Divergent roles of DRY and NPxxY motifs in selective activation of downstream signalling by the apelin receptor.

Autor: Murali S; Department of Biotechnology, Bhupat and Jyoti Mehta School of Biological Sciences, Indian Institute of Technology Madras, Chennai, India., Aradhyam GK; Department of Biotechnology, Bhupat and Jyoti Mehta School of Biological Sciences, Indian Institute of Technology Madras, Chennai, India.

Publikováno v: The Biochemical journal [Biochem J] 2024 Dec 04; Vol. 481 (23), pp. 1707-1722.

Why is binding of a divalent metal cation to a structural motif containing four carboxylate residues not accompanied by a conformational change?

Autor: Lushchekina S; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel., Weiner L; Department of Brain Sciences, Weizmann Institute of Science, Rehovot, Israel.; Department of Chemical Research Support, Weizmann Institute of Science, Rehovot, Israel., Ashani Y; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel., Emrizal R; Department of Applied Physics, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, Bangi, Malaysia., Firdaus-Raih M; Department of Applied Physics, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, Bangi, Malaysia.; Institute of Systems Biology, Universiti Kebangsaan Malaysia, Bangi, Malaysia., Silman I; Department of Brain Sciences, Weizmann Institute of Science, Rehovot, Israel., Sussman JL; Department of Chemical and Structural Biology, Weizmann Institute of Science, Rehovot, Israel.; Structural Proteomics Unit, Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot, Israel.

Publikováno v: Protein science : a publication of the Protein Society [Protein Sci] 2024 Dec; Vol. 33 (12), pp. e5206.

The C-terminal amino acid motifs of NS1 protein affect the replication and virulence of naturally NS-truncated H1N1 canine influenza virus.

Autor: Wang P; Laboratory of Animal Infectious Diseases and Molecular Immunology, College of Animal Science and Technology, Guangxi University, Nanning, People's Republic of China.; Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics, Nanning, People's Republic of China.; Guangxi Key Laboratory of Animal Breeding, Disease Prevention and Control, Nanning, People's Republic of China., Guo J; Laboratory of Animal Infectious Diseases and Molecular Immunology, College of Animal Science and Technology, Guangxi University, Nanning, People's Republic of China., Zhou Y; Laboratory of Animal Infectious Diseases and Molecular Immunology, College of Animal Science and Technology, Guangxi University, Nanning, People's Republic of China.; Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics, Nanning, People's Republic of China.; Guangxi Key Laboratory of Animal Breeding, Disease Prevention and Control, Nanning, People's Republic of China., Zhu M; Laboratory of Animal Infectious Diseases and Molecular Immunology, College of Animal Science and Technology, Guangxi University, Nanning, People's Republic of China.; Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics, Nanning, People's Republic of China.; Guangxi Key Laboratory of Animal Breeding, Disease Prevention and Control, Nanning, People's Republic of China., Fang S; Department of Molecular Pharmacology, Tianjin Medical University Cancer Institute & Hospital, Tianjin, People's Republic of China.; National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin Clinical Research Center for Cancer, Tianjin, People's Republic of China., Sun F; Laboratory of Animal Infectious Diseases and Molecular Immunology, College of Animal Science and Technology, Guangxi University, Nanning, People's Republic of China.; Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics, Nanning, People's Republic of China.; Guangxi Key Laboratory of Animal Breeding, Disease Prevention and Control, Nanning, People's Republic of China., Huang C; Laboratory of Animal Infectious Diseases and Molecular Immunology, College of Animal Science and Technology, Guangxi University, Nanning, People's Republic of China.; Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics, Nanning, People's Republic of China.; Guangxi Key Laboratory of Animal Breeding, Disease Prevention and Control, Nanning, People's Republic of China., Zhu Y; Laboratory of Animal Infectious Diseases and Molecular Immunology, College of Animal Science and Technology, Guangxi University, Nanning, People's Republic of China.; Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics, Nanning, People's Republic of China.; Guangxi Key Laboratory of Animal Breeding, Disease Prevention and Control, Nanning, People's Republic of China., Zhou H; Huabo Pet Hospital, Nanning, People's Republic of China., Pan B; Department of Molecular Pharmacology, Tianjin Medical University Cancer Institute & Hospital, Tianjin, People's Republic of China.; National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin Clinical Research Center for Cancer, Tianjin, People's Republic of China., Qin Y; Laboratory of Animal Infectious Diseases and Molecular Immunology, College of Animal Science and Technology, Guangxi University, Nanning, People's Republic of China.; Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics, Nanning, People's Republic of China.; Guangxi Key Laboratory of Animal Breeding, Disease Prevention and Control, Nanning, People's Republic of China., Ouyang K; Laboratory of Animal Infectious Diseases and Molecular Immunology, College of Animal Science and Technology, Guangxi University, Nanning, People's Republic of China.; Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics, Nanning, People's Republic of China.; Guangxi Key Laboratory of Animal Breeding, Disease Prevention and Control, Nanning, People's Republic of China., Wei Z; Laboratory of Animal Infectious Diseases and Molecular Immunology, College of Animal Science and Technology, Guangxi University, Nanning, People's Republic of China.; Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics, Nanning, People's Republic of China.; Guangxi Key Laboratory of Animal Breeding, Disease Prevention and Control, Nanning, People's Republic of China., Huang W; Laboratory of Animal Infectious Diseases and Molecular Immunology, College of Animal Science and Technology, Guangxi University, Nanning, People's Republic of China.; Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics, Nanning, People's Republic of China.; Guangxi Key Laboratory of Animal Breeding, Disease Prevention and Control, Nanning, People's Republic of China., García-Sastre A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Chen Y; Laboratory of Animal Infectious Diseases and Molecular Immunology, College of Animal Science and Technology, Guangxi University, Nanning, People's Republic of China.; Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics, Nanning, People's Republic of China.; Guangxi Key Laboratory of Animal Breeding, Disease Prevention and Control, Nanning, People's Republic of China.

Publikováno v: Emerging microbes & infections [Emerg Microbes Infect] 2024 Dec; Vol. 13 (1), pp. 2400546. Date of Electronic Publication: 2024 Sep 13.

Dynamic fibrillar assembly of αB-crystallin induced by perturbation of the conserved NT-IXI motif resolved by cryo-EM.

Autor: McFarland R; Department of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, OR, USA.; Vollum Institute, Oregon Health & Science University, Portland, OR, USA.; Department of Chemistry, Portland State University, Portland, OR, USA.; Analytical and Formulation Sciences, KBI Biopharma, Boulder, CO, USA., Noroozi R; Department of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, OR, USA.; Vollum Institute, Oregon Health & Science University, Portland, OR, USA., Miller AP; Department of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, OR, USA.; Vollum Institute, Oregon Health & Science University, Portland, OR, USA., Reichow SL; Department of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, OR, USA. reichow@ohsu.edu.; Vollum Institute, Oregon Health & Science University, Portland, OR, USA. reichow@ohsu.edu.; Department of Chemistry, Portland State University, Portland, OR, USA. reichow@ohsu.edu.

Publikováno v: Nature communications [Nat Commun] 2024 Nov 28; Vol. 15 (1), pp. 10336. Date of Electronic Publication: 2024 Nov 28.

A conserved juxtamembrane motif in plant NFR5 receptors is essential for root nodule symbiosis.

Autor: Hansen SB; Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus C, Denmark., Luu TB; Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus C, Denmark., Gysel K; Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus C, Denmark., Lironi D; Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus C, Denmark., Krönauer C; Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus C, Denmark., Rübsam H; Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus C, Denmark., Jensen IB; Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus C, Denmark., Tsitsikli M; Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus C, Denmark., Birkefeldt TG; Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus C, Denmark., Trgovcevic A; Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus C, Denmark., Stougaard J; Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus C, Denmark., Radutoiu S; Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus C, Denmark., Andersen KR; Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus C, Denmark.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Nov 12; Vol. 121 (46), pp. e2405671121. Date of Electronic Publication: 2024 Nov 04.