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Role of Hepatocyte Senescence in the Activation of Hepatic Stellate Cells and Liver Fibrosis Progression

Autor: Pramudi Wijayasiri, Stuart Astbury, Philip Kaye, Fiona Oakley, Graeme J. Alexander, Timothy J. Kendall, Aloysious D. Aravinthan

Publikováno v: Cells, Vol 11, Iss 14, p 2221 (2022)

Hepatocyte senescence is associated with liver fibrosis. However, the possibility of a direct, causal relation between hepatocyte senescence and hepatic stellate cell (HSC) activation was the subject of this study. Liver biopsy specimens obtained fro

Externí odkaz: https://doaj.org/article/3960200758914060ae2e9bf2b3c7c4a8

Expanding the genetic and phenotypic spectrum of ACTA2-related vasculopathies in a Dutch cohort

Autor: Lisa M. van den Bersselaar, Judith M.A. Verhagen, Jos A. Bekkers, Marlies Kempers, Arjan C. Houweling, Marieke Baars, Eline Overwater, Yvonne Hilhorst-Hofstee, Daniela Q.C.M. Barge-Schaapveld, Eline Rompen, Ingrid P.C. Krapels, Eelco Dulfer, Marja W. Wessels, Bart L. Loeys, Hence J.M. Verhagen, Alessandra Maugeri, Jolien W. Roos-Hesselink, Hennie T. Brüggenwirth, Ingrid M.B.H. van de Laar

Publikováno v: Genetics in medicine
Genetics in Medicine, 24(10), 2112-2122. Lippincott Williams and Wilkins
Genetics in Medicine, 24, 2112-2122
Genetics in Medicine, 24(10), 2112-2122. Nature Publishing Group
Genetics in Medicine, 24(10), 2112-2122. ELSEVIER SCIENCE INC
Genetics in Medicine, 24(10), 2112-2122. Lippincott Williams & Wilkins
Genetics in Medicine, 24, 10, pp. 2112-2122
van den Bersselaar, L M, Verhagen, J M A, Bekkers, J A, Kempers, M, Houweling, A C, Baars, M, Overwater, E, Hilhorst-Hofstee, Y, Barge-Schaapveld, D Q C M, Rompen, E, Krapels, I P C, Dulfer, E, Wessels, M W, Loeys, B L, Verhagen, H J M, Maugeri, A, Roos-Hesselink, J W, Brüggenwirth, H T & van de Laar, I M B H 2022, ' Expanding the genetic and phenotypic spectrum of ACTA2-related vasculopathies in a Dutch cohort ', Genetics in Medicine, vol. 24, no. 10, pp. 2112-2122 . https://doi.org/10.1016/j.gim.2022.07.009
Genetics in medicine, 24(10), 2112-2122. Lippincott Williams and Wilkins

Purpose: Heterozygous pathogenic/likely pathogenic (P/LP) variants in the ACTA2 gene confer a high risk for thoracic aortic aneurysms and aortic dissections. This retrospective multicenter study elucidates the clinical outcome of ACTA2-related vascul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2e29662a4a12709af79c372e156311d
https://pure.eur.nl/en/publications/f9755570-5ef0-41b5-bdb1-bd3ba057c2f1

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