Regulation of human interferon signaling by transposon exonization.

Autor: Pasquesi GIM; BioFrontiers Institute and Department of Molecular, Cellular & Developmental Biology, University of Colorado Boulder, Boulder, CO 80309, USA; Crnic Institute Boulder Branch, BioFrontiers Institute, University of Colorado Boulder, Boulder, CO 80303, USA., Allen H; BioFrontiers Institute and Department of Molecular, Cellular & Developmental Biology, University of Colorado Boulder, Boulder, CO 80309, USA., Ivancevic A; BioFrontiers Institute and Department of Molecular, Cellular & Developmental Biology, University of Colorado Boulder, Boulder, CO 80309, USA., Barbachano-Guerrero A; BioFrontiers Institute and Department of Molecular, Cellular & Developmental Biology, University of Colorado Boulder, Boulder, CO 80309, USA., Joyner O; BioFrontiers Institute and Department of Molecular, Cellular & Developmental Biology, University of Colorado Boulder, Boulder, CO 80309, USA., Guo K; Division of Infectious Diseases, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA., Simpson DM; BioFrontiers Institute and Department of Molecular, Cellular & Developmental Biology, University of Colorado Boulder, Boulder, CO 80309, USA., Gapin K; BioFrontiers Institute and Department of Molecular, Cellular & Developmental Biology, University of Colorado Boulder, Boulder, CO 80309, USA., Horton I; BioFrontiers Institute and Department of Molecular, Cellular & Developmental Biology, University of Colorado Boulder, Boulder, CO 80309, USA., Nguyen LL; BioFrontiers Institute and Department of Molecular, Cellular & Developmental Biology, University of Colorado Boulder, Boulder, CO 80309, USA; Division of Reproductive Sciences, Department of Obstetrics and Gynecology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA., Yang Q; BioFrontiers Institute and Department of Molecular, Cellular & Developmental Biology, University of Colorado Boulder, Boulder, CO 80309, USA; Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA., Warren CJ; BioFrontiers Institute and Department of Molecular, Cellular & Developmental Biology, University of Colorado Boulder, Boulder, CO 80309, USA; The Ohio State University College of Veterinary Medicine, Columbus, OH 43210, USA., Florea LD; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Bitler BG; Division of Reproductive Sciences, Department of Obstetrics and Gynecology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA., Santiago ML; Division of Infectious Diseases, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA., Sawyer SL; BioFrontiers Institute and Department of Molecular, Cellular & Developmental Biology, University of Colorado Boulder, Boulder, CO 80309, USA., Chuong EB; BioFrontiers Institute and Department of Molecular, Cellular & Developmental Biology, University of Colorado Boulder, Boulder, CO 80309, USA; Crnic Institute Boulder Branch, BioFrontiers Institute, University of Colorado Boulder, Boulder, CO 80303, USA. Electronic address: edward.chuong@colorado.edu.

Publikováno v: Cell [Cell] 2024 Dec 26; Vol. 187 (26), pp. 7621-7636.e19. Date of Electronic Publication: 2024 Dec 12.

Promiscuous Janus kinase binding to cytokine receptors modulates signaling efficiencies and contributes to cytokine pleiotropy.

Autor: Zoler E; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel., Meyer T; Department of Biology/Chemistry and Center for Cellular Nanoanalytics, Osnabrück University, Osnabrück, Germany., Bellón JS; Department of Biology/Chemistry and Center for Cellular Nanoanalytics, Osnabrück University, Osnabrück, Germany., Mönnig M; Department of Biology/Chemistry and Center for Cellular Nanoanalytics, Osnabrück University, Osnabrück, Germany., Sun B; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel., Piehler J; Department of Biology/Chemistry and Center for Cellular Nanoanalytics, Osnabrück University, Osnabrück, Germany., Schreiber G; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.

Publikováno v: Science signaling [Sci Signal] 2024 Nov 19; Vol. 17 (863), pp. eadl1892. Date of Electronic Publication: 2024 Nov 19.

Adjusting susceptibilities of C57BL/6 mice to orthoflaviviruses for evaluation of antiviral drugs by altering the levels of interferon alpha/beta receptor function.

Autor: Morrey JD; Institute for Antiviral Research, Utah State University, 5600 Old Main Hill, Logan, UT 84321-5600, USA. Electronic address: john.morrey@usu.edu., Siddharthan V; Institute for Antiviral Research, Utah State University, 5600 Old Main Hill, Logan, UT 84321-5600, USA.

Publikováno v: Journal of virological methods [J Virol Methods] 2025 Jan; Vol. 331, pp. 115053. Date of Electronic Publication: 2024 Oct 18.

Vaccine candidates based on MVA viral vectors expressing VP2 or VP7 confer full protection against Epizootic hemorrhagic disease virus in IFNAR(-/-) mice.

Autor: Jiménez-Cabello L; Centro de Investigación en Sanidad Animal (CISA), Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Valdeolmos, Madrid, Spain., Utrilla-Trigo S; Centro de Investigación en Sanidad Animal (CISA), Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Valdeolmos, Madrid, Spain., Rodríguez-Sabando K; Centro de Investigación en Sanidad Animal (CISA), Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Valdeolmos, Madrid, Spain., Carra-Valenzuela A; Centro de Investigación en Sanidad Animal (CISA), Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Valdeolmos, Madrid, Spain., Illescas-Amo M; Centro de Investigación en Sanidad Animal (CISA), Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Valdeolmos, Madrid, Spain., Calvo-Pinilla E; Centro de Investigación en Sanidad Animal (CISA), Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Valdeolmos, Madrid, Spain., Ortego J; Centro de Investigación en Sanidad Animal (CISA), Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Valdeolmos, Madrid, Spain.

Publikováno v: Journal of virology [J Virol] 2024 Dec 17; Vol. 98 (12), pp. e0168724. Date of Electronic Publication: 2024 Nov 07.

A common form of dominant human IFNAR1 deficiency impairs IFN-α and -ω but not IFN-β-dependent immunity.

Autor: Al Qureshah F; St Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA.; Wellness and Preventive Medicine Institute, King Abdulaziz City for Science and Technology , Riyadh, Saudi Arabia., Le Pen J; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA., de Weerd NA; Centre for Innate Immunity and Infectious Diseases, Department of Molecular and Translational Science, Hudson Institute of Medical Research and Monash University, Clayton, Australia., Moncada-Velez M; St Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA., Materna M; Laboratory of Human Genetics of Infectious Diseases, INSERM U1163, Necker Hospital for Sick Children, Paris, France.; Université Paris Cité, Imagine Institute , Paris, France., Lin DC; St Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA.; Université Paris Cité, Imagine Institute , Paris, France., Milisavljevic B; St Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA., Vianna F; Laboratório de Medicina Genômica Centro de Pesquisa Experimental, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.; Graduate Program in Genetics and Molecular Biology, Federal University of Rio Grande do Sul , Porto Alegre, Brazil.; Graduate Program in Medicine, Medical Sciences, Federal University of Rio Grande do Sul , Porto Alegre, Brazil.; National Institute of Population Medical Genetics (INAGEMP) , Porto Alegre, Brazil., Bizien L; Laboratory of Human Genetics of Infectious Diseases, INSERM U1163, Necker Hospital for Sick Children, Paris, France.; Université Paris Cité, Imagine Institute , Paris, France., Lorenzo L; Laboratory of Human Genetics of Infectious Diseases, INSERM U1163, Necker Hospital for Sick Children, Paris, France.; Université Paris Cité, Imagine Institute , Paris, France., Lecuit M; Université Paris Cité, Imagine Institute , Paris, France.; Department of Infectious Diseases and Tropical Medicine, Necker-Enfants Malades University Hospital, APHP, Institut Imagine, Paris, France.; Biology of Infection Unit, Institut Pasteur, Inserm U1117, Université Paris Cité, Paris, France., Pommier JD; Biology of Infection Unit, Institut Pasteur, Inserm U1117, Université Paris Cité, Paris, France., Keles S; Division of Pediatric Allergy and Immunology, Meram Medical Faculty, Necmettin Erbakan University, Konya, Turkey., Ozcelik T; Department of Molecular Biology and Genetics, Bilkent University, Bilkent-Ankara, Turkey., Pedraza-Sanchez S; Unit of Biochemistry, National Institute for Medical Sciences and Nutrition Salvador Zubiran (INCMNSZ) , Mexico City, Mexico., de Prost N; Service de Médecine Intensive Réanimation, Hôpitaux Universitaires Henri Mondor, Assistance Publique-Hôpitaux de Paris (AP-HP) , Paris, France.; Groupe de Recherche Clinique CARMAS, Faculté de Santé de Créteil, Université Paris Est Créteil , Créteil Cedex, France.; INSERM U955, Team 'Viruses, Hepatology, Cancer' , Créteil, France., El Zein L; Biology Department, Lebanese University, Beirut, Lebanon., Hammoud H; Saint Georges Hospital , Beirut, Lebanon., Ng LFP; A*STAR Infectious Disease Labs, Agency for Science, Technology and Research , Singapore, Singapore.; Lee Kong Chian School of Medicine, Nanyang Technology University , Singapore, Singapore., Halwani R; Research Institute for Medical and Health Sciences, University of Sharjah , Sharjah, UAE.; Prince Abdullah Bin Khalid Celiac Disease Research Chair, Department of Pediatrics, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia., Saheb Sharif-Askari N; Research Institute for Medical and Health Sciences, University of Sharjah , Sharjah, UAE., Lau YL; Department of Pediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong, China., Tam AR; Division of Infectious Diseases, Department of Medicine, School of Clinical Medicine, University of Hong Kong, Hong Kong, China., Singh N; ASTER CMI Hospitals , Bengaluru, India., Bhattad S; ASTER CMI Hospitals , Bengaluru, India., Berkun Y; Department of Pediatrics, Hadassah-Hebrew University Medical Center, Mount Scopus and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel., Chantratita W; Center for Medical Genomics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand., Aguilar-López R; Department of Surgery, Maternal and Child Hospital, Social Security Institute of the State of Mexico and Municipalities (ISSEMYM), Toluca, Mexico., Shahrooei M; Clinical and Diagnostic Immunology, Department of Microbiology, Immunology, and Transplantation, KU Leuven, Leuven, Belgium.; Dr. Shahrooei's Laboratory , Tehran, Iran., Abel L; St Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA.; Laboratory of Human Genetics of Infectious Diseases, INSERM U1163, Necker Hospital for Sick Children, Paris, France.; Université Paris Cité, Imagine Institute , Paris, France., Bastard P; St Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA.; Laboratory of Human Genetics of Infectious Diseases, INSERM U1163, Necker Hospital for Sick Children, Paris, France.; Université Paris Cité, Imagine Institute , Paris, France.; Pediatric Hematology-Immunology and Rheumatology Unit, Necker Hospital for Sick Children, Assistance Publique-Hôpitaux de Paris , Paris, France., Jouanguy E; St Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA.; Laboratory of Human Genetics of Infectious Diseases, INSERM U1163, Necker Hospital for Sick Children, Paris, France.; Université Paris Cité, Imagine Institute , Paris, France., Béziat V; St Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA.; Laboratory of Human Genetics of Infectious Diseases, INSERM U1163, Necker Hospital for Sick Children, Paris, France.; Université Paris Cité, Imagine Institute , Paris, France., Zhang P; St Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA.; Laboratory of Human Genetics of Infectious Diseases, INSERM U1163, Necker Hospital for Sick Children, Paris, France.; Université Paris Cité, Imagine Institute , Paris, France., Rice CM; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA., Cobat A; St Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA.; Laboratory of Human Genetics of Infectious Diseases, INSERM U1163, Necker Hospital for Sick Children, Paris, France.; Université Paris Cité, Imagine Institute , Paris, France., Zhang SY; St Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA.; Laboratory of Human Genetics of Infectious Diseases, INSERM U1163, Necker Hospital for Sick Children, Paris, France.; Université Paris Cité, Imagine Institute , Paris, France., Hertzog PJ; Centre for Innate Immunity and Infectious Diseases, Department of Molecular and Translational Science, Hudson Institute of Medical Research and Monash University, Clayton, Australia., Casanova JL; St Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA.; Laboratory of Human Genetics of Infectious Diseases, INSERM U1163, Necker Hospital for Sick Children, Paris, France.; Université Paris Cité, Imagine Institute , Paris, France.; Howard Hughes Medical Institute , New York, NY, USA.; Department of Pediatrics, Necker Hospital for Sick Children, Paris, France., Zhang Q; St Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA.; Laboratory of Human Genetics of Infectious Diseases, INSERM U1163, Necker Hospital for Sick Children, Paris, France.; Université Paris Cité, Imagine Institute , Paris, France.

Publikováno v: The Journal of experimental medicine [J Exp Med] 2025 Feb 03; Vol. 222 (2). Date of Electronic Publication: 2024 Dec 16.