Zobrazeno 1 - 10
of 960
pro vyhledávání: '"alpha-synuclein (αSyn)"'
Autor:
Petricca, Lara1 (AUTHOR), Chiki, Nour1 (AUTHOR), Hanna-El-Daher, Layane2 (AUTHOR), Aeschbach, Lorène2 (AUTHOR), Burai, Ritwik2 (AUTHOR), Stoops, Erik3 (AUTHOR), Fares, Mohamed-Bilal1 (AUTHOR), Lashuel, Hilal A.1,2 (AUTHOR) hilal.lashuel@epfl.ch
Publikováno v:
Journal of Parkinson's Disease. 2022, Vol. 12 Issue 5, p1449-1462. 14p.
Autor:
Barbuti, Peter A.1 (AUTHOR) pab2184@cumc.columbia.edu
Publikováno v:
International Journal of Molecular Sciences. Jun2024, Vol. 25 Issue 12, p6525. 26p.
Autor:
Lara Petricca, Nour Chiki, Layane Hanna-El-Daher, Lorène Aeschbach, Ritwik Burai, Erik Stoops, Mohamed-Bilal Fares, Hilal A. Lashuel
Publikováno v:
Journal of Parkinson's Disease. 12:1449-1462
BackgroundThe development of therapeutics for Parkinson’s disease (PD) requires the establishment of biomarker assays to enable stratifying patients, monitoring disease progression and assessing target engagement. Attempts to develop diagnostic ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::077ad9ff72550be1fbb1035981b8f36e
https://doi.org/10.3233/jpd-223285
https://doi.org/10.3233/jpd-223285
Autor:
Peter A. Barbuti
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 12, p 6525 (2024)
Parkinson’s disease (PD) is a disease of an unknown origin. Despite that, decades of research have provided considerable evidence that alpha-synuclein (αSyn) is central to the pathogenesis of disease. Mitochondria-associated endoplasmic reticulum
Externí odkaz:
https://doaj.org/article/f2b7a8cce22e45239d97ab5bccd70e34
Autor:
Inga Petersen, Muhammad Ilyas Ali, Alex Petrovic, Anders Jimmy Ytterberg, Karin Staxäng, Monika Hodik, Fadi Rofo, Sina Bondza, Greta Hultqvist
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTSoluble aggregates are reported to be the most neurotoxic species of α-Synuclein (αSyn) in Parkinson’s disease (PD) and hence are a promising target for diagnosis and treatment of PD. However, the predominantly intracellular location of
Externí odkaz:
https://doaj.org/article/fce9db4fa4384fd3ad0fdb528d47e125
Autor:
Roshanbin, Sahar1 (AUTHOR) sahar.roshanbin@pubcare.uu.se, Julku, Ulrika1 (AUTHOR) mengfei.xiong@pubcare.uu.se, Xiong, Mengfei1 (AUTHOR) joakim.bergstrom@pubcare.uu.se, Eriksson, Jonas2,3 (AUTHOR) jonas.p.eriksson@akademiska.se, Masliah, Eliezer4 (AUTHOR) eliezer.masliah@nih.gov, Hultqvist, Greta5 (AUTHOR) greta.hultqvist@farmaci.uu.se, Bergström, Joakim1 (AUTHOR) martin.ingelsson@pubcare.uu.se, Ingelsson, Martin1,6,7 (AUTHOR) stina.syvanen@pubcare.uu.se, Syvänen, Stina1 (AUTHOR), Sehlin, Dag1 (AUTHOR) sahar.roshanbin@pubcare.uu.se
Publikováno v:
Pharmaceutics. Jul2022, Vol. 14 Issue 7, pN.PAG-N.PAG. 16p.
Autor:
Sara J. Fagen, Jeremy D. Burgess, Melina J. Lim, Danilyn Amerna, Zeynep B. Kaya, Ayman H. Faroqi, Priyanka Perisetla, Natasha N. DeMeo, Iva Stojkovska, Drew J. Quiriconi, Joseph R. Mazzulli, Marion Delenclos, Suelen L. Boschen, Pamela J. McLean
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
BackgroundIntracytoplasmic inclusions comprised of aggregated alpha-synuclein (αsyn) represent a key histopathological feature of neurological disorders collectively termed “synucleinopathies,” which includes Parkinson’s disease (PD). Mutation
Externí odkaz:
https://doaj.org/article/2969623c54014de0ac6153319e52265f
Publikováno v:
Scripta Score Scientific Medical Journal, Vol 3, Iss 1, Pp 76-83 (2021)
Background: Parkinson's Disease (PD) is one of the most common neurodegenerative diseases at the age of 40-70 years. Disorders of the Gut-Microbiota-Brain Axis have been linked to bacterial metabolite products that play a role in the occurrence of ne
Externí odkaz:
https://doaj.org/article/9ce348b5284146cdbec01d79b5d6d4a0
Autor:
Ivanova, Olga1 (AUTHOR) olga.ivanova@insysbio.com, Karelina, Tatiana1 (AUTHOR)
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology. Oct2024, Vol. 13 Issue 10, p1798-1809. 12p.
Autor:
Sorrentino, Zachary A.1,2 (AUTHOR) Zachary.Sorrentino@neurosurgery.ufl.edu, Riklan, Joshua1 (AUTHOR), Lloyd, Grace M.1,3 (AUTHOR), Lucke-Wold, Brandon P.1,2 (AUTHOR), Mampre, David1,2 (AUTHOR), Quintin, Stephan1,3 (AUTHOR), Zakare-Fagbamila, Rasheedat1,2 (AUTHOR), Still, Megan1,2 (AUTHOR), Chandra, Vyshak1,2 (AUTHOR), Foote, Kelly D.1,2 (AUTHOR), Giasson, Benoit I.1,3 (AUTHOR), Hilliard, Justin D.1,2 (AUTHOR)
Publikováno v:
Scientific Reports. 9/16/2024, Vol. 14 Issue 1, p1-12. 12p.