Cardiovascular disease in Alpha 1 antitrypsin deficiency: an observational study assessing the role of neutrophil proteinase activity and the suitability of validated screening tools

Autor: E. Sapey, L. E. Crowley, R. G. Edgar, D. Griffiths, S. Samanta, H. Crisford, C. E. Bolton, J. R. Hurst, R. A. Stockley

Publikováno v: Orphanet Journal of Rare Diseases, Vol 19, Iss 1, Pp 1-11 (2024)

Abstract Background Alpha 1 Antitrypsin Deficiency (AATD) is a rare, inherited lung disease which shares features with Chronic Obstructive Pulmonary Disease (COPD) but has a greater burden of proteinase related tissue damage. These proteinases are as

Externí odkaz: https://doaj.org/article/5814b8a5090446efb43bb13c7ea46ffc

Exploring the Therapeutic Potential of Elastase Inhibition in Age-Related Macular Degeneration in Mouse and Human

Autor: Soumya Navneet, Carlene Brandon, Kit Simpson, Bärbel Rohrer

Publikováno v: Cells, Vol 12, Iss 9, p 1308 (2023)

Abnormal turnover of the extracellular matrix (ECM) protein elastin has been linked to AMD pathology. Elastin is a critical component of Bruch’s membrane (BrM), an ECM layer that separates the retinal pigment epithelium (RPE) from the underlying ch

Externí odkaz: https://doaj.org/article/c0ab253c49c04397a91d6890106b3163

Role of proteases and antiprotease in the etiology of chronic pancreatitis

Autor: Srimanjari Kavutharapu, Balakrishna Nagalla, Vidyasagar Abbagani, Shravan K Porika, Jyothy Akka, Pratibha Nallari, Venkateshwari Ananthapur

Publikováno v: The Saudi Journal of Gastroenterology, Vol 18, Iss 6, Pp 364-368 (2012)

Background/Aim: Chronic pancreatitis (CP) is the progressive and irreversible destruction of the pancreas characterized by the permanent loss of endocrine and exocrine function. Trypsin, the most important digestive enzyme plays a central role in the

Externí odkaz: https://doaj.org/article/c083fb3da5c44b6d99c435b828cfefc9

A preliminary study of inflammatory markers in non-alcoholic steatohepatitis patients

Autor: Dhastagir Sultan Sheriff, Manopriya T. Priya

Publikováno v: Libyan Journal of Medicine, Vol 5, Iss 0, Pp 1-4 (2010)
Libyan Journal of Medicine; Vol 5 (2010) incl Supplements
Libyan Journal of Medicine; Vol 5, No 1 (2010)
The Libyan Journal of Medicine

It was reported that C-reactive protein (CRP) levels increase in parallel with the progression of chronic liver diseases, such as chronic hepatitis and liver cirrhosis. Inflammatory markers, such as high sensitive C-reactive protein (hsCRP), ferritin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03f1b9354b3798274e2d11d145342909
https://doi.org/10.3402/ljm.v5i0.5071

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