Výsledky vyhledávání - "aminopyridine-3"

4-Heteroaryl Substituted Amino-3,5-Dicyanopyridines as New Adenosine Receptor Ligands: Novel Insights on Structure-Activity Relationships and Perspectives

Autor: Daniela Catarzi, Flavia Varano, Erica Vigiani, Sara Calenda, Fabrizio Melani, Katia Varani, Fabrizio Vincenzi, Silvia Pasquini, Natascia Mennini, Giulia Nerli, Diego Dal Ben, Rosaria Volpini, Vittoria Colotta

Publikováno v: Pharmaceuticals; Volume 15; Issue 4; Pages: 478

A new set of amino-3,5-dicyanopyridines was synthesized and biologically evaluated at the adenosine receptors (ARs). This chemical class is particularly versatile, as small structural modifications can influence not only affinity and selectivity, but

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::257e6f2def46fde385d4b9706a7a3d09

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Amino-3,5-Dicyanopyridines Targeting the Adenosine Receptors Ranging from Pan Ligands to Combined A1/A2B Partial Agonists

Autor: Katia Varani, Diego Dal Ben, Rosaria Volpini, Vittoria Colotta, Flavia Varano, Fabrizio Vincenzi, Silvia Pasquini, Daniela Catarzi

Publikováno v: Pharmaceuticals
Volume 12
Issue 4
Pharmaceuticals, Vol 12, Iss 4, p 159 (2019)

The amino-3,5-dicyanopyridine derivatives belong to an intriguing series of adenosine receptor (AR) ligands that has been developed by both academic researchers and industry. Indeed, the studies carried out to date underline the versatility of the di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59d75d1b87a1bba83d4fc89de674ba4a

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Modifications on the amino-3,5-dicyanopyridine core to obtain multifaceted adenosine receptor ligands with antineuropathic activity

Autor: Lorenzo Di Cesare Mannelli, Andrea Spinaci, Marta Menicatti, Elena Lucarini, Silvia Pasquini, Fabrizio Vincenzi, Marco Betti, Carla Ghelardini, Vittoria Colotta, Matteo Falsini, Flavia Varano, Gianluca Bartolucci, Daniela Catarzi, Diego Dal Ben, Katia Varani

A new series of amino-3,5-dicyanopyridines (1–31) was synthesized and biologically evaluated in order to further investigate the potential of this scaffold to obtain adenosine receptor (AR) ligands. In general, the modifications performed have led

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9734048283d01f42407fc9fb3ea0b1d0
http://hdl.handle.net/11581/428063

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