Hormone receptor expression patterns define clinically meaningful subgroups of endometrioid ovarian carcinoma

Autor: Michael Churchman, Tzyvia Rye, Fiona Nussey, Melanie Mackean, Robert L Hollis, Charlie Gourley, Yasushi Iida, John P. Thomson, C. Simon Herrington, Barbara Stanley

Publikováno v: Gynecologic Oncology
Hollis, R, Stanley, B, Iida, Y, Thomson, J, Churchman, M, Rye, T, Mackean, M J, Nussey, F, Gourley, C & Herrington, C S 2019, ' Hormone receptor expression patterns define clinically meaningful subgroups of endometrioid ovarian carcinoma ', Gynecologic Oncology, vol. 155, no. 2, pp. 318-323 . https://doi.org/10.1016/j.ygyno.2019.09.001, https://doi.org/10.1016/j.ygyno.2019.09.001

Background Numerous studies have investigated the association between hormone receptor expression and clinical outcome in ovarian carcinoma (OC); however, these have largely focussed on serous OCs, with few studies reporting specifically on endometri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::200b8cdaa79e130432ff75817701585f
http://europepmc.org/articles/PMC6854467

The activation trajectory of plasmacytoid dendritic cells in vivo during a viral infection

Autor: Jean-Luc Davignon, Karima Naciri, Rabie Chelbi, Gilles Bessou, Chuang Dong, Nils Collinet, Michael Valente, Geoffray Brelurut, Pierre Milpied, Abdenour Abbas, Morgane Thomas-Chollier, Noudjoud Attaf, Thien-Phong Vu Manh, Inaki Cervera-Marzal, Alexandra-Chloé Villani, Benjamin Rauwel, Denis Thieffry, Marc Dalod, Elena Tomasello

Publikováno v: Nature Immunology
Nature Immunology, Nature Publishing Group, 2020, 21 (9), pp.983-997. ⟨10.1038/s41590-020-0731-4⟩
Nature Immunology, 2020, 21 (9), pp.983-997. ⟨10.1038/s41590-020-0731-4⟩
Nature immunology

International audience; Plasmacytoid dendritic cells (pDCs) are a major source of type I interferon (IFN-I). What other functions pDCs exert in vivo during viral infections is controversial, and more studies are needed to understand their orchestrati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd76519d3ec2c2f1de126656bc2665f9
https://hal.archives-ouvertes.fr/hal-02980944/file/2020_11_30_Abbas_et_al_2020_accepted_manuscript_for_HAL_small_size.pdf

MiR-18a and miR-18b are expressed in the stroma of oestrogen receptor alpha negative breast cancers

Autor: Deirdre Cronin-Fenton, Ivar Skaland, Miriam Ragle Aure, Kristine Kleivi Sahlberg, Kristin Jonsdottir, Nina Egeland, Einar Gudlaugsson, Emiel A. M. Janssen, Jan P. A. Baak, Vessela N. Kristensen

Publikováno v: BMC Cancer
BMC Cancer, Vol 20, Iss 1, Pp 1-14 (2020)
Egeland, N G, Jonsdottir, K, Aure, M R, Sahlberg, K, Kristensen, V N, Cronin-Fenton, D, Skaland, I, Gudlaugsson, E, Baak, J P A & Janssen, E A M 2020, ' MiR-18a and miR-18b are expressed in the stroma of oestrogen receptor alpha negative breast cancers ', BMC Cancer, vol. 20, no. 1, pp. 377 . https://doi.org/10.1186/s12885-020-06857-7
377 (2020)
Egeland, N G, Jonsdottir, K, Aure, M R, Sahlberg, K, Kristensen, V N, Cronin-Fenton, D, Skaland, I, Gudlaugsson, E, Baak, J P A & Janssen, E A M 2020, ' MiR-18a and miR-18b are expressed in the stroma of oestrogen receptor alpha negative breast cancers ', BMC Cancer, vol. 20, no. 1, 377 . https://doi.org/10.1186/s12885-020-06857-7

Background Previously, we have shown that miR-18a and miR-18b gene expression strongly correlates with high proliferation, oestrogen receptor -negativity (ER−), cytokeratin 5/6 positivity and basal-like features of breast cancer. Methods We investi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b0c414d25157537f7229e3d0aae913c
http://europepmc.org/articles/PMC7201801

Oestrogen receptor α AF-1 and AF-2 domains have cell population-specific functions in the mammary epithelium

Autor: Cagnet, Stéphanie, Ataca, Dalya, Sflomos, George, Aouad, Patrick, Schuepbach-Mallepell, Sonia, Hugues, Henry, Krust, Andrée, Ayyanan, Ayyakkannu, Scabia, Valentina, Brisken, Cathrin

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Nature communications, vol. 9, no. 1, pp. 4723
Nature Communications
Nature Communications, 2018, 9 (1), ⟨10.1038/s41467-018-07175-0⟩

Oestrogen receptor α (ERα) is a transcription factor with ligand-independent and ligand-dependent activation functions (AF)-1 and -2. Oestrogens control postnatal mammary gland development acting on a subset of mammary epithelial cells (MECs), term

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::37eac31573f29d80222640b3da063824
http://link.springer.com/article/10.1038/s41467-018-07175-0

The selective peroxisome proliferator-activated receptor alpha modulator (SPPARMα) paradigm: conceptual framework and therapeutic potential : A consensus statement from the International Atherosclerosis Society (IAS) and the Residual Risk Reduction Initiative (R3i) Foundation

Autor: Fruchart, J.C., Santos, R.D., Aguilar-Salinas, C., Aikawa, M., Al Rasadi, K., Amarenco, P., Barter, P.J., Ceska, R., Corsini, A., Després, J.P., Duriez, P., Eckel, R.H., Ezhov, M.V., Farnier, M., Ginsberg, H.N., Hermans, M.P., Ishibashi, S., Karpe, F., Kodama, T., Koenig, W., Krempf, M., Lim, S., Lorenzatti, A.J., McPherson, R., Nuñez-Cortes, J.M., Nordestgaard, B.G., Ogawa, H., Packard, C.J., Plutzky, J., Ponte-Negretti, C.I., Pradhan, A., Ray, K.K., Reiner, Ž., Ridker, P.M., Ruscica, M., Sadikot, S., Shimano, H., Sritara, P., Stock, J.K., Su, T.C., Susekov, A.V., Tartar, A., Taskinen, M.R., Tenenbaum, A., Tokgözoğlu, L.S., Tomlinson, B., Tybjærg-Hansen, A., Valensi, P., Vrablík, M., Wahli, W., Watts, G.F., Yamashita, S., Yokote, K., Zambon, A., Libby, P.

Publikováno v: Cardiovascular diabetology, vol. 18, no. 1, pp. 71

In the era of precision medicine, treatments that target specific modifiable characteristics of high-risk patients have the potential to lower further the residual risk of atherosclerotic cardiovascular events. Correction of atherogenic dyslipidemia,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1900::1e42e4b07a96300e14b1450540aec81b
https://serval.unil.ch/resource/serval:BIB_A62033B5071E.P001/REF.pdf