Zobrazeno 1 - 10
of 1 486
pro vyhledávání: '"alphafold"'
Autor:
Stephanie Penning, Yaoqin Hong, Taylor Cunliffe, Lilian Hor, Makrina Totsika, Jason J. Paxman, Begoña Heras
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 4324-4336 (2024)
In bacteria the formation of disulphide bonds is facilitated by a family of enzymes known as the disulphide bond forming (Dsb) proteins, which, despite low sequence homology, belong to the thioredoxin (TRX) superfamily. Among these enzymes is the dis
Externí odkaz:
https://doaj.org/article/bf1643b7e99a401dbd9ad7081d106ecf
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 2938-2948 (2024)
Cellular immunity relies on the ability of a T-cell receptor (TCR) to recognize a peptide (p) presented by a class I major histocompatibility complex (MHC) receptor on the surface of a cell. The TCR-peptide-MHC (TCRpMHC) interaction is a crucial step
Externí odkaz:
https://doaj.org/article/00e80ae8f8b84ec4aa60c524d07e52e5
Autor:
Wenxing Hu, Masahito Ohue
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 1214-1225 (2024)
Rapid advancements in protein sequencing technology have resulted in gaps between proteins with identified sequences and those with mapped structures. Although sequence-based predictions offer insights, they can be incomplete due to the absence of st
Externí odkaz:
https://doaj.org/article/88280cb7ec0e408198c39d55acc062a9
Autor:
Karina Kapusta, Allyson McGowan, Santanu Banerjee, Jing Wang, Wojciech Kolodziejczyk, Jerzy Leszczynski
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 11, Pp 12550-12573 (2024)
Even though COVID-19 is no longer the primary focus of the global scientific community, its high mutation rate (nearly 30 substitutions per year) poses a threat of a potential comeback. Effective vaccines have been developed and administered to the p
Externí odkaz:
https://doaj.org/article/060bccc42385407d9935c0e62bd93a54
Autor:
Alasdair I. MacDonald, Aron Baksh, Alexandria Holland, Heewhan Shin, Phoebe A. Rice, W. Marshall Stark, Femi J. Olorunniji
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Serine integrases are phage- (or mobile element-) encoded enzymes that catalyse site-specific recombination reactions between a short DNA sequence on the phage genome (attP) and a corresponding host genome sequence (attB), thereby integratin
Externí odkaz:
https://doaj.org/article/73b6640b58ef469a864e4d5cbc87a337
Autor:
Song-Bin Guo, Yuan Meng, Liteng Lin, Zhen-Zhong Zhou, Hai-Long Li, Xiao-Peng Tian, Wei-Juan Huang
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-7 (2024)
Abstract AlphaFold model has reshaped biological research. However, vast unstructured data in the entire AlphaFold field requires further analysis to fully understand the current research landscape and guide future exploration. Thus, this scientometr
Externí odkaz:
https://doaj.org/article/fae61694b41440d49ed9c053e526316a
Autor:
Henrietta Onyinye Uzoeto, Samuel Cosmas, Toluwalope Temitope Bakare, Olanrewaju Ayodeji Durojaye
Publikováno v:
Beni-Suef University Journal of Basic and Applied Sciences, Vol 13, Iss 1, Pp 1-5 (2024)
Abstract Breakthrough achievements in protein structure prediction have occurred recently, mostly due to the advent of sophisticated machine learning methods and significant advancements in algorithmic approaches. The most recent version of the Alpha
Externí odkaz:
https://doaj.org/article/116c454140824ac8bf37d8d489e44d1d
Autor:
Erin R. Butterfield, Samson O. Obado, Simon R. Scutts, Wenzhu Zhang, Brian T. Chait, Michael P. Rout, Mark C. Field
Publikováno v:
Nucleus, Vol 15, Iss 1 (2024)
The nuclear envelope (NE) separates translation and transcription and is the location of multiple functions, including chromatin organization and nucleocytoplasmic transport. The molecular basis for many of these functions have diverged between eukar
Externí odkaz:
https://doaj.org/article/ae18073f1f5e4692a04948d564b2452b
Autor:
Phuong Tran Nguyen, Brandon John Harris, Diego Lopez Mateos, Adriana Hernández González, Adam Michael Murray, Vladimir Yarov-Yarovoy
Publikováno v:
Channels, Vol 18, Iss 1 (2024)
Ion channels play key roles in human physiology and are important targets in drug discovery. The atomic-scale structures of ion channels provide invaluable insights into a fundamental understanding of the molecular mechanisms of channel gating and mo
Externí odkaz:
https://doaj.org/article/beab5ea70fd84c6f9e25b028bb4eafa2
Autor:
Véronique Megalizzi, Abdalkarim Tanina, Camille Grosse, Manon Mirgaux, Pierre Legrand, Gaëtan Dias Mirandela, Alexandre Wohlkönig, Pablo Bifani, René Wintjens
Publikováno v:
Heliyon, Vol 10, Iss 22, Pp e40494- (2024)
MabR (Rv2242), a PucR-type transcription factor, plays a crucial role in regulating mycolic acid biosynthesis in Mycobacterium tuberculosis. To understand its regulatory mechanisms, we determined the crystal structures of its N-terminal and C-termina
Externí odkaz:
https://doaj.org/article/439bd49e186942b88d4665f0fff4e6f4