Urea-Peptide Hybrids as VEGF-A165/NRP-1 Complex Inhibitors with Improved Receptor Affinity and Biological Properties

Autor: Anna K. Puszko, Piotr Sosnowski, Rachel Rignault-Bricard, Olivier Hermine, Gérard Hopfgartner, Karolina Pułka-Ziach, Yves Lepelletier, Aleksandra Misicka

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 1, p 72 (2020)

Neuropilin-1 (NRP-1), the major co-receptor of vascular endothelial growth factor receptor-2 (VEGFR-2), may also independently act with VEGF-A165 to stimulate tumour growth and metastasis. Therefore, there is great interest in compounds that can bloc

Externí odkaz: https://doaj.org/article/51173af837f44b1a9a9f4f019949ed6f

Urea moiety as amide bond mimetic in peptide-like inhibitors of VEGF-A165/NRP-1 complex

Autor: Olivier Hermine, Yves Lepelletier, Piotr Sosnowski, Karolina Pulka-Ziach, Aleksandra Misicka, Anna K. Puszko, Gérard Hopfgartner

Publikováno v: Bioorganic & Medicinal Chemistry Letters, Vol. 29, No 17 (2019) pp. 2493-2497

NRP-1 is an important co-receptor of vascular endothelial growth factor receptor-2 (VEGFR-2). Many reports suggested that NRP-1 might also serve as a separate receptor for VEGF-A165 causing stimulation of tumour growth and metastasis. Therefore, comp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f74744b51cadc712afec79f47de9a37
https://archive-ouverte.unige.ch/unige:142029

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Urea-Peptide Hybrids as VEGF-A 165 /NRP-1 Complex Inhibitors with Improved Receptor Affinity and Biological Properties.

Autor: Puszko AK; Faculty of Chemistry, University of Warsaw, Pasteura 1, 02-093 Warsaw, Poland., Sosnowski P; Department of Inorganic and Analytical Chemistry, University of Geneva, 24 Quai Ernest Ansermet, CH-1211 Geneva, Switzerland., Rignault-Bricard R; Imagine Institute, Université de Paris, 24 boulevard Montparnasse, 75015 Paris, France.; INSERM UMR 1163, Laboratory of Cellular and Molecular Basis of Normal Hematopoiesis and Hematological Disorders: Therapeutical Implications, 24 Boulevard Montparnasse, 75015 Paris, France., Hermine O; Imagine Institute, Université de Paris, 24 boulevard Montparnasse, 75015 Paris, France.; INSERM UMR 1163, Laboratory of Cellular and Molecular Basis of Normal Hematopoiesis and Hematological Disorders: Therapeutical Implications, 24 Boulevard Montparnasse, 75015 Paris, France., Hopfgartner G; Department of Inorganic and Analytical Chemistry, University of Geneva, 24 Quai Ernest Ansermet, CH-1211 Geneva, Switzerland., Pułka-Ziach K; Faculty of Chemistry, University of Warsaw, Pasteura 1, 02-093 Warsaw, Poland., Lepelletier Y; Imagine Institute, Université de Paris, 24 boulevard Montparnasse, 75015 Paris, France.; INSERM UMR 1163, Laboratory of Cellular and Molecular Basis of Normal Hematopoiesis and Hematological Disorders: Therapeutical Implications, 24 Boulevard Montparnasse, 75015 Paris, France., Misicka A; Faculty of Chemistry, University of Warsaw, Pasteura 1, 02-093 Warsaw, Poland.; Department of Neuropeptides, Mossakowski Medical Research Centre, Polish Academy of Sciences, Pawinskiego 5, 02-106 Warsaw, Poland.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2020 Dec 23; Vol. 22 (1). Date of Electronic Publication: 2020 Dec 23.