Zobrazeno 1 - 10
of 420
pro vyhledávání: '"alzheimer disease(ad)"'
Cheminformatics-driven prediction of BACE-1 inhibitors: Affinity and molecular mechanism exploration
Autor:
Rahul D. Jawarkar, Anam Khan, Suraj N. Mali, Prashant K. Deshmukh, Rahul G. Ingle, Sami A Al-Hussain, Aamal A. Al-Mutairi, Magdi E.A. Zaki
Publikováno v:
Chemical Physics Impact, Vol 9, Iss , Pp 100754- (2024)
The β-secretase, sometimes referred to as BACE1 or Asp2, is the enzyme responsible for initiating the production of Aβ by breaking down the amyloid precursor protein. Hence, BACE is a pivotal target for pharmacological intervention aimed at diminis
Externí odkaz:
https://doaj.org/article/cc8089ba751b4a77b9d27d58ce3e9549
Publikováno v:
The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, Vol 59, Iss 1, Pp 1-14 (2023)
Abstract Alzheimer’s disease (AD) is a form of dementia marked by the accumulation of neuritic plaques and neurofibrillary tangles through the action of GSK-3β with both significant epidemiological and clinical impact. Current pharmacological trea
Externí odkaz:
https://doaj.org/article/ff5ecfc9febb4a438796e253b875e9de
Autor:
Farzaneh Ahmadi, Saleh Behzadi, Komeil Aghazadeh-Habashi, Kimia Eyvani, Anita Fatehi, Milad Alipour, Fatemeh Sodeifian, Faraz Rahmani Khajeh, AmirMahdi AzariBakhsh, Amirhossein Nazerian, Arian Tavasol, Andis Klegeris, Alyssa McElhinney, Nader Markazi-moghaddam, Mohammad Fathi, Mohammadreza Hajiesmaeili, Navid Nooraei
Publikováno v:
Caspian Journal of Neurological Sciences, Vol 10, Iss 3 (2024)
Background: Alterations in the kynurenine pathway (KP) metabolite can contribute to the pathogenesis and progression of many psychiatric and neurodegenerative illnesses, including Alzheimer disease (AD) and Huntington disease (HD), primarily through
Externí odkaz:
https://doaj.org/article/878e255bf68e4369b1d6867640f7156f
Autor:
Sujey Palma-Florez, Adrián López-Canosa, Francisco Moralez-Zavala, Oscar Castaño, Marcelo J. Kogan, Josep Samitier, Anna Lagunas, Mònica Mir
Publikováno v:
Journal of Nanobiotechnology, Vol 21, Iss 1, Pp 1-17 (2023)
Abstract Background The lack of predictive models that mimic the blood–brain barrier (BBB) hinders the development of effective drugs for neurodegenerative diseases. Animal models behave differently from humans, are expensive and have ethical const
Externí odkaz:
https://doaj.org/article/57ada41526b44f1c9d37a22133a15cda
Akademický článek
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Autor:
Yelei Zhang, Xiaoyue Li, Yu Hu, Hongwei Yuan, Xiaodong Wu, Yating Yang, Tongtong Zhao, Ke Hu, Zhiqiang Wang, Guoqiang Wang, Kai Zhang, Huanzhong Liu
Publikováno v:
BMC Psychiatry, Vol 22, Iss 1, Pp 1-11 (2022)
Abstract Background Mild cognitive impairment (MCI) is a kind of non-functional cognitive decline between normal aging and dementia. With the increase of individual age, the quality of cognitive function has become a more and more important topic. Th
Externí odkaz:
https://doaj.org/article/1fe0d6e6497e40f88d360144a1efbacb
Publikováno v:
IEEE Access, Vol 10, Pp 66511-66521 (2022)
Dementia is a term used to describe a variety of symptoms related to cognitive impairment in which Alzheimer disease represents 60% – 70% of the cases. As of today, there is no cure for this disease and the only way to prevent any associated medica
Externí odkaz:
https://doaj.org/article/270bec9dd5a94d9595a3c42899abe62d
Akademický článek
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Akademický článek
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Autor:
Bijen Khagi, Goo-Rak Kwon
Publikováno v:
JOIV: International Journal on Informatics Visualization, Vol 5, Iss 2, Pp 200-205 (2021)
A recent study from MRI has revealed that there is a minor increase in cerebral-spinal fluid (CSF) content in brain ventricles and sulci, along with a substantial decrease in grey matter (GM) content and brain volume among Alzheimer's disease (AD) pa
Externí odkaz:
https://doaj.org/article/3b1e65456a7c4ad2bfeb7dcc52ea933a