The dual amylin and calcitonin receptor agonist KBP-336 elicits a unique combination of weight loss, antinociception and bone protection - a novel disease-modifying osteoarthritis drug.

Autor: Mohamed KE; Nordic Bioscience Biomarkers and Research, Herlev Hovedgade 207, Herlev, DK-2730, Denmark. kmo@nordicbio.com.; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark. kmo@nordicbio.com., Larsen AT; Nordic Bioscience Biomarkers and Research, Herlev Hovedgade 207, Herlev, DK-2730, Denmark., Melander S; Nordic Bioscience Biomarkers and Research, Herlev Hovedgade 207, Herlev, DK-2730, Denmark., Andersen F; Nordic Bioscience Biomarkers and Research, Herlev Hovedgade 207, Herlev, DK-2730, Denmark., Kerrn EB; Nordic Bioscience Biomarkers and Research, Herlev Hovedgade 207, Herlev, DK-2730, Denmark., Karsdal MA; Nordic Bioscience Biomarkers and Research, Herlev Hovedgade 207, Herlev, DK-2730, Denmark.; KeyBioscience AG, Stans, Switzerland., Henriksen K; Nordic Bioscience Biomarkers and Research, Herlev Hovedgade 207, Herlev, DK-2730, Denmark.; KeyBioscience AG, Stans, Switzerland.; Department of Molecular and Medical Biology, Roskilde University Center, Roskilde, Denmark.

Publikováno v: Arthritis research & therapy [Arthritis Res Ther] 2024 Jul 12; Vol. 26 (1), pp. 129. Date of Electronic Publication: 2024 Jul 12.

UTRs and Ago-2/miR-335 Complex Restricts Amylin Translation in Insulinoma and Human Pancreatic β-Cells.

Autor: Kudaibergenova, Zhanar¹ (AUTHOR) zhannkud81@gwmail.gwu.edu, Pany, Satyabrata¹ (AUTHOR), Placheril, Elizabeth¹ (AUTHOR), Jeremic, Aleksandar M.¹ (AUTHOR) jerema@gwu.edu

Publikováno v: International Journal of Molecular Sciences. Sep2024, Vol. 25 Issue 17, p9614. 14p.

DACRA induces profound weight loss, satiety control, and increased mitochondrial respiratory capacity in adipose tissue.

Autor: Petersen EA; Nordic Bioscience, Herlev, Denmark. eap@nordicbio.com.; Xlab, Center for Healthy Aging, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark. eap@nordicbio.com., Blom I; Xlab, Center for Healthy Aging, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark., Melander SA; Nordic Bioscience, Herlev, Denmark., Al-Rubai M; Nordic Bioscience, Herlev, Denmark.; Department of Science and Environment, Roskilde University, Roskilde, Denmark., Vidotto M; Nordic Bioscience, Herlev, Denmark., Dalgaard LT; Department of Science and Environment, Roskilde University, Roskilde, Denmark., Karsdal MA; Nordic Bioscience, Herlev, Denmark.; KeyBioscience AG, Stans, Switzerland., Henriksen K; Nordic Bioscience, Herlev, Denmark.; Department of Science and Environment, Roskilde University, Roskilde, Denmark.; KeyBioscience AG, Stans, Switzerland., Larsen S; Xlab, Center for Healthy Aging, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Research Centre, Medical University of Bialystok, Bialystok, Poland.; Institute of Sports Medicine Copenhagen, Department of Orthopedic Surgery M, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark., Larsen AT; Nordic Bioscience, Herlev, Denmark.

Publikováno v: International journal of obesity (2005) [Int J Obes (Lond)] 2024 Oct; Vol. 48 (10), pp. 1421-1429. Date of Electronic Publication: 2024 Jun 15.

Exploring the central region of amylin and its analogs aggregation: the influence of metal ions and residue substitutions.

Autor: Alghrably, Mawadda¹, Bennici, Giulia¹, Szczupaj, Gabriela^1,2, Alasmael, Noura³, Qutub, Somayah⁴, Maatouk, Batoul⁴, Chandra, Kousik¹, Nowakowski, Michal², Emwas, Abdul-Hamid⁵, Jaremko, Mariusz¹ mariusz.jaremko@kaust.edu.sa, Sánchez-López,, Carolina⁶, Wenqi Shen⁷

Publikováno v: Frontiers in Chemistry. 2024, p01-18. 18p.

Zinc and pH modulate the ability of insulin to inhibit aggregation of islet amyloid polypeptide.

Autor: McCalpin, Samuel D.^1,2 (AUTHOR), Khemtemourian, Lucie³ (AUTHOR), Suladze, Saba^4,5 (AUTHOR), Ivanova, Magdalena I.^1,6,7 (AUTHOR), Reif, Bernd^4,5 (AUTHOR), Ramamoorthy, Ayyalusamy^1,2,6,7,8,9 (AUTHOR) ramamoor@umich.edu

Publikováno v: Communications Biology. 6/27/2024, Vol. 7 Issue 1, p1-12. 12p.