151135
Autor:
Shahpasand-Kroner, Hedieh, Klafki, Hans-W., Bauer, Chris, Schuchhardt, Johannes, Hüttenrauch, Melanie, Stazi, Martina, Bouter, Caroline, Wirths, Oliver, Vogelgsang, Jonathan, Wiltfang, Jens
Publikováno v:
Alzheimer's Research & Therapy
Alzheimer’s Research & Therapy, Vol 10, Iss 1, Pp 1-14 (2018)
Alzheimer's research & therapy 10(1), 121 (2018). doi:10.1186/s13195-018-0448-x
Alzheimer’s Research & Therapy, Vol 10, Iss 1, Pp 1-14 (2018)
Alzheimer's research & therapy 10(1), 121 (2018). doi:10.1186/s13195-018-0448-x
Background The quantification of amyloid-beta (Aβ) peptides in blood plasma as potential biomarkers of Alzheimer’s disease (AD) is hampered by very low Aβ concentrations and the presence of matrix components that may interfere with the measuremen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::7b4a61b33239e1ff1bb8f3d071c7470b
https://pubmed.ncbi.nlm.nih.gov/30526652
https://pubmed.ncbi.nlm.nih.gov/30526652
Autor:
Josef Priller, Michael Wagner, Michael T. Heneka, Anja Schneider, Laura Dobisch, Felix Menne, Alexandra Polcher, Annika Spottke, Emrah Düzel, Stefan J. Teipel, Eike Jakob Spruth, Christiana Franke, Martin Dyrba, Klaus Fliebach, Cihan Catak, René Thyrian, Dominik Diesing, Katharina Brueggen, Manuela Thelen, Ingo Kilimann, Frederic Brosseron, Frank Jessen, Oliver Peters, Katharina Buerger, Coraline D. Metzger, Barbara Kofler
Publikováno v:
Journal of Alzheimer's disease 64(3), 801-813 (2018). doi:10.3233/JAD-180106
Teipel, S J, Metzger, C, Brosseron, F, Buerger, K, Brueggen, K, Catak, C, Diesing, D, Dobisch, L, Fliebach, K, Franke, C, Heneka, M, Kilimann, I, Kofler, B, Menne, F, Peters, O, Polcher, A, Priller, J, Schneider, A, Spottke, A, Spruth, E J, Thelen, M, Thyrian, R J, Wagner, M, Düzel, E & Jessen, F & Dyrba, M 2018, ' Multicenter Resting State Functional Connectivity in Prodromal and Dementia Stages of Alzheimer's Disease ', Journal of Alzheimer's Disease . https://doi.org/10.3233/JAD-180106
Teipel, S J, Metzger, C, Brosseron, F, Buerger, K, Brueggen, K, Catak, C, Diesing, D, Dobisch, L, Fliebach, K, Franke, C, Heneka, M, Kilimann, I, Kofler, B, Menne, F, Peters, O, Polcher, A, Priller, J, Schneider, A, Spottke, A, Spruth, E J, Thelen, M, Thyrian, R J, Wagner, M, Düzel, E & Jessen, F & Dyrba, M 2018, ' Multicenter Resting State Functional Connectivity in Prodromal and Dementia Stages of Alzheimer's Disease ', Journal of Alzheimer's Disease . https://doi.org/10.3233/JAD-180106
BACKGROUND: Alterations of intrinsic networks from resting state fMRI (rs-fMRI) have been suggested as functional biomarkers of Alzheimer's disease (AD).OBJECTIVE: To determine the diagnostic accuracy of multicenter rs-fMRI for prodromal and preclini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::709520c0af7d5cecdc884e1ff647385d
https://pubmed.ncbi.nlm.nih.gov/29914027
https://pubmed.ncbi.nlm.nih.gov/29914027