Zobrazeno 1 - 10
of 462
pro vyhledávání: '"alternative promoters"'
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Most human genes code for more than one transcript. Different ratios of transcripts of the same gene can be found in different cell types or states, indicating differential use of transcription start sites or differential splicing. Such differential
Externí odkaz:
https://doaj.org/article/a3f3863c3c25450e9f279455ce65ba0c
Autor:
Yuting Dong, Xiaozhao Liu, Bijun Jiang, Siting Wei, Bangde Xiang, Ruichu Liao, Qiuyan Wang, Ximiao He
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Externí odkaz:
https://doaj.org/article/a83d8f49ad8d411489a66d3ab5ea293e
Autor:
Elisa Le Boiteux, Franck Court, Pierre‐Olivier Guichet, Catherine Vaurs‐Barrière, Isabelle Vaillant, Emmanuel Chautard, Pierre Verrelle, Bruno M. Costa, Lucie Karayan‐Tapon, Anne Fogli, Philippe Arnaud
Publikováno v:
Molecular Oncology, Vol 15, Iss 8, Pp 1995-2010 (2021)
In human, the 39 coding HOX genes and 18 referenced noncoding antisense transcripts are arranged in four genomic clusters named HOXA, B, C, and D. This highly conserved family belongs to the homeobox class of genes that encode transcription factors r
Externí odkaz:
https://doaj.org/article/fed95548f2564556b60979aca372b0ee
Autor:
Yuting Dong, Xiaozhao Liu, Bijun Jiang, Siting Wei, Bangde Xiang, Ruichu Liao, Qiuyan Wang, Ximiao He
Publikováno v:
Frontiers in Oncology, Vol 11 (2022)
BackgroundThe alternative usage of promoters provides a way to regulate gene expression, has a significant influence on the transcriptome, and contributes to the cellular transformation of cancer. However, the function of alternative promoters (APs)
Externí odkaz:
https://doaj.org/article/a0f4d27084534ea4bcbf87c34d790bae
Autor:
Sonia Casanovas, Laura Schlichtholz, Sophia Mühlbauer, Sri Dewi, Martin Schüle, Dennis Strand, Susanne Strand, Lea Zografidou, Jennifer Winter
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
The RNA-binding protein RBFOX1 is an important regulator of neuron development and neuronal excitability. Rbfox1 is a dosage-sensitive gene and in both mice and humans, decreased expression of Rbfox1 has been linked to neurodevelopmental disorders. A
Externí odkaz:
https://doaj.org/article/66ee41d01c884b09bd65dd146f37821f
Akademický článek
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Publikováno v:
G3: Genes, Genomes, Genetics, Vol 7, Iss 8, Pp 2577-2593 (2017)
Several genes that have been implicated in autism spectrum disorders (ASDs) have multiple transcripts. Therefore, comprehensive transcript annotation is critical for determining the respective gene function. The autism susceptibility candidate 2 (AUT
Externí odkaz:
https://doaj.org/article/8feee772ba7b448b90815cff0671c04b
Autor:
Peter Zhang, Emmanuel Dimont, Thomas Ha, Douglas J. Swanson, the FANTOM Consortium, Winston Hide, Dan Goldowitz
Publikováno v:
BMC Genomics, Vol 18, Iss 1, Pp 1-14 (2017)
Abstract Background Alternative transcription start site (TSS) usage plays important roles in transcriptional control of mammalian gene expression. The growing interest in alternative TSSs and their role in genome diversification spawned many single-
Externí odkaz:
https://doaj.org/article/d67530689a794bd8b92cc0bb25559cbb
Autor:
V. K. Chaithanya Ponnaluri, Kenneth C. Ehrlich, Guoqiang Zhang, Michelle Lacey, Douglas Johnston, Sriharsa Pradhan, Melanie Ehrlich
Publikováno v:
Epigenetics, Vol 12, Iss 2, Pp 123-138 (2017)
Differentially methylated or hydroxymethylated regions (DMRs) in mammalian DNA are often associated with tissue-specific gene expression but the functional relationships are still being unraveled. To elucidate these relationships, we studied 16 human
Externí odkaz:
https://doaj.org/article/b661daf998f643bcb9d69f00ecb90e1b
Autor:
Hong Lou, Hongchuan Li, Kevin J. Ho, Luke L. Cai, Andy S. Huang, Tyler R. Shank, Michael R. Verneris, Michael L. Nickerson, Michael Dean, Stephen K. Anderson
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 7 (2019)
Tet methylcytosine dioxygenase 2 (TET2) is a tumor suppressor gene that is inactivated in a wide range of hematological cancers. TET2 enzymatic activity converts 5-methylcytosine (5-mC) into 5-hydroxymethylcytosine (5-hmC), an essential step in DNA d
Externí odkaz:
https://doaj.org/article/96b99fbd34af4bcb9e2300a3abdfafad